Induced Pluripotent Stem Cells News and Research

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Gene therapy and glycoside drugs offer new hope for polycystic kidney disease treatment

Researchers have shown that dangerous cysts, which form over time in polycystic kidney disease (PKD), can be prevented by a single normal copy of a defective gene.

4 Apr 2024

JAX researchers develop a powerful platform to study human health conditions

In humans, the exact same mutation in a specific gene can produce widely different outcomes. It's a bit like adding the same amount of salt to different recipes-;the effect on the finished dish can be quite different, depending on the mix of other ingredients.

3 Apr 2024

Household chemicals endanger brain's myelin-forming cells

Study uncovers how environmental chemicals, specifically organophosphate flame retardants and quaternary compounds, negatively affect oligodendrocyte development, implicating them in potential neurodevelopmental risks such as ADHD and autism, by employing an innovative high-throughput screening approach on mouse and human stem cell-derived models.

26 Mar 2024

Scientists transform skin cells into functional eggs in mice

New research from Oregon Health & Science University describes the science behind a promising technique to treat infertility by turning a skin cell into an egg that is capable of producing viable embryos.

9 Mar 2024

Breakthrough in CRISPR delivery promises safer gene editing

Recent research in PNAS highlights advancements in non-viral, cell-specific delivery methods for CRISPR-Cas systems, emphasizing their potential to enhance research and gene therapy applications by minimizing risks associated with off-target effects and improving targeted delivery.

7 Mar 2024

MGI Enters Strategic Partnership with Prepaire Labs to Advance Drug Discovery and Precision Medicine

MGI, a company committed to building core tools and technology to lead life science, today announced its collaboration with Prepaire Labs at MEDLAB Middle East 2024 to further empower precision medicine.

From MGI 6 Mar 2024

Scientists develop robust iPSC-derived rejuvenated T lymphocytes for cervical cancer treatment

Cervical cancer is among the most common malignancies affecting women worldwide. In 2020 alone, approximately 600,000 women were diagnosed with this disease, and over 314,000 died from it.

5 Mar 2024

New method simplifies production of limb progenitor cells from fibroblasts

In a collaborative study, researchers from Kyushu University and Harvard Medical School have identified proteins that can turn or "reprogram" fibroblasts -; the most commonly found cells in skin and connective tissue -; into cells with similar properties to limb progenitor cells.

4 Mar 2024

Neural cell culture model sheds light on the intricate mechanisms underlying neurodegeneration

Scientists at the University of Zurich have developed an innovative neural cell culture model, shedding light on the intricate mechanisms underlying neurodegeneration.

22 Feb 2024

Breaking through new research barriers with iPSC technology

In this interview, we speak to Keith Olson and Coby Carlson from Fujifilm Cellular Dynamics about their iPSC technology.

From FUJIFILM Cellular Dynamics 15 Feb 2024

Tiny device could help improve safety, effectiveness of cell therapy for spinal cord injury patients

A tiny device built by scientists at MIT and the Singapore-MIT Alliance for Research and Technology could be used to improve the safety and effectiveness of cell therapy treatments for patients suffering from spinal cord injuries.

7 Feb 2024

Scientists reprogram canine stem cells from urine

Dog owners may need to learn to appreciate their best friend's urine. Scientists at Osaka Metropolitan University have devised an efficient, non-invasive, and pain-free method to reprogram canine stem cells from urine samples, bringing furry companions one step closer to veterinary regenerative treatment.

21 Dec 2023

Embryonic immune sensor could key to creating patient-derived blood stem cells

A microbial sensor that helps identify and fight bacterial infections also plays a key role in the development of blood stem cells, valuable new insight in the effort to create patient-derived blood stem cells that could eliminate the need for bone marrow transplants.

19 Dec 2023

Patient-specific muscle models pave way for personalized neuromuscular therapies

Scientists have so far identified around 800 different neuromuscular diseases. These conditions are caused by problems in the way muscle cells, motor neurons and peripheral cells interact.

19 Dec 2023

UB research identifies key mechanism in infantile cystinosis

University at Buffalo research has identified how a misstep in the genesis of a key component of the kidney causes infantile cystinosis, a rare disease that significantly shortens the lifespan of patients.

11 Dec 2023

New heart organoid model could revolutionize drug development and toxicology studies

Heart disease kills 18 million people each year, but the development of new therapies faces a bottleneck: no physiological model of the entire human heart exists – so far.

28 Nov 2023

Genetic mutation in OXR1 gene linked to brain development issues

Study investigates the effects of a loss-of-function mutation in the OXR1 gene on neurodevelopment and cellular functions in the human brain. The research shows that OXR1 deficiency impairs neural differentiation, increases sensitivity to oxidative stress, and alters histone methylation, impacting brain development and potentially contributing to neurological disorders.

27 Nov 2023