Induced Pluripotent Stem Cells News and Research

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UAB first in U.S. with cell-processing workstation

The University of Alabama at Birmingham has taken a significant step toward making sophisticated cell therapy a part of patient care with its acquisition of the first cell-processing workstation (CPWS) from SANYO North America Corporation (SANYO) in the United States.

8 Jun 2011

Scientists add four proteins to skin cells to create functional neurons

The New York Stem Cell Foundation - a non-profit organization dedicated to advancing cures for major diseases through stem cell research - today applauded the announcement by Stanford University scientists, led by NYSCF - Robertson Investigator Dr. Marius Wernig, that they directly converted skin cells of humans into functional neurons.

27 May 2011

Stem cell pluripotency depends on E-cadherin molecule

Researchers of the Max Delbr-ck Center for Molecular Medicine (MDC) Berlin-Buch have discovered what enables embryonic stem cells to differentiate into diverse cell types and thus to be pluripotent. This pluripotency depends on a specific molecule - E-cadherin - hitherto primarily known for its role in mediating cell-cell adhesion as a kind of "intracellular glue".

27 May 2011

Researchers convert human skin cells directly into functional neurons within four to five weeks

Human skin cells can be converted directly into functional neurons in a period of four to five weeks with the addition of just four proteins, according to a study by researchers at the Stanford University School of Medicine.

27 May 2011

Scientists mimic dyskeratosis congenita through study of undifferentiated iPS cells

A rare genetic disease called dyskeratosis congenita, caused by the rapid shortening of telomeres, can be mimicked through the study of undifferentiated induced pluripotent stem cells, according to new findings from the Stanford University School of Medicine.

24 May 2011

Salk researchers successfully edit diseased gene in patient-specific induced pluripotent stem cells

In principle, genetic engineering is simple, but in practice, replacing a faulty gene with a healthy copy is anything but. Using mutated versions of the lamin A gene as an example to demonstrate the versatility of their virus-based approach, researchers at the Salk Institute for Biological Studies successfully edited a diseased gene in patient-specific induced pluripotent stem cells as well as adult stem cells.

21 May 2011

GIS discovery could help generate stem cells more efficiently for biomedical applications

A team of scientists from Genome Institute of Singapore (GIS) of the Agency for Science, Technology and Research (A*STAR) have shown how proteins involved in controlling genes work together to carry out their functions in stem cells and demonstrated for the very first time, how they can change interaction partners to make other types of cells.

20 May 2011

iPSC-derived liver cells hold potential as alternative to liver transplants

Johns Hopkins researchers have demonstrated that human liver cells derived from adult cells coaxed into an embryonic state can engraft and begin regenerating liver tissue in mice with chronic liver damage.

12 May 2011

Scripps Research receives CIRM grant for new research in stem cell biology and disease origins

Stem cells have huge potential in medicine because they have the ability to change or differentiate into many different cell types potentially providing a source of cells to replace those that have been permanently lost by a patient.

6 May 2011

Researchers develop new gene therapy technique for CGD treatment

Researchers have developed an effective technique that uses gene therapy on stem cells to correct chronic granulomatous disease in cell culture, which could eventually serve as a treatment for this rare, inherited immune disorder, according to a study published in Blood, the Journal of the American Society of Hematology.

29 Apr 2011

AAN, PDF honor Boston researcher with Clinician Scientist Development Award

A clinician scientist at Massachusetts General Hospital in Boston is receiving $240,000 to further his research into how stem cells may be used to treat Parkinson's disease through the American Academy of Neurology Foundation and the Parkinson's Disease Foundation Clinician Scientist Development Award in Parkinson's Disease Research.

15 Apr 2011

Pig stem cell transplants key to future research into retina treatment

A team of American and Chinese scientists studying the role of stem cells in repairing damaged retina tissue have found that pigs represent an effective proxy species to research treatments for humans. The study, published in STEM CELLS, demonstrates how cells can be isolated and transplanted between pigs, overcoming a key barrier to the research.

13 Apr 2011

New nonviral method to create cardiac cells

Johns Hopkins scientists have developed a simplified, cheaper, all-purpose method they say can be used by scientists around the globe to more safely turn blood cells into heart cells. The method is virus-free and produces heart cells that beat with nearly 100 percent efficiency, they claim.

11 Apr 2011

Diseased human hepatocytes successfully reprogrammed into induced pluripotent stem cells

Study shows, for the first time, the successful reprogramming of diseased human hepatocytes into induced pluripotent stem cells (iPSC).

1 Apr 2011

Researchers create hiPS-RPE cells to treat age-related macular degeneration

The notion of transplanting adult stem cells to treat or even cure age-related macular degeneration has taken a significant step toward becoming a reality. In a study published today in Stem Cells, Georgetown University Medical Center researchers have demonstrated, for the first time, the ability to create retinal cells derived from human-induced pluripotent stem cells that mimic the eye cells that die and cause loss of sight.

24 Mar 2011

CDI announces publication of footprint-free iPSCs production method in PLoS ONE journal

Cellular Dynamics International, the world's largest producer of human tissue cells for drug discovery and safety testing, today announced the publication of research demonstrating an efficient and scalable method of creating DNA integration-free, or footprint-free, induced pluripotent stem cells under a feeder-free condition using chemically defined media.

5 Mar 2011

Researchers transform human embryonic stem cell into neuron that dies early in Alzheimer's disease

Northwestern Medicine researchers for the first time have transformed a human embryonic stem cell into a critical type of neuron that dies early in Alzheimer's disease and is a major cause of memory loss.

4 Mar 2011

Scientists find reprogramming-associated mutations in hiPSCs

Ordinary human cells reprogrammed as induced pluripotent stem cells may ultimately revolutionize personalized medicine by creating new and diverse therapies unique to individual patients.

3 Mar 2011

Rare heart defect reproduced in petri dish, hope for cure

U.S. researchers have created beating heart cells in the lab with the same heart defect using skin cells taken from children with a rare heart defect. This means they can now test new drugs in human cells instead of mice.

13 Feb 2011

First 7 stem cell lines grown at UMMS Human Stem Cell Bank ready for global distribution

The first seven stem cell lines grown and banked at the University of Massachusetts Medical School's Human Stem Cell Bank are ready for worldwide distribution to researchers working on discovering new therapeutic treatments for diseases such as cancer, juvenile diabetes, Alzheimer's and Parkinson's, among others.

11 Feb 2011

Induced Pluripotent Stem Cells News and Research

UAB first in U.S. with cell-processing workstation

Scientists add four proteins to skin cells to create functional neurons

Stem cell pluripotency depends on E-cadherin molecule

Researchers convert human skin cells directly into functional neurons within four to five weeks

Scientists mimic dyskeratosis congenita through study of undifferentiated iPS cells

Salk researchers successfully edit diseased gene in patient-specific induced pluripotent stem cells

GIS discovery could help generate stem cells more efficiently for biomedical applications

iPSC-derived liver cells hold potential as alternative to liver transplants

Scripps Research receives CIRM grant for new research in stem cell biology and disease origins

Researchers develop new gene therapy technique for CGD treatment

AAN, PDF honor Boston researcher with Clinician Scientist Development Award

Pig stem cell transplants key to future research into retina treatment

New nonviral method to create cardiac cells

Diseased human hepatocytes successfully reprogrammed into induced pluripotent stem cells

Researchers create hiPS-RPE cells to treat age-related macular degeneration

CDI announces publication of footprint-free iPSCs production method in PLoS ONE journal

Researchers transform human embryonic stem cell into neuron that dies early in Alzheimer's disease

Scientists find reprogramming-associated mutations in hiPSCs

Rare heart defect reproduced in petri dish, hope for cure

First 7 stem cell lines grown at UMMS Human Stem Cell Bank ready for global distribution

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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