Inflammasome News and Research

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Colchicine does not reduce perioperative AF or MINS in major non-cardiac thoracic surgery

Colchicine does not significantly reduce perioperative atrial fibrillation (AF) or myocardial injury after non-cardiac surgery (MINS) in patients undergoing major non-cardiac thoracic surgery, according to late breaking research presented in a Hot Line session today at ESC Congress 2023.

25 Aug 2023

Ketogenic diets, gut microbiota, and health effects

The evidence on ketogenic diets (KDs) from the past three decades.

24 Aug 2023

Small molecule inhibitor of the NLRP3 inflammasome for treating autoinflammatory diseases

Researchers described the preclinical profile of JT002, a novel and orally bioavailable small molecule inhibitor of the NLRP3 inflammasome.

24 Aug 2023

Study shows link between regulatory T cells and anxiety, depression, Alzheimer's disease

Regulatory T cells-;work horses of the body's immune system-;may also stabilize mood, according to a study. Forkhead box P3 (Foxp3) is a transcription factor that controls the production of regulatory T cells (Tregs).

22 Aug 2023

Research illustrates the role of Gasdermin D protein in immunity tolerance to food

A research team led by Prof. ZHU Shu from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) illustrated the role of Gasdermin D (GSDMD) protein in immunity tolerance to food in the small intestine.

11 Aug 2023

NLRP3 inflammasome plays a role in podocyte aging

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, entitled, "Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span."

8 Aug 2023

Surprising new role for a key immune regulator revealed

A signaling protein known as STING is a critical player in the human immune system, detecting signs of danger within cells and then activating a variety of defense mechanisms.

3 Aug 2023

The roles and plausible mechanisms of pyroptosis in renal inflammation and fibrosis

Researchers summarize available data on pyroptosis in the context of renal fibrosis, as well as its prevention and treatment.

1 Aug 2023

Researchers discover a protein that plays critical roles in alerting the body to a bacterial infection

A team led by researchers at Massachusetts General Hospital (MGH) has discovered a protein that plays critical roles in alerting the body to a bacterial infection and initiating an effective immune response to fight back against the invasion.

27 Jul 2023

Researchers identify several steps in a cellular process responsible for triggering inflammatory responses

Cedars-Sinai investigators have identified several steps in a cellular process responsible for triggering one of the body's important inflammatory responses.

16 Jun 2023

Biologists discover a previously unknown way that the immune system detects viruses

Inflammasomes make up an intricate system of molecular sensors that our bodies use to sound an alarm when an infection occurs.

8 Jun 2023

St. Jude researchers discover NLRP12 as a direct bridge from hemolysis to inflammatory disease

Infections and other diseases can cause red blood cells to rupture, releasing the oxygen-binding molecule hemoglobin, which breaks down into heme.

1 Jun 2023

Study findings offer hope for the development of novel treatments for leishmaniasis

In an article published in the journal Nature Communications, researchers at the University of São Paulo (USP) in Brazil show how protozoans of the genus Leishmania that cause leishmaniasis manipulate a protein that plays an essential role in the organism's defense in order to continue to replicate, preventing the body from vanquishing the disease.

23 May 2023

Ketogenic diet: A metabolic makeover boosting immunity and battling inflammation

A recent study discusses alterations in the human metabolic fingerprint associated with the keto diet.

8 May 2023

How do viral infections cause autoimmune diseases?

Researchers describe the pathological mechanisms of virus-induced autoimmune diseases.

28 Mar 2023

Candida auris escapes innate immunity through metabolic reprogramming

A team of scientists from Australia and Israel demonstrates that Candida auris, a fungus associated with life-threatening and drug-resistant infections, escapes the host's innate immune response by destroying macrophages through metabolic reprogramming. The fungus is also capable of escaping antimicrobial inflammatory response.

23 Mar 2023

Inflammasome News and Research

Colchicine does not reduce perioperative AF or MINS in major non-cardiac thoracic surgery

Ketogenic diets, gut microbiota, and health effects

Small molecule inhibitor of the NLRP3 inflammasome for treating autoinflammatory diseases

Study shows link between regulatory T cells and anxiety, depression, Alzheimer's disease

Research illustrates the role of Gasdermin D protein in immunity tolerance to food

NLRP3 inflammasome plays a role in podocyte aging

Surprising new role for a key immune regulator revealed

The roles and plausible mechanisms of pyroptosis in renal inflammation and fibrosis

Researchers discover a protein that plays critical roles in alerting the body to a bacterial infection

Researchers identify several steps in a cellular process responsible for triggering inflammatory responses

Biologists discover a previously unknown way that the immune system detects viruses

St. Jude researchers discover NLRP12 as a direct bridge from hemolysis to inflammatory disease

Study findings offer hope for the development of novel treatments for leishmaniasis

Ketogenic diet: A metabolic makeover boosting immunity and battling inflammation

How do viral infections cause autoimmune diseases?

Candida auris escapes innate immunity through metabolic reprogramming

Study reveals the underlying mechanism by which TKI cancer drugs cause inflammation

The relationship between intestinal microbiome dysbiosis and atherosclerosis

Nasal administration of a fully human anti-CD3 monoclonal antibody modulates T cell inflammatory responses in COVID-19

Mass spectrometry-based identification of COVID-19 biomarkers

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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