Inflammation News and Research

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EMA grants Advanced Therapy Medicinal Product classification for TxCell's Col-Treg

TxCell SA, a biotechnology company developing innovative, personalized cell-based immunotherapies using antigen specific regulatory T-cells (Ag-Tregs) for severe chronic inflammatory and autoimmune diseases, announces today that Col-Treg, its second therapeutic candidate from its ASTrIA platform, has been granted Advanced Therapy Medicinal Product (ATMP) classification by the Committee for Advanced Therapies (CAT) of the European Medicines Agency.

22 May 2014

Effects of radiofrequency ablation and complete endoscopic resection are equal in dysplastic Barrett's esophagus

According to a new systematic review article, radiofrequency ablation and complete endoscopic resection are equally effective in the short-term treatment of dysplastic Barrett's esophagus, but adverse event rates are higher with complete endoscopic resection.

22 May 2014

Scientists discover link between circadian clock disturbances and inflammatory diseases

A disruption of circadian rhythms, when combined with a high-fat, high-sugar diet, may contribute to inflammatory bowel disease and other harmful conditions, according to a recent study conducted by researchers at Rush University Medical Center.

22 May 2014

AbbVie receives HUMIRA orphan drug designation from FDA for treatment of non-infectious uveitis

AbbVie announced today that the U.S. Food and Drug Administration has granted HUMIRA orphan drug designation for the treatment of non-infectious intermediate, posterior, or pan-uveitis, or chronic non-infectious anterior uveitis, a group of rare but serious inflammatory diseases of the eye.

21 May 2014

New compound restores learning, memory and other symptoms of AD in mice

A molecular compound developed by Saint Louis University scientists restored learning, memory and appropriate behavior in a mouse model of Alzheimer's disease, according to findings in the May issue of the Journal of Alzheimer's Disease.

21 May 2014

Vitamin E-rich oils may increase incidence of asthma, says study

A large new Northwestern Medicine- study upends our understanding of vitamin E and ties the increasing consumption of supposedly healthy vitamin E-rich oils -- canola, soybean and corn - to the rising incidence of lung inflammation and, possibly, asthma.

21 May 2014

Physical activity may be able to prevent overweight women from developing heart disease

For otherwise healthy middle-aged women who are overweight or obese, physical activity may be their best option for avoiding heart disease, according to a study that followed nearly 900 women for seven years.

21 May 2014

Study: Hearing impairment linked with sleep apnea

Both high and low frequency hearing impairment have been linked with sleep apnea in a new study of nearly 14,000 individuals.

21 May 2014

Isis Pharmaceuticals starts Phase 1 clinical study of ISIS-PKKRx to treat patients with HAE

Isis Pharmaceuticals, Inc. (NASDAQ: ISIS) announced today that it initiated a Phase 1 clinical study of ISIS-PKKRx. ISIS-PKKRx is an antisense drug in development to treat patients with hereditary angioedemia (HAE).

21 May 2014

New drug offers promising possibility for treating adults with periodontitis

Nearly half of all adults in the United States suffer from the gum disease periodontitis, and 8.5 percent have a severe form that can raise the risk of heart disease, diabetes, arthritis and pregnancy complications.

21 May 2014

New antibody can improve quality of life for individuals with asthma

Researchers at St. Joseph's Healthcare Hamilton and McMaster University have successfully tested an antibody that can improve the quality of life for individuals with asthma by relieving inflammation in the lungs.

21 May 2014

FDA approves Takeda's Entyvio for severe active ulcerative colitis and Crohn's disease

Takeda Pharmaceutical Company Limited and its wholly-owned subsidiary, Takeda Pharmaceuticals U.S.A., Inc., has announced that the United States (U.S.) Food and Drug Administration (FDA) simultaneously approved a new biologic therapy, Entyvio™ (vedolizumab), for the treatment of adults with moderately to severely active ulcerative colitis (UC) and Crohn's disease (CD).

21 May 2014

Cigarette smoking and male sex are independent risk factors for ocular sarcoidosis

Cigarette smoking and male sex are significant risk factors for developing ocular sarcoidosis, according to a new study presented at the 2014 American Thoracic Society International Conference.

21 May 2014

Sanofi presents Phase II trial results for investigational vaccine for prevention of CDI

Sanofi Pasteur, the vaccines division of Sanofi, presented Phase II (H-030-012) trial results for an investigational vaccine for the prevention of Clostridium difficile infection at the 114th General Meeting of the American Society for Microbiology.

20 May 2014

New technique can predict which stroke victims will benefit from clot-busting drugs

Johns Hopkins researchers say they have developed a technique that can predict — with 95 percent accuracy — which stroke victims will benefit from intravenous, clot-busting drugs and which will suffer dangerous and potentially lethal bleeding in the brain.

20 May 2014

Shire intends to submit NDA for lifitegrast to treat dry eye disease

Following a May 15, 2014, meeting with the U.S. Food and Drug Administration (FDA), Shire plc, the global specialty biopharmaceutical company, announces today that it intends to submit a New Drug Application for lifitegrast as a treatment for the signs and symptoms of dry eye disease in adults in the first-quarter 2015, as we complete remaining chemistry and manufacturing work.

19 May 2014

Bacteria that cause gum disease also promote heart disease, shows study

A University of Florida study shows that the same bacteria that cause gum disease also promotes heart disease - a discovery that could change the way heart disease is diagnosed and treated. Researchers report their findings today at the annual meeting of the American Society for Microbiology.

19 May 2014

Study shows commonly used statin drug does not reduce acute COPD exacerbations

A statin drug commonly used to lower cholesterol is not effective in reducing the number and severity of flare ups from chronic obstructive pulmonary disease (COPD), according to the results of a large multicenter clinical trial designed and directed by Gerard J. Criner, MD, Director of Pulmonary and Critical Care Medicine at Temple University Hospital in Philadelphia, PA.

19 May 2014

Painkillers may prevent repeated urinary tract infections in women, says study

Women plagued by repeated urinary tract infections may be able to prevent the infections with help from over-the-counter painkillers, new research in mice shows.

19 May 2014

Chronic bystander viral impairs development of memory T cells

Studies of vaccine programs in the developing world have revealed that individuals with chronic infections such as malaria and hepatitis tend to be less likely to develop the fullest possible immunity benefits from vaccines for unrelated illnesses.

16 May 2014

Inflammation News and Research

EMA grants Advanced Therapy Medicinal Product classification for TxCell's Col-Treg

Effects of radiofrequency ablation and complete endoscopic resection are equal in dysplastic Barrett's esophagus

Scientists discover link between circadian clock disturbances and inflammatory diseases

AbbVie receives HUMIRA orphan drug designation from FDA for treatment of non-infectious uveitis

New compound restores learning, memory and other symptoms of AD in mice

Vitamin E-rich oils may increase incidence of asthma, says study

Physical activity may be able to prevent overweight women from developing heart disease

Study: Hearing impairment linked with sleep apnea

Isis Pharmaceuticals starts Phase 1 clinical study of ISIS-PKKRx to treat patients with HAE

New drug offers promising possibility for treating adults with periodontitis

New antibody can improve quality of life for individuals with asthma

FDA approves Takeda's Entyvio for severe active ulcerative colitis and Crohn's disease

Cigarette smoking and male sex are independent risk factors for ocular sarcoidosis

Sanofi presents Phase II trial results for investigational vaccine for prevention of CDI

New technique can predict which stroke victims will benefit from clot-busting drugs

Shire intends to submit NDA for lifitegrast to treat dry eye disease

Bacteria that cause gum disease also promote heart disease, shows study

Study shows commonly used statin drug does not reduce acute COPD exacerbations

Painkillers may prevent repeated urinary tract infections in women, says study

Chronic bystander viral impairs development of memory T cells

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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