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Aggressive cancer treated successfully in mice

White blood cells from a strain of cancer-resistant mice cured advanced cancers in ordinary laboratory mice, researchers at Wake Forest University School of Medicine reported.

9 May 2006

New approach to treating breast cancer uses existing chemo drug

British scientists say women who develop breast cancer because of two common genetic mutations could have their treatment transformed by a chemotherapy drug which already exists.

1 May 2006

Genetic data from an island population proves to be a useful tool in understanding disease

With fewer than 4,000 residents, the genetically isolated Micronesian island of Kosrae, in the West Pacific, provides an ideal population in which to research heritability of disease.

20 Apr 2006

Promising treatment for Huntington's disease soon to be tested clinically

At the Institut Curie, CNRS and Inserm researchers have shown that cysteamine, which is already used to treat a rare disease called cystinosis, prevents the death of neurons in Huntington's disease. Like Alzheimer's and Parkinson's, Huntington's disease, is characterized by the abnormal death of neurons.

19 Apr 2006

Discovery of common genetic variation in an immune system gene that makes people much more likely to develop psoriasis

University of Michigan scientists have found a common genetic variation in an immune system gene that makes people much more likely to develop psoriasis - a disfiguring inflammatory skin disease.

19 Mar 2006

Link between genetic variation and outcome of antidepressant treatment

Whether depressed patients will respond to an antidepressant depends, in part, on which version of a gene they inherit, a study led by scientists at the National Institutes of Health (NIH) has discovered.

15 Mar 2006

Global evolutionary map reveals new insights into our last common ancestor

In 1870 the German scientist Ernst Haeckel mapped the evolutionary relationships of plants and animals in the first 'tree of life'.

7 Mar 2006

BRCA1 gene inhibits estrogen and progesterone

It's been known that the breast cancer susceptibility gene BRCA1 regulates use of estrogen in breast and other cells, but now researchers at Georgetown University Medical Center have discovered that it also controls activity of a second sex steroid hormone, progesterone.

27 Jan 2006

Genetic risk factor for West Nile virus infection identified

People who lack a cell surface protein called CCR5 are highly resistant to infection by HIV but may be at increased risk of developing West Nile virus (WNV) illness when exposed to the mosquito-borne virus, report researchers from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).

18 Jan 2006

Researchers discover how a gene linked to Parkinson’s disease can keep brain cells alive

Researchers at the University of Colorado at Denver and Health Sciences Center’s School of Medicine have uncovered how a gene linked to Parkinson’s disease can keep brain cells alive. The results suggest the possibility for new drugs that might regulate the gene and protect Parkinson’s patients from further cell damage.

29 Dec 2005

Common gene variation lessens Tamoxifen’s benefit

Researchers have discovered that one of the most commonly prescribed drugs for breast cancer, tamoxifen, may not be as effective for women who inherit a common genetic variation.

19 Dec 2005

Bacterial DNA and IVF contamination risk on New Scientist

Some children conceived by a common method of IVF could be carrying chunks of bacterial DNA in their chromosomes, according to a study in mice. The researchers who conducted the work say that such accidental genetic modification would be very rare, but they argue that fertility doctors should take more precautions to exclude it.

30 Nov 2005

Prion protein codon 129 genotype prevalence is altered in primary progressive aphasia

Most people with a rare type of dementia called primary progressive aphasia (PPA) have a specific combination of prion gene variants, a new study shows.

28 Nov 2005

Why some people do not respond as well as others to statin therapy

A newly discovered genetic variation, in combination with a second variation, reduces the ability of statin drugs to lower "bad" LDL cholesterol, researchers report at the American Heart Association's Scientific Sessions 2005.

20 Nov 2005

HapMap will give clues to many common diseases

Researchers say that they have completed a map that charts patterns of human genetic variation in the world population, to better understand human biology, evolution and how to diagnose diseases.

27 Oct 2005

Scientists have identified the gene which explains why eggs fail to produce a zygote

Scientists have identified the gene responsible for controlling a first key step in the creation of new life, according to new research published in the journal Nature.

27 Oct 2005

Mechanisms of evolution may be associated with disease

By comparing the human genome with that of the chimpanzee, man's closest living relative, researchers have discovered that chunks of similar DNA that have been flipped in orientation and reinserted into chromosomes are hundreds of times more common in primates than previously thought.

26 Oct 2005

Teens with missing part of a chromosome confirm genetic role in schizophrenia

A study in youth who are missing part of a chromosome is further implicating a suspect gene in schizophrenia.

23 Oct 2005

Dopamine link to psychiatric and neurological disorders

A gene that regulates dopamine levels in the brain is involved in the development of schizophrenia in children at high risk for the disorder, say researchers at the Stanford University School of Medicine, Lucile Packard Children's Hospital and the University of Geneva.

23 Oct 2005

New tool that may prove to be invaluable for investigating the long-term mutagenic effects of chemotherapy and radiation

Scientists have developed a new tool that may prove to be invaluable for investigating the long-term mutagenic effects of chemotherapy and radiation, therapies that are widely used for the treatment of cancer.

17 Oct 2005