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$5 million in federal funding to accelerate potential treatments for urea cycle disorders

An international research consortium co-led by Andrea L. Gropman, M.D., at Children's National Hospital has received $5 million in federal funding as part of an overall effort to better understand rare diseases and accelerate potential treatments to patients.

24 Oct 2019

Combination of two drugs disrupts cancer cells' ability to survive DNA damage, study finds

In continuing efforts to find novel ways to kill cancer cells, researchers at the University of Maryland School of Medicine have identified a new pathway that leads to the destruction of cancer cells.

14 Oct 2019

New genomics technique can be used to track down the causes of rare genetic diseases

A team led by a scientist at Scripps Research has invented a new genomics technique for tracking down the causes of rare genetic diseases.

11 Oct 2019

Researchers develop customized drug treatment to bypass patient’s unique mutation

An unprecedented case at Boston Children's Hospital shows that it's possible to do something that's never been done before: identify a patient's unique mutation, design a customized drug to bypass it, manufacture and test the drug, and obtain permission from the Food and Drug Administration (FDA) to begin treating the patient -- all in less than one year.

11 Oct 2019

Endometriosis: Thousands of women suffer from debilitating pain

Endometriosis affects approximately 1 in 10 women in their reproductive years. The condition, described as debilitating, painful, and emotionally-draining, has taken a toll on the lives of many women across the globe. But the condition isn’t getting the needed adequate attention, hinting the need for more research on ways to battle it.

8 Oct 2019

Study on gene mutations may lead to better diagnosis and treatment for cancer

When a cell divides into two daughter cells, it must replicate its DNA according to a very specific scenario. In the presence of some disruptive elements, however, cancer cells are unable to perform this operation optimally; replication then takes place more slowly and less efficiently.

25 Sep 2019

Genetic testing may help patients with metastatic breast cancer

Breast cancer is a condition wherein the cells in the breast grow uncontrollably. Breast cancer can spread to the other parts of the body, termed as metastatic breast cancer. It is one of the most aggressive and potentially deadly types of cancer.

10 Sep 2019

Women who inherit BRCA mutations have high risk of developing cancer

Women who inherit harmful mutations in the BRCA1 or BRCA2 gene are at high risk of developing breast and ovarian cancer.

24 Jul 2019

Fungal infection study identifies specific genetic vulnerability among Hmong people

Ten years ago, in Marathon County, Wisconsin, 55 people were sickened by an uncommon fungal infection called blastomycosis. Thirty patients were hospitalized. Two people died.

16 Jul 2019

Ancient epigenetic change deactivates some genes linked to cancer

An epigenetic change, a form of DNA control, that deactivates some genes linked to cancer late in human development has been conserved for more than 400 million years, new research led by the Garvan Institute of Medical Research suggests.

11 Jul 2019

Healthy mice pups can be produced from sperm without short RNA chains

Scientists from the University of Bath are challenging the claims of two high profile papers from 2018 which reported that in the mouse, RNA has to be added to sperm for them to be fully fertile.

4 Jul 2019

Learned avoidance behavior can be inherited for multiple generations, say Princeton researchers

Princeton University researchers have discovered that learned behaviors can be inherited for multiple generations in C. elegans, transmitted from parent to progeny via eggs and sperm cells.

7 Jun 2019

Study underpins new model of care for people diagnosed with bladder cancer

Bladder cancer is a painful and sometimes life-threatening condition that patients can find difficult to talk about, with many becoming homebound as they cope with debilitating side effects such as incontinence.

30 May 2019

Zebrafish embryo could help better understand the potential underpinnings of brain disorders

A close look at the rapidly developing zebrafish embryo is helping neuroscientists better understand the potential underpinnings of brain disorders, including autism and schizophrenia.

24 May 2019

Broccoli contains an ingredient that could target the "Achilles’ heel" of cancers

A new study from the Beth Israel Deaconess Medical Center has come up with a new study that reveals that broccoli, Brussels sprouts, kale, cauliflower, cabbage and collard greens contain a substance that could inactivate a vital gene that plays a role in cancers.

19 May 2019

Nanotubes enable movement of toxic protein linked to Huntington's disease

A toxic protein linked to Huntington's disease can move from neuron to neuron through a nanotube tunnel whose construction is initiated by a protein called Rhes, say scientists at Scripps Research.

11 May 2019

Researchers identify 34 genes associated with increased risk of ovarian cancer

A team of researchers at UCLA's Jonsson Comprehensive Cancer, Cedars-Sinai Cancer and Dana-Farber Cancer Institute have newly identified 34 genes that are associated with an increased risk for developing the earliest stages of ovarian cancer.

1 May 2019

TET proteins help regulate gene activity vital for normal antibody production

A family of cancer suppressive proteins, known as TET proteins, help regulate gene activity via their influence on chromosomal architecture. However, until now it wasn't entirely clear how genes were activated by TET proteins to make sure that cells perform their normal functions efficiently.

27 Apr 2019

Researchers investigate causal relationship between higher BMI and psoriasis

Studies have linked psoriasis and higher weight, but the causal relationship between the two has been unclear. What triggers what?

26 Apr 2019

New review highlights how lifestyle affects our genes

In the past decade, knowledge of how lifestyle affects our genes, a research field called epigenetics, has grown exponentially.

24 Apr 2019