Insulin News and Research

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Insulin is a hormone that is needed to convert glucose, starches and other food into energy needed for daily life. Insulin allows cells to use glucose for fuel and is secreted by beta cells in the islets of Langerhans. The release of insulin from the pancreas is stimulated by increased blood glucose, vagal nerve stimulation, and other factors. Insulin is obtained from various animals and available in a variety of preparations. Commercial insulin preparations differ in a number of ways, including differences in the animal species from which they are obtained; their purity, concentration, and solubility; and the time of onset and duration of their biologic action. An oral hypoglycemic agent is not a form of insulin therapy.

OSI Pharmaceuticals initiates two clinical trials with OSI-906 oral insulin-like growth factor-1 receptor inhibitor

OSI Pharmaceuticals, Inc. (NASDAQ: OSIP) announced today the initiation of two clinical trials with OSI-906, the Company’s potential first-in-class, oral insulin-like growth factor-1 receptor (IGF-1R) inhibitor. The first study is a Phase III, multi-center study that will evaluate the use of OSI-906 for patients with locally advanced or metastatic adrenocortical carcinoma (ACC).

4 Sep 2009

Reliable and relevant information needed to rein in the costs of federal health-care programs, says study

For economists and policy-makers to understand the true value of the costs and savings of preventive health programs for chronic disease, the Congressional Budget Office (CBO) should incorporate long-term clinical outcomes data and look beyond the 10-year window when making cost estimates, says a team of University of Chicago researchers in today's issue of Health Affairs.

3 Sep 2009

Medtronic's COPE-HCV clinical study commences

Medtronic, Inc., today reported the initiation and first enrollments of patients in COPE-HCV (COntinuous Interferon Delivery via the Medtronic Paradigm Pump Infusion System Clinical Evaluation for Chronic HCV), the company’s first-ever clinical study using an external pump infusion system to treat patients with the hepatitis C virus (HCV).

3 Sep 2009

Validity of Unigene’s patent on Fortical confirmed by the court

Unigene Laboratories, Inc. has reported that the U.S. District Court, Southern District of New York, has confirmed the validity of Unigene’s patent on Fortical and issued an order permanently enjoining Apotex Inc. and Apotex Corp. from further infringement of the patent.

3 Sep 2009

Strelitz Diabetes Center awarded a two-year grant for 12-LO research

Scientists at Eastern Virginia Medical School's Strelitz Diabetes Center have been awarded a two-year grant totaling $472,683 by the Juvenile Diabetes Research Foundation (JDRF).

3 Sep 2009

New device for treating hypoglycemia launched globally

At this year’s annual meeting of the International Society for Pediatric and Adolescent Diabetes (ISPAD) in Ljubljana, Slovenia, Medtronic, Inc. announced the global launch of a novel technology designed to provide additional protection against the risks associated with hypoglycemia.

3 Sep 2009

Alloantigen-specific Treg cells targeted for organ transplantation

An increased understanding of the role of the body's immune system in the development of diseases such as prostate cancer, squamous cell carcinoma (a type of skin cancer), type 1 diabetes, autoimmune liver disease, and in the rejection of transplanted organs by some transplant patients, has paved the way for a pioneering research programme which aims to develop 'enhanced' cells as therapies.

3 Sep 2009

Novo Nordisk's NCDP provides support for accurate cost and benefit assessments of preventive health

The National Changing Diabetes((R) )Program (NCDP), a program of Novo Nordisk, commends Representative Donna M. Christensen, M.D. (D-VI) and Michael C. Burgess, M.D. (R-TX) for sponsoring legislation that will lead to a more accurate assessment of the cost and benefits of preventive health, including preventing complications and delaying progression of chronic diseases such as diabetes.

From Novo Nordisk 2 Sep 2009

Researchers discover why smoking increases the risk of heart disease and stroke

Researchers have discovered a reason why smoking greatly increases the risk of heart disease and stroke. Nicotine promotes insulin resistance, also called prediabetes, which is a risk factor for cardiovascular disease, according to the new study, which was presented at The Endocrine Society's 91st Annual Meeting in Washington, D.C.

2 Sep 2009

Walking and biking raise health and fitness levels

Trying to get fit but can't work it into your daily schedule? Incorporating even relatively short bouts of exercise into a daily commute appears to deliver significant rewards, according to a new study from the University of North Carolina at Chapel Hill.

2 Sep 2009

Genes that regulate the energy consumption of cells have a different structure and expression in diabetics

Genes that regulate the energy consumption of cells have a different structure and expression in type II diabetics than they do in healthy people, according to a new study from the Swedish medical university Karolinska Institutet published in Cell Metabolism.

2 Sep 2009

Research reveals that dramatic maternal weight loss prevents obesity in their children

Adolescent and young children of obese mothers who underwent weight-loss surgery prior to pregnancy have been found to have a lower prevalence of obesity and significantly improved cardio-metabolic markers when compared to siblings born before the same obese mothers had weight-loss surgery. This new study has been accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

2 Sep 2009

Grant awarded to two researchers to study the role of GLP-1 in people at risk for or with diabetes

The American Diabetes Association Research Foundation has selected two scientists, University of Virginia Health System researcher Zhenqi Liu, MD, and Stanford University School of Medicine researcher Gerald Reaven, MD, to receive the American Diabetes Association-Novo Nordisk Clinical/Translational Research Award. This $1.2 million grant program supports efforts to study the effects of intestinal hormones, such as glucagon-like peptide-1 (GLP-1), on obesity and pre-diabetes, two risk factors for type 2 diabetes and cardiovascular disease.

2 Sep 2009

Biotransformed blueberry juice can function as anti-obesity and anti-diabetic agent

Juice extracted from North American lowbush blueberries, biotransformed with bacteria from the skin of the fruit, holds great promise as an anti-obesity and anti-diabetic agent. The study, published in the International Journal of Obesity, was conducted by researchers from the Universit- de Montr-al, the Institut Armand-Frappier and the Universit- de Moncton who tested the effects of biotransformed juices compared to regular blueberry drinks on mice.

2 Sep 2009

Paper discussing the mechanism of the selective TGR5 agonist INT-777 published in Cell Metabolism

Bile acids are known to be key regulators of lipid, glucose and overall energy metabolism. Bile acid activation of the G protein-coupled receptor TGR5 has been shown to induce energy expenditure in muscle and brown fat, thereby conferring resistance to weight gain.

2 Sep 2009

Brisk walking avoids obesity

Men and women who walk or ride a bike to work appear more fit, and men are less likely to be overweight or obese and have healthier triglyceride levels, blood pressure and insulin levels, according to a report in the July 13 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

1 Sep 2009

GS-101 effective in inhibiting and regressing corneal neovascularisation

Gene Signal, a company focused on developing innovative drugs to manage angiogenesis based conditions, today announced the publication of interim results from a phase II study suggesting that the antisense oligonucleotide GS-101 (eye drops) is safe and effective at inhibiting and regressing corneal neovascularisation (abnormal new blood vessel growth).

1 Sep 2009

Weight-loss surgery prior to pregnancy results in lower prevalence of obesity in children

1 Sep 2009

New study reveals that moderate aerobic exercise improves insulin sensitivity in obese adolescents

A moderate aerobic exercise program, without weight loss, can improve insulin sensitivity in both lean and obese sedentary adolescents, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). Insulin is a hormone produced in the pancreas that permits glucose to enter cells to be used for energy or stored for future use by the body.

1 Sep 2009

Phase II result reveals effectiveness of GS-101 eye drops at inhibiting corneal neovascularisation

1 Sep 2009

Insulin News and Research

Further Reading

OSI Pharmaceuticals initiates two clinical trials with OSI-906 oral insulin-like growth factor-1 receptor inhibitor

Reliable and relevant information needed to rein in the costs of federal health-care programs, says study

Medtronic's COPE-HCV clinical study commences

Validity of Unigene’s patent on Fortical confirmed by the court

Strelitz Diabetes Center awarded a two-year grant for 12-LO research

New device for treating hypoglycemia launched globally

Alloantigen-specific Treg cells targeted for organ transplantation

Novo Nordisk's NCDP provides support for accurate cost and benefit assessments of preventive health

Researchers discover why smoking increases the risk of heart disease and stroke

Walking and biking raise health and fitness levels

Genes that regulate the energy consumption of cells have a different structure and expression in diabetics

Research reveals that dramatic maternal weight loss prevents obesity in their children

Grant awarded to two researchers to study the role of GLP-1 in people at risk for or with diabetes

Biotransformed blueberry juice can function as anti-obesity and anti-diabetic agent

Paper discussing the mechanism of the selective TGR5 agonist INT-777 published in Cell Metabolism

Brisk walking avoids obesity

GS-101 effective in inhibiting and regressing corneal neovascularisation

Weight-loss surgery prior to pregnancy results in lower prevalence of obesity in children

New study reveals that moderate aerobic exercise improves insulin sensitivity in obese adolescents

Phase II result reveals effectiveness of GS-101 eye drops at inhibiting corneal neovascularisation

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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