Insulin Resistance News and Research

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Insulin Resistance is a condition in which the body does not respond to insulin properly. This is most common in Type II diabetes or associated with obesity, ketoacidosis, infection, and certain rare conditions. Diminished effectiveness of insulin in lowering blood glucose levels requiring 200 units or more of insulin per day to prevent hyperglycemia or ketosis.

Issues on cholesterol: diet, statins and genetics

Genetic lipoprotein disorders are frequently seen in patients with premature coronary artery disease (CAD). An example of strong genetic predisposition is the disorder: familial hypercholesterolemia, where a single gene defect (the low density lipoprotein receptor) contributes to most of the familial expression of CAD.

1 Sep 2008

Young type-2 diabetic men suffer low testosterone levels

Young men with type 2 diabetes have significantly low levels of testosterone, endocrinologists at the University at Buffalo have found -- a condition that could have a critical effect on their quality of life and on their ability to father children.

27 Aug 2008

Growth hormone reduces abdominal fat, cardiovascular risk in HIV patients on antiviral therapy

Low-dose growth hormone treatment reduced abdominal fat deposits and improved blood pressure and triglyceride levels in a group of patients with HIV lipodystrophy, a condition involving the redistribution of fat and other metabolic changes in patients receiving combination drug therapy for HIV infection.

3 Aug 2008

Regular meals important for the health

It is obvious to most people that our health is affected by what we eat; now, however, scientists have shown that it is also a matter of how often we eat.

21 Jul 2008

Diet alone cannot control type 2 diabetes

Despite strong evidence that type 2 diabetes can be prevented or at least delayed by a combination of lifestyle changes and good dietary advice, a team of Cochrane Researchers found that there is no indication whether dietary advice alone can prevent the disease.

16 Jul 2008

Insulin suppresses receptors that cause cascade of inflammation

Researchers at the University at Buffalo -- the first to identify the anti-inflammatory and cardioprotective properties of insulin -- now have discovered one pathway through which the hormone produces this effect.

13 Jul 2008

Lipid Association responds to new cholesterol guidelines for kids

When the American Academy of Pediatrics (AAP) issued its recommendation on July 7 regarding the treatment of children with high cholesterol, it generated a strong response from the community of medical professionals and patients. The National Lipid Association (NLA), a group of healthcare professionals who specialize in cholesterol and heart disease issues, believes that the AAP has acted in the interests of patient care by raising the issue of lipid abnormalities in children.

10 Jul 2008

Liver protein fetuin-A linked to type 2 diabetes in seniors

The presence of a protein expressed by the liver which inhibits insulin action may identify individuals more likely to develop type 2 diabetes, according to a new study led by a researcher from the UCSD School of Medicine, to be published July 9 in the Journal of the American Medical Association.

9 Jul 2008

Advanced breast cancer more likely in older women at risk of developing type 2 diabetes

According to new research women who are at risk of developing type 2 diabetes also have a much greater chance of being diagnosed with advanced breast cancer.

7 Jul 2008

Experts say some children are fit and fat and BMI may be misleading

Scientists have questioned UK and U.S. guidelines on children's physical activity levels and say they need revising.

30 Jun 2008

Hypertension, insulin resistance and immune suppression links

Many of the 75 million Americans with essential hypertension also develop diabetes and other complications in addition to their high blood pressure, and researchers have discovered a common molecular mechanism in a strain of rat that explains why such metabolic disorders arise together in mammals.

30 Jun 2008

Growth hormone FGF21's link to starvation may be clue to increasing life span, researchers find

Researchers at UT Southwestern Medical Center have determined that starvation blocks the effects of growth hormone via a mechanism that may have implications in treating diabetes and extending life span.

30 Jun 2008

Prenatal nutrition and nutrition during childhood interact to alter puberty

A high-fat diet during pregnancy and nursing may lead to the child having an early onset of puberty and subsequent adulthood obesity, according to a new animal study. The results were presented Monday, June 16, at The Endocrine Society's 90th Annual Meeting in San Francisco.

16 Jun 2008

How to reduce obesity and cardiovascular disease risk

Changes in society are leading to a sedentary lifestyle and are causing a rise in the number of people with obesity and cardiovascular disease. This is consequently having a large impact on the health of the nation.

15 Jun 2008

Study looks at the role of metformin as possible anti-tumor agent

Metformin, the common first-line drug for type 2 diabetes, may be effective in increasing pathologic complete response rates in diabetic women with early stage breast cancer who took the drug during chemotherapy prior to having surgery, paving the way for further research of the drug as a potential cancer therapy, according to researchers at The University of Texas M. D. Anderson Cancer Center.

2 Jun 2008

How cells size up their growth opportunities

The intricate mechanisms that switch cell growth on and off are regulated by mammalian target of rapamycin (mTOR) protein complexes, which sense nutrients within the cell. When amino-acids are abundant, the protein complexes promote cellular growth, and when nutrients are scarce they signal that hard times are ahead to the cell. But just how nutrients regulate mTOR signaling to control size has remained a mystery. Now, scientists in the lab of Whitehead Member David Sabatini have found the first step in the process.

25 May 2008

Demand for alternative sweeteners are increasing by 8% a year

The demand for alternative sweeteners to sugar is increasing at a rate of 8% per year. The market is showing more and more interest in natural sweeteners compared to synthetic ones. This has been reflected in a study carried out by researchers at the Universidad Miguel Hernández (UMH) in Elche, Alicante.

12 May 2008

Joslin researchers find certain body fat reduces insulin resistance

It has long been known that type 2 diabetes is linked to obesity, particularly fat inside the belly. Now, researchers at the Joslin Diabetes Center have found that fat from other areas of the body can actually reduce insulin resistance and improve insulin sensitivity.

6 May 2008

Gene sequence that can make half of us fatter is discovered

A gene sequence linked to an expanding waist line, weight gain and a tendency to develop type 2 diabetes has been discovered as part of a study published today in the journal Nature Genetics.

6 May 2008

Aspirin-like compounds (salicylates) increase insulin secretion in otherwise healthy obese people

Aspirin-like compounds (salicylates) can claim another health benefit: increasing the amount of insulin produced by otherwise healthy obese people. Obesity is associated with insulin resistance, the first step toward type 2 diabetes.

29 Apr 2008