Interferons News and Research

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The causative role of age-associated pre-existing senescent cells on COVID-19 severity

Researchers investigated the role of senescent cells in the context of SARS-CoV-2 infection.

10 Jul 2023

Understanding Lupus: an interview with the Garvan Institute

To commemorate World Lupus Day, we spoke to Elissa Deenick, co-lead of the Precision Immunology Program at the Garvan Institute, about the current state of lupus understanding and what needs to happen to make lupus visible.

9 May 2023

Study reveals CMPK-2 protein-coding gene as a potent inhibitor of flaviviruses

CMPK2 identified as a potential pan-flavivirus inhibitor, restricting virus replication and providing a basis for developing new antiviral treatments.

23 Apr 2023

Gestational obesity plus zika virus infection can compromise placenta’s immune response

Researchers at the University of São Paulo (USP) in Brazil have shown for the first time that gestational obesity associated with infection by zika virus influences the placenta's antiviral response, weakening the organ's capacity to attack the pathogen and protect the fetus.

20 Apr 2023

Omicron BA.5 variant demonstrates increased neuroinvasiveness and pathogenicity in mice

Researchers assessed the extent of SARS-CoV-2 Omicron VOC BA.5 sub-VOC infection-associated brain infection and death.

5 Apr 2023

Poor inflammatory immune response in obese patients increases susceptibility to severe COVID-19

Individuals who are obese may be more susceptible to severe COVID-19 because of a poorer inflammatory immune response, say Cambridge scientists.

20 Mar 2023

How does temperature affect host responses to SARS-CoV-2 and IAV infection in human nasal epithelial cells?

A new preprint examines the response to these pathogens in the nose, which is the primary portal of entry for both.

13 Mar 2023

Important backup mechanism of human immune cells elucidated

The enzyme TBK1 is an important component of the innate immune system that plays a critical role in the defense against viruses.

10 Mar 2023

Self-directed autoantibodies against certain chemokines may protect against long-COVID

A recent study published in the journal Nature Immunology discovered autoantibodies against chemokines following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

8 Mar 2023

Rockefeller scientists describe the genetics of severe SARS-CoV-2 infection in children

One of the most terrifying aspects of the COVID pandemic has been its unpredictably severe impact on some children.

10 Feb 2023

What are the major findings of long COVID research?

Researchers explored existing literature on long coronavirus disease (COVID). They highlighted key immunological findings, similarities with other diseases, symptoms, and associated pathophysiological mechanisms, and diagnostic and therapeutic options, including COVID-19 vaccinations.

17 Jan 2023

An epigenetic modification improves the defense against infections, research shows

During infections, the hematopoietic system switches from normal to emergency mode. This improves the defense against the pathogens.

9 Dec 2022

What are the associations of metabolome, microbiome, and immune perturbations with severe COVID-19?

In a new study, researchers observed that coronavirus disease 2019 (COVID-19) progression and inflammatory responses are associated with changes in the metabolome and microbiome.

8 Dec 2022

Detection of filoviruses by the innate immune system

In a new study, researchers examined how the innate immune system detects filoviruses.

1 Dec 2022

Study suggests persistent immune activation and long COVID correlate independently with severe COVID-19

Researchers investigated whether severe COVID-19 patients exhibited inflammation and immune activation three months after hospitalization and explored the associations among COVID-19 severity, long COVID, and immune activation.

30 Nov 2022

Pediatric acute myeloid leukemia genetic subtypes with poor outcomes show increased inflammatory cytokine signaling

Researchers used ribonucleic acid (RNA) sequence data to understand the association between inflammatory cytokines and poor outcomes of pediatric Acute Myeloid Leukemia (pAML).

29 Nov 2022

How SARS-CoV-2 immune responses vary by population due to environmental and genetic factors

Researchers investigate the genetic, immunological, and evolutionary factors that determine the vast variability observed in clinical manifestations of COVID-19.

28 Nov 2022

SARS-CoV-2 RNA levels, IFN-1, ISGs, and NF-κB gene responses within the respiratory tract of mild and severe COVID-19 patients

Researchers characterized the expression of IFN-1 and IFN-2, ISGs, and NF-κB in the upper respiratory tracts of patients with mild and severe COVID-19, to understand innate immune responses to SARS-CoV-2 infections.

17 Nov 2022

Study of natural killer lymphocytes transcriptionally reprogrammed by vaccinia virus

In a recent study posted to the bioRxiv* preprint server, researchers evaluated responses of natural killer (NK) lymphocytes to VACV (vaccinia virus) infections in vivo.

16 Nov 2022

New discovery reveals which patients will survive longer after receiving immunotherapy

Patients with head and neck cancer who have more genetic material on chromosome 9 in their cancer cells survive three times longer after receiving immunotherapy than those with less genetic material there, a new study finds.

14 Nov 2022