Interleukin 4 News and Research

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Oxford-AstraZeneca COVID-19 vaccine induces robust T cell-based immunity

A recent study conducted by an international team of scientists has revealed that the Oxford-AstraZeneca coronavirus disease 2019 (COVID-19) vaccine, AZD1222, is capable of inducing strong spike-specific CD4+ T cell helper type 1 (Th1) and CD8+ T-cell responses in vaccinated individuals. A detailed description of AZD1222-induced cellular immunity is currently available on the medRxiv* preprint server.

28 Jun 2021

Anti-inflammatory nanoparticles could be applied to the weakening muscles of DMD patients

Muscular dystrophies are a group of genetic diseases that lead to the progressive loss of muscle mass and function in patients, with the incurable Duchenne Muscular Dystrophy (DMD), which affects all the body's muscles primarily in boys, being particularly severe.

25 Jun 2021

CD39+ monocyte count higher in pregnant than non-pregnant COVID-19 patients

A new study published on the bioRxiv* server describes the changes in the representation of a subset of activated monocytes in this group of patients.

23 Jun 2021

Increased severity of COVID-19 in pregnancy

A new preprint on the medRxiv* server provides more evidence that COVID-19 likely causes a more serious phenotype to arise in pregnant women.

23 Jun 2021

Study examines the role of spirituality in health, well-being of breast cancer survivors

Throughout her 20-year career as a nurse practitioner, Jennifer Hulett noticed survivors of breast cancer would often express gratitude for being alive and mention God or a divine acknowledgement that had improved their health and well-being.

23 Jun 2021

Can antioxidants help manage neurological complications in COVID-19?

In a recent study published in Antioxidants, researchers evaluated the use of antioxidants as potential adjuvants for the treatment of COVID-19.

23 Jun 2021

Switching to a balanced diet restores gut health and suppresses skin inflammation

The secret to healthier skin and joints may reside in gut microorganisms. A study led by UC Davis Health researchers has found that a diet rich in sugar and fat leads to an imbalance in the gut's microbial culture and may contribute to inflammatory skin diseases such as psoriasis.

22 Jun 2021

Eating prunes daily can improve risk factors for cardiovascular disease in postmenopausal women

New research published in the Journal of Medicinal Food suggests eating prunes each day can improve risk factors for cardiovascular disease (CVD) including raising antioxidant capacity and reducing inflammation among healthy, postmenopausal women.

22 Jun 2021

Study determines the mechanism behind respiratory inflammation and finds effective treatment

Applied Biological Laboratories (Applied Bio), a biopharmaceutical company focused on the respiratory disease market, announced that its study published online in Immunology, Inflammation and Disease was able to determine the mechanism behind respiratory inflammation and treat it effectively with Biovanta(TM), a 100% naturally derived, over-the-counter (OTC) drug for cold, cough and sore throat.

22 Jun 2021

Western diet increases COVID-19 severity in a hamster model

Researchers have shown that a Western diet may affect viral replication, disease severity, and immune protection following infection with SARS-CoV-2.

21 Jun 2021

Targeting lung inflammation with cell membrane-based dexamethasone nanodelivery platform

Recently, researchers discuss their development of cell membrane-based nanoparticles that successfully delivered dexamethasone directly to inflamed lung cells.

21 Jun 2021

Blocking IL-11 signaling can promote liver regeneration after paracetamol-induced damage

Scientists at Duke-NUS Medical School and National Heart Centre Singapore, in collaboration with colleagues in Singapore and the UK, have shown that the human form of the signaling protein interleukin 11 (IL-11) has a damaging effect on human liver cells--overturning a prior hypothesis that it could help livers damaged by paracetamol poisoning.

18 Jun 2021

Baseline use of DMARDs linked with COVID-19 severity in rheumatoid arthritis patients

Due to sample size limitations, previous studies of DMARD use and COVID-19 outcomes have combined several different rheumatic diseases and medications, and investigated a single outcome- for example, the risk of hospitalization.

18 Jun 2021

Could a fungus-derived compound reduce hyperinflammation in severe COVID-19?

New research from scientists at the University of Pennsylvania, USA, demonstrates that cyclosporine A (CSA), a calcineurin inhibitor that modulates cytokine production, may have potential antiviral properties against coronaviruses.

18 Jun 2021

Protein found in mice’s immune system could protect babies from necrotizing enterocolitis

The intestinal disease necrotizing enterocolitis is a leading cause of death among premature infants born in the U.S. and across the globe.

18 Jun 2021

Cinnamon compound could be useful supplement to dexamethasone in COVID-19 treatment

Researchers in Germany and the United States have conducted a study showing that supplementing dexamethasone treatment with Ceylon cinnamon in cases of coronavirus disease 2019 (COVID-19) may allow dexamethasone to be administered at lower doses, thereby avoiding the side effects that occur with high doses of the steroid.

17 Jun 2021

The role of natural killer cells in fight against viral infections including SARS-CoV-2

In an effort to further understand the role of NK cells in combatting COVID-19, a group of researchers explored NK cells in acute viral infections, citing flavivirus and influenza virus infections as examples.

17 Jun 2021

SARS-CoV-2 oral vaccine booster shows promise in animal tests

In a recent study published on the pre-print bioRxiv* server, a group of Israeli researchers discusses their progress towards developing an oral multi-antigen SARS-CoV-2 vaccine.

15 Jun 2021

Potent antibodies against SARS-CoV-2 can be produced without T follicular helper cells, suggests study

It has been uncertain whether antibodies produced via this non-canonical pathway are protective against SARS-CoV-2. In a new study, recently released as a preprint on the bioRxiv*server, the neutralization potency of these antibodies is compared with those traditionally produced in germinal center-based antiviral responses.

15 Jun 2021

Immune memory responses differ between SARS-CoV-2 and influenza A

Researchers in Canada have shown that the long-lasting immunity that develops following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by different T cell responses than those observed for influenza A virus-specific immune memory.

14 Jun 2021

Interleukin 4 News and Research

Oxford-AstraZeneca COVID-19 vaccine induces robust T cell-based immunity

Anti-inflammatory nanoparticles could be applied to the weakening muscles of DMD patients

CD39+ monocyte count higher in pregnant than non-pregnant COVID-19 patients

Increased severity of COVID-19 in pregnancy

Study examines the role of spirituality in health, well-being of breast cancer survivors

Can antioxidants help manage neurological complications in COVID-19?

Switching to a balanced diet restores gut health and suppresses skin inflammation

Eating prunes daily can improve risk factors for cardiovascular disease in postmenopausal women

Study determines the mechanism behind respiratory inflammation and finds effective treatment

Western diet increases COVID-19 severity in a hamster model

Targeting lung inflammation with cell membrane-based dexamethasone nanodelivery platform

Blocking IL-11 signaling can promote liver regeneration after paracetamol-induced damage

Baseline use of DMARDs linked with COVID-19 severity in rheumatoid arthritis patients

Could a fungus-derived compound reduce hyperinflammation in severe COVID-19?

Protein found in mice’s immune system could protect babies from necrotizing enterocolitis

Cinnamon compound could be useful supplement to dexamethasone in COVID-19 treatment

The role of natural killer cells in fight against viral infections including SARS-CoV-2

SARS-CoV-2 oral vaccine booster shows promise in animal tests

Potent antibodies against SARS-CoV-2 can be produced without T follicular helper cells, suggests study

Immune memory responses differ between SARS-CoV-2 and influenza A

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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