Interleukin 6 News and Research

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Interleukin-6 (IL-6) is a protein that in humans is encoded by the "IL6" gene. IL-6 is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation.

New therapeutic approach for preventing Alzheimer's disease

Pathological changes typical of Alzheimer's disease were significantly reduced in mice by blockade of an immune system transmitter. A research team from Charité - Universitätsmedizin Berlin and the University of Zurich has just published a new therapeutic approach in fighting Alzheimer's disease in the current issue of Nature Medicine. This approach promises potential in prevention, as well as in cases where the disease has already set in.

26 Nov 2012

Turning off particular cytokines reduces Alzheimer's typical amyloid-- deposits in mice

Alzheimer's disease is one of the most common causes of dementia. In Germany and Switzerland alone, around 1.5 million people are affected, and forecasts predict a doubling of the number of patients worldwide within the next 20 years. The accumulation of particular abnormal proteins, including amyloid-- (Aβ) among others, in patients' brains plays a central role in this disease.

26 Nov 2012

Lymphopenia driven diseases and the orphan drug industry: an interview with Damian Marron, CEO of Cytheris

Lymphopenia is when you lack the T cells of your immune system. T cells are very important for controlling infection. Probably the most known cause of lymphopenia is HIV.

23 Nov 2012

Glycoprotein gene flags up heart disease

The glycosylphosphotidylinositol-anchored membrane glycoprotein CD14 gene significantly predicts cardiovascular mortality in adults aged 65 years or over, research shows.

20 Nov 2012

IL-13 receptor system could play a major role in Parkinson's

Deciphering what causes the brain cell degeneration of Parkinson's disease has remained a perplexing challenge for scientists. But a team led by scientists from The Scripps Research Institute (TSRI) has pinpointed a key factor controlling damage to brain cells in a mouse model of Parkinson's disease.

20 Nov 2012

Study illuminates how Aldo and galectin-3 protein contribute to vascular remodeling, CHF

Cardiovascular disease will kill nearly 2.5 million people in the United States this year, according to the Centers for Disease Control. Over time, inflammation, collagen deposition and scar tissue formation can cause blood vessels to stiffen, a process called vascular fibrosis. Though researchers have known that the hormone aldosterone (Aldo) plays a role in this process, the precise mechanisms have been poorly understood.

17 Nov 2012

Hydrocortisone protects bilateral knee replacement patients

Repeat doses of corticosteroids may protect patients undergoing bilateral total knee arthroplasty from postoperative side effects such as fever, pain, and acute respiratory distress, research suggests.

16 Nov 2012

Positive preliminary results from ImmunoPulse Phase II trial in metastatic melanoma

OncoSec Medical Inc., a company developing its advanced-stage ImmunoPulse DNA-based immunotherapy and NeoPulse therapy to treat solid tumors, announces positive preliminary results from a Phase II trial investigating the use of ImmunoPulse in metastatic melanoma patients at the 6th World Meeting of Interdisciplinary Melanoma Skin Cancer Centres & 8th EADO Congress.

15 Nov 2012

Study indicates that impact of early-life abuse extend well into older age

The psychological scars of childhood abuse can last well into adulthood. New research from Concordia University shows the harm can have longterm negative physical effects, as well as emotional ones.

14 Nov 2012

Neuroticism can be good for health under certain circumstances

Under certain circumstances neuroticism can be good for your health, according to a University of Rochester Medical Center study showing that some self-described neurotics also tended to have the lowest levels of Interleukin 6 (IL-6), a biomarker for inflammation and chronic disease.

14 Nov 2012

Study explores impact of IL1β on brain function alterations associated with schizophrenia

There are a growing number of clues that immune and inflammatory mechanisms are important for the biology of schizophrenia. In a new study in Biological Psychiatry, Dr. Mar Fatjó-Vilas and colleagues explored the impact of the interleukin-1β gene (IL1β) on brain function alterations associated with schizophrenia.

2 Nov 2012

Researchers decode software instructions that drive 3 different forms of acute lymphoblastic leukemia

30 Oct 2012

Scientists decode epigenetic programming of three virulent forms of acute lymphoblastic leukemia

A team of national and international researchers, led by Weill Cornell Medical College scientists, have decoded the key "software" instructions that drive three of the most virulent forms of acute lymphoblastic leukemia (ALL). They discovered ALL's "software" is encoded with epigenetic marks, chemical modifications of DNA and surrounding proteins, allowing the research team to identify new potential biomarkers and therapeutic targets.

29 Oct 2012

Interim results from CEL-SCI's Multikine Phase III study on head and neck cancer

CEL-SCI Corporation announced today that an interim review of the safety data from its open label, randomized, controlled, pivotal Phase III study of Multikine (Leukocyte Interleukin, Injection) investigational immunotherapy by an Independent Data Monitoring Committee (IDMC) raised no safety concerns.

23 Oct 2012

$Ustekinumab success in refractory Crohn’s disease$

Ustekinumab success in refractory Crohn’s disease

Patients with Crohn’s disease who have failed to respond adequately to anti–tumor necrosis factor treatment may benefit from the monoclonal antibody ustekinumab, results of a double-blind, placebo-controlled trial suggest.

22 Oct 2012

Fungal exposure in homes could increase risk of sarcoidosis

People who are exposed to mold in their homes could be at an increased risk for sarcoidosis, a chronic inflammatory lung disease. Researchers from Sweden and Slovenia tested 62 nonsmoking patients with sarcoidosis, 34 of whom had extrapulmonary manifestations (EPM).

22 Oct 2012

Interleukin 6 News and Research

Further Reading

New therapeutic approach for preventing Alzheimer's disease

Turning off particular cytokines reduces Alzheimer's typical amyloid-- deposits in mice

Lymphopenia driven diseases and the orphan drug industry: an interview with Damian Marron, CEO of Cytheris

Glycoprotein gene flags up heart disease

IL-13 receptor system could play a major role in Parkinson's

Study illuminates how Aldo and galectin-3 protein contribute to vascular remodeling, CHF

Hydrocortisone protects bilateral knee replacement patients

Positive preliminary results from ImmunoPulse Phase II trial in metastatic melanoma

Study indicates that impact of early-life abuse extend well into older age

Neuroticism can be good for health under certain circumstances

Study explores impact of IL1β on brain function alterations associated with schizophrenia

Researchers decode software instructions that drive 3 different forms of acute lymphoblastic leukemia

Scientists decode epigenetic programming of three virulent forms of acute lymphoblastic leukemia

Interim results from CEL-SCI's Multikine Phase III study on head and neck cancer

Ustekinumab success in refractory Crohn’s disease

Fungal exposure in homes could increase risk of sarcoidosis

ACT TIL therapy effective in treating metastatic melanoma

Ustekinumab shows positive results in decreasing debilitating effects of Crohn's Disease

Cytokine levels altered in FEP, schizophrenia patients

Companionship can reduce nerve-related pain

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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