Intrauterine Growth Restriction News and Research

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Researchers grow human trophoblast stem cells for the first time

In a milestone achievement for better understanding the development and function of the human placenta, scientists have derived and grown trophoblast stem cells for the first time.

24 Jan 2018

Folic acid supplementation during late pregnancy may increase risk of allergies in offspring

A new study suggests that taking folic acid in late pregnancy may increase the risk of allergies in offspring affected by intrauterine growth restriction.

21 Dec 2017

Anti-impotence drug found to be ineffective at improving outcomes for IUGR pregnancies

A University of Liverpool led international clinical trial has found an anti-impotence drug to be ineffective at improving outcomes for pregnancies complicated by fetal growth restriction.

8 Dec 2017

History of kidney stones linked to higher risk for metabolic, hypertensive complications during pregnancy

Results from a new study suggest that a history of kidney stones may indicate an increased risk for metabolic and hypertensive complications during pregnancy and add support to a growing body of research linking kidney stones with systemic diseases such as diabetes and cardiovascular disease.

6 Nov 2017

Scientists identify key gene in 22q11.2 that contributes to genitourinary birth defects

The 22q11.2 region of human chromosome 22 is a hotspot for a variety of birth defects. Scientists learned about this region because it is deleted in about 1 in 4,000 births, causing the loss or duplication of up to 40 genes.

25 May 2017

Specific genetic changes in the placenta of women may serve as biomarker to predict newborn health

UCLA scientists have discovered specific genetic changes in the placentas of women who gave birth to growth-restricted infants. These changes appear to sabotage the ability of the placenta to grow blood vessels and adequately nourish the fetus, interfering with the infant's growth in the womb.

3 May 2017

Zika virus can cause a range of abnormalities in pregnant women, study finds

New research presents strong evidence that the Zika virus can indeed cause a range of abnormalities in pregnant women infected with the virus -- with the effects manifesting any time during pregnancy. Some of the abnormalities noted have not been reported in connection with the virus.

7 Mar 2016

Maternal smoking affects long-term health of male offspring

Mothers who smoke are putting more than their own health at risk, suggests a study published today in BJOG: an International Journal of Obstetrics and Gynaecology. Young men whose mothers smoked during pregnancy had lower aerobic fitness compared to those whose mothers did not.

9 Dec 2015

Researchers successfully convert skin cells into fully functional placenta-generating cells

Regenerative medicine is a new and expanding area that aims to replace lost or damaged cells, tissues or organs in the human body through cellular transplantation. Embryonic stem cells (ESCs) are pluripotent cells that are capable of long-term growth, self-renewal, and can give rise to every cell, tissue and organ in the fetus's body.

15 Oct 2015

Current fetal growth standards do not consider racial and ethnic differences

Current standards for ultrasound evaluation of fetal growth may lead to misclassification of up to 15 percent of fetuses of minority mothers as being too small, according to a study by researchers at the National Institutes of Health (NIH) and other institutions.

29 Sep 2015

WSU researcher secures $1.25 million NIH grant to study role of rosiglitazone drug in reversing preeclampsia

Sascha Drewlo, Ph.D., assistant professor of obstetrics and gynecology for the Wayne State University School of Medicine, has secured a $1.25 million grant from the National Heart, Lung and Blood Institute of the National Institutes of Health to study the role of approved drugs to improve placental function.

8 Jul 2015

Researchers review ten years of scientific studies on mitochondrial toxicity in pregnant women

Researchers from the Hospital Clinic of Barcelona (Spain) have reviewed ten years' worth of scientific studies on mitochondrial toxicity in pregnant women. Exposure to toxic agents such as viruses, certain drugs, pesticides, alcohol and tobacco cause mitochondrial diseases about which very little is known, and which are transmitted from the mother to the foetus.

20 Feb 2015

Opioid abuse in pregnant women increases 127% in 14 years

The number of pregnant women who abuse or are dependent on opioids (narcotics) jumped 127 percent in 14 years, leading to an increased risk of maternal death and stillbirth among other serious problems, according to a review of more than 57 million American women admitted for delivery.

19 Nov 2014

Preeclampsia study provides pathways for new therapeutic treatments

A team of researchers led by a Wayne State University School of Medicine associate professor of obstetrics and gynecology has published findings that provide novel insight into the cause of preeclampsia, the leading cause of maternal and infant death worldwide, a discovery that could lead to the development of new therapeutic treatments.

27 Oct 2014

Infant and adult weight interact to determine urinary incontinence risk

A woman’s weight at birth together with her weight in adulthood influence the risk of incident urinary incontinence, results of a nationwide twin study suggest.

28 May 2014

Study shows relative increase of 322% for severe pre-eclampsia

A latest study by researchers at the Mailman School of Public Health and Columbia University Medical Center reports that pre-eclampsia, characterized by an elevation in the blood pressure and excess protein in the urine of pregnant women, has a 1.5-fold to 2-fold higher incidence in first pregnancies. The condition, which causes complications in approximately 3-6% of all pregnancies, is also associated with high risks of preterm delivery, intrauterine growth restriction, placental abruption, and perinatal mortality. Findings are published online in the British Medical Journal.

22 Nov 2013

Biomarker may predict poor pregnancy outcomes in lupus patients

Researchers at Hospital for Special Surgery in New York City have identified a biomarker that may predict poor pregnancy outcomes in lupus patients.

28 Oct 2013

Antenatal taurine reduces cerebral cell apoptosis in fetal rats with intrauterine growth restriction

Increased brain cell apoptosis in intrauterine growth-restricted fetal rats is a key reason for unfavorable long-term prognosis of the nervous system. The harmful effects of intrauterine growth restriction on fetal brain development originate in the womb.

6 Sep 2013

Samoan epidemic of obesity may start with rapid weight gain in early infancy

As some Pacific island cultures have "westernized" over the last several decades, among the changes has been a dramatic increase in obesity. Researchers don't understand all the reasons why, but even a decade ago in American Samoa 59 percent of men and 71 percent of women were obese. A new Brown University study finds that the Samoan epidemic of obesity may start with rapid weight gain in early infancy.

6 Feb 2013

Isolated fetal echogenic bowel ‘may be benign’

Results of a Dutch study show that the majority of fetuses with fetal echogenic bowel carry a good prognosis.

9 Oct 2012