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New vaccine promotes immune regulation that treats autoimmunity and prolongs transplant survival

A subtype of CD8 T cells, which are classically known to promote immune system responses, may be in fact regulating the immune system by suppressing immune cells causing self-destructive responses leading to autoimmune disorders and organ graft rejection.

15 Nov 2023

UVA researchers receive NIH grant to optimize online weight-management programs for rural residents

University of Virginia School of Medicine public health researchers, together with colleagues at the University of South Carolina, have received a $3.37 million grant from the National Institutes of Health to determine if online behavioral weight-management programs for rural residents can be improved by adding a human touch.

15 Nov 2023

Adult children discuss the trials of caring for their aging parents

I am 39 years old. I had to care for my father, who passed from cancer in 2019; my mother, who passed in November 2021 from cancer; and since my mother's passing, I have inherited the care of my grandmother.

14 Nov 2023

Facing financial ruin as costs soar for elder care

Margaret Newcomb, 69, a retired French teacher, is desperately trying to protect her retirement savings by caring for her 82-year-old husband, who has severe dementia, at home in Seattle.

14 Nov 2023

Study shows environment's pivotal role in healthy aging and disease prevention

Study explores new geroscience tools for studying the impact of environmental factors on aging, aiming to delay age-related diseases and disabilities. It highlights how non-genetic factors, like environmental toxins and socio-economic conditions, significantly influence aging and health outcomes.

13 Nov 2023

Intensive blood pressure treatment lowers risk of cardiovascular events in high-risk patients

An intensive three-year intervention to lower the top blood pressure number to less than 120 mm Hg was more effective at preventing death, heart attack, stroke and other cardiovascular events in adults at high risk for cardiovascular disease, compared to the standard treatment target of under 140 mm Hg, according to late-breaking science presented today at the American Heart Association's Scientific Sessions 2023.

13 Nov 2023

New drug zilebesiran effectively lowers blood pressure for six months, study finds

A single injection of the experimental medication zilebesiran was safe and effective in reducing systolic blood pressure in people with mild-to-moderate high blood pressure for up to six months, as detailed in the Phase 2 of the KARDIA study, reported as late-breaking science today at the American Heart Association's Scientific Sessions 2023.

13 Nov 2023

Pioneering study finds predictive biomarker in lung adenocarcinoma

The potential of the transcriptome of tumor-adjacent normal lung tissue in predicting the prognosis of lung cancer.

13 Nov 2023

SELECT trial: Semaglutide reduces cardiovascular events by 20% in overweight or obese patients without diabetes

Findings from a multi-center, international clinical trial reported by a Cleveland Clinic physician show that semaglutide reduced cardiovascular events by 20% in adults with overweight or obesity and established cardiovascular disease who do not have diabetes.

13 Nov 2023

Liberal blood transfusion may reduce recurrence risk, improve survival in heart attack patients with anemia

An international clinical trial led by physician Jeffrey L. Carson, distinguished professor of medicine at Rutgers Robert Wood Johnson Medical School, found that a liberal blood transfusion given to patients who have had a heart attack and have anemia may reduce the risk of a reoccurrence and improve survival rates.

12 Nov 2023

Obinutuzumab shows promise in preserving kidney function, preventing flares in lupus nephritis patients

In a post hoc analysis of the phase 2 NOBILITY trial, researchers found that treatment with obinutuzumab-;an antibody that targets a protein expressed on certain immune cells-;was superior to placebo for preserving kidney function and preventing flares in patients with lupus nephritis, a kidney condition associated with the autoimmune disease lupus.

10 Nov 2023

New calculator estimates a person’s cardiovascular disease risk over the next 30 years

A new calculator estimates a person's risk for cardiovascular disease (CVD) over the next 30 years by combining measures of cardiovascular, kidney and metabolic health for the first time, according to a new American Heart Association Scientific Statement published today in the Association's flagship journal Circulation.

10 Nov 2023

Tumor-immune interactions predict treatment responses in multiple myeloma

A multicenter study led by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine shows how interactions between tumor cells and immune components of the microenvironment can impact treatment responses and outcomes in patients newly diagnosed with multiple myeloma who undergo combination treatments that include targeted immunotherapy.

9 Nov 2023

Scientists discover kidney-friendly antifungal that evades resistance

In this investigation, researchers produced powerful antifungals of the polyene class without nephrotoxicity.

9 Nov 2023

Individuals with severe mental illness are at higher risk of experiencing physical multimorbidity

A new study published in BMJ Mental Health has found that individuals with severe mental illness are almost twice as likely to report physical multimorbidity, emphasizing the critical importance of addressing the intersection between mental and physical health.

9 Nov 2023

Live shingles vaccine highly effective in the first year after vaccination and then wanes substantially

The effectiveness of live zoster (shingles) vaccine is highest in the first year after vaccination and then wanes substantially.

8 Nov 2023

New antifungal molecule shows promise in combatting fungal infections without toxicity

A new antifungal molecule, devised by tweaking the structure of prominent antifungal drug Amphotericin B, has the potential to harness the drug's power against fungal infections while doing away with its toxicity, researchers at the University of Illinois Urbana-Champaign and collaborators at the University of Wisconsin-Madison report in the journal Nature.

8 Nov 2023

Diabetes breakthrough: Scientists uncover novel route to stimulate beta cell growth

Researchers at Weill Cornell Medicine have uncovered a novel route to stimulate the growth of healthy insulin-producing pancreatic beta cells in a preclinical model of diabetes.

8 Nov 2023

Study shows linear associations between body mass index and site-specific tumors in young males

The associations between body mass index (BMI) among young males and new-onset site-specific tumors.

8 Nov 2023

CAR-T cell therapy could lead to sustained suppression of autoantibodies in treatment-resistant lupus

New research at ACR Convergence 2023, the American College of Rheumatology's annual meeting, demonstrates that CAR-T cell therapy could lead to sustained suppression of autoantibodies in treatment-resistant lupus while maintaining a robust response to vaccines.

7 Nov 2023

Kidney News and Research

New vaccine promotes immune regulation that treats autoimmunity and prolongs transplant survival

UVA researchers receive NIH grant to optimize online weight-management programs for rural residents

Adult children discuss the trials of caring for their aging parents

Facing financial ruin as costs soar for elder care

Study shows environment's pivotal role in healthy aging and disease prevention

Intensive blood pressure treatment lowers risk of cardiovascular events in high-risk patients

New drug zilebesiran effectively lowers blood pressure for six months, study finds

Pioneering study finds predictive biomarker in lung adenocarcinoma

SELECT trial: Semaglutide reduces cardiovascular events by 20% in overweight or obese patients without diabetes

Liberal blood transfusion may reduce recurrence risk, improve survival in heart attack patients with anemia

Obinutuzumab shows promise in preserving kidney function, preventing flares in lupus nephritis patients

New calculator estimates a person’s cardiovascular disease risk over the next 30 years

Tumor-immune interactions predict treatment responses in multiple myeloma

Scientists discover kidney-friendly antifungal that evades resistance

Individuals with severe mental illness are at higher risk of experiencing physical multimorbidity

Live shingles vaccine highly effective in the first year after vaccination and then wanes substantially

New antifungal molecule shows promise in combatting fungal infections without toxicity

Diabetes breakthrough: Scientists uncover novel route to stimulate beta cell growth

Study shows linear associations between body mass index and site-specific tumors in young males

CAR-T cell therapy could lead to sustained suppression of autoantibodies in treatment-resistant lupus

One Health, One Mission: The World Organisation for Animal Health on the AMR Frontline

Uniting Against Resistance: The World Health Organization for World Antimicrobial Awareness Week 2023

Tackling Antimicrobial Resistance: A Conversation with Dr. Beverley Isherwood

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