Kinase News and Research

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Genetic influences on addictions - new findings

Previous research has extensively studied the association of the dopamine D2 receptor gene (DRD2) with alcoholism.

25 Sep 2007

Study reveals the regulatory mechanism of protein kinase A

Research conducted at the University of California, San Diego (UCSD) School of Medicine has shed new light on the structure and function of one of the key proteins in all mammalian cells, protein kinase A (PKA), an enzyme which plays an essential role in memory formation, communication between nerve cells, and cardiac function.

21 Sep 2007

Brugia malayi's secrets revealed

An international team of researchers has revealed the genetic secrets of one of the world's most debilitating human parasites, Brugia malayi (B. malayi), which the World Health Organization estimates has seriously incapacitated and disfigured more than 40 million people around the globe.

21 Sep 2007

Modulating fat levels essential for successful pregnancy

New data, generated in mice by Richard Proia and colleagues at the National Institutes of Health, Bethesda, provides a potential reason for early pregnancy loss in humans.

21 Sep 2007

JAK genes and cancer

Cancer-causing genes can work in more powerful and sneaky ways than have been realized.

18 Sep 2007

Study suggests brain tumors need treatment with multiple 'targeted' drugs

Researchers at Dana-Farber Cancer Institute have shown that several, rather than just one, cell-growth switches are simultaneously overactive in many brain tumors and other solid tumors, explaining why treatment with just a single "targeted" switch-blocking drug often yields disappointing results.

13 Sep 2007

Breast cancer drug tamoxifen helps treat symptoms of bipolar disease

Government researchers in the United States have found that the breast cancer drug tamoxifen helped treat the manic symptoms of bipolar disease.

13 Sep 2007

Tamoxifen for bipolar disorder

The medication tamoxifen, best known as a treatment for breast cancer, dramatically reduces symptoms of the manic phase of bipolar disorder more quickly than many standard medications for the mental illness, a new study shows.

13 Sep 2007

Mechanism identified that plays a critical role in multiple myeloma cell cycle and survival

Researchers at Emory University's Winship Cancer Institute are the first to discover a mechanism that plays a critical role in the multiple myeloma cell cycle and survival.

11 Sep 2007

Congestive heart failure is rare among leukemia patients who take imatinib

Congestive heart failure rarely occurs among leukemia patients who take imatinib, researchers at The University of Texas M. D. Anderson Cancer Center found after an exhaustive review of the detailed medical histories of 1,276 patients who enrolled in clinical trials for the drug.

10 Sep 2007

Genetics of imatinib resistance in acute lymphoblastic leukemia

In the September 15th issue of Genes & Development, Drs. Richard T. Williams, Willem den Besten, and Charles J. Sherr at Howard Hughes Medical Institute, St. Jude Children's Research Hospital in Memphis TN, lend new insights into how an aggressive form of acute lymphoblastic leukemia (ALL) develops, and how sensitivity to the targeted chemotherapeutic drug, imatinib, can be diminished through interactions between tumor cells and the host microenvironment.

30 Aug 2007

FDA grants orphan drug designation to TREANDA

Cephalon, Inc. announced today that the U.S. Food and Drug Administration (FDA) Office of Orphan Products Development granted orphan drug designation for the company's investigational therapy, TREANDA (bendamustine HCl), for the treatment of chronic lymphocytic leukemia (CLL).

29 Aug 2007

New understanding of what makes a major global bacterial infection deadly

Researchers believe they have discovered why a bacterial lung infection is so lethal in the early stages, and it's not what medical authorities had thought, according to research published in the journal Immunity.

28 Aug 2007

New way to control hypertension may lead to more effective drugs

British scientists say they have found a new way to regulate hypertension (high blood pressure).

27 Aug 2007

Potential new leukemia drug

In a new study, Danilo Perrotti and colleagues from Ohio State University, Columbus, show that treatment with a drug known as FTY720 prevents disease in a mouse model of many leukemias caused by the cancer protein BCR-ABL (nearly all cases of blast crisis chronic myeloid leukemia [CML-BC] and some cases of acute lymphocytic leukemia [ALL]).

24 Aug 2007