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Scientists describe novel conjugates made from antibodies and protein inhibitor

Linking therapeutically active molecules to specific antibodies can help to pilot them to their designated targets and minimize side effects--especially when treating tumors. In the journal Angewandte Chemie, scientists have now described novel conjugates made from antibodies and a kinesin spindle protein inhibitor.

31 Oct 2018

Researchers solve protein puzzle that paves way for new cancer therapies

Researchers at Oregon State University have solved a longstanding puzzle concerning the design of molecular motors, paving the way toward new cancer therapies.

13 Jul 2018

U-M research reveals important clues about invasion of polyomaviruses

Every cell in our body runs like a tiny factory that makes specialized products, using the carefully guarded instructions kept in the CEO's office.

24 May 2017

Scientists discover how motors maneuver cells' intricate roadway system

Much like motors power our cars, they also ensure that proteins get to the right place in our cells, and a wide variety of diseases - from cancer to heart problems - can result when they don't.

7 Dec 2016

Researchers discover new therapeutic target for controlling fatal allergic reactions

Researchers in France have identified a molecular motor that controls the release of inflammatory factors that cause severe and fatal allergic reactions.

24 Oct 2016

Solid-state NMR in structural biology: an interview with Professor Tatyana Polenova

My research lab studies several classes of systems. We are mostly interested in looking at large protein assemblies to understand their structure, dynamics and how their properties relate to their malfunction in disease.

From Bruker BioSpin - NMR, EPR and Imaging 21 Sep 2016

RIKEN researchers discover how to reverse abnormal axonal development

Researchers at the RIKEN Brain Science Institute in Japan have discovered how to reverse the abnormal axonal development characteristic of CFEOM3, a congenital disease that affects the muscles that control eye movements.

19 Jan 2016

Motor proteins can stimulate growth of microtubules

Motor proteins that pause at the ends of microtubules and produce pushing forces can also stimulate their growth, according to researchers at Penn State. The proteins' function could be a critical component in understanding cell division and nerve branching and growth.

27 Oct 2015

Researchers identify protein that regulates neuron growth

An international team of researchers, led by scientists at the National University of Singapore (NUS), has identified a protein that regulates the growth of neurons by transporting key metabolic enzymes to the tips of neural cells.

18 Sep 2015

Sandia researchers develop nerve-like polymer network using biological mechanisms

Using a succession of biological mechanisms, Sandia National Laboratories researchers have created linkages of polymer nanotubes that resemble the structure of a nerve, with many out-thrust filaments poised to gather or send electrical impulses.

25 Aug 2015

Scientists reveal complex role of soy in preventing and advancing breast cancer

Scientists have mapped the human genes triggered by the phytonutrients in soy, revealing the complex role the legume plays in both preventing and advancing breast cancer.

29 Apr 2015

Mitochondrial DNA movement: an interview with Professor Jiri Neuzil, Griffith University

According to our understanding, mitochondria undergo cycles of fusion-fission, i.e. they divide within the constraints of a cell and, upon cell division, each of the two daughter cells gets its ‘share’ of mitochondria.

29 Mar 2015

Scientists identify new therapeutic targets, screening test to uncover compounds for memory disorders

In a pair of related studies, scientists from the Florida campus of The Scripps Research Institute have identified a number of new therapeutic targets for memory disorders and have developed a new screening test to uncover compounds that may one day work against those disorders.

12 Nov 2014

Analysis of key cellular protein demonstrates the effectiveness of Taxol anti-cancer drug

A pathway to the design of even more effective versions of the powerful anti-cancer drug Taxol has been opened with the most detailed look ever at the assembly and disassembly of microtubules, tiny fibers of tubulin protein that form the cytoskeletons of living cells and play a crucial role in mitosis.

23 May 2014

Research opens new possibilities for blocking runaway cell division in cancer

The structure of a key part of the machinery that allows cells to divide has been identified by researchers at the University of California, Davis -- opening new possibilities for throwing a wrench in the machine and blocking runaway cell division in cancer.

9 Apr 2014

Study to understand how protein motor works for development of targeted cancer therapies

Researchers at Warwick Medical School have shown for the first time how a protein motor, Kif15, uses acrobatic flexibility to navigate within the mitotic spindle. Understanding how it works could prove vital for the development of targeted cancer therapies.

27 Mar 2014

TSRI receives $2.3M to study long-term memory deficits that contribute to brain diseases

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded approximately $2.3 million from the National Institute of Mental Health to study the processes involved in long-term memory and how deficits in those processes contribute to brain diseases.

14 Feb 2014

Protein presenilin plays critical role in controlling neuronal traffic on microtubule highways

Imagine if you could open up your brain and look inside. What you would see is a network of nerve cells called neurons, each with its own internal highway system for transporting essential materials between different parts of the cell.

29 May 2013

Novel strategy for characterizing RNAs transported from nerve cell to synapse

Despite decades of research, relatively little is known about the identity of RNA molecules that are transported as part of the molecular process underpinning learning and memory.

26 Apr 2013

New details about molecular surveillance system that helps detect and correct errors in cell division

Studies led by cell biologist Thomas Maresca at the University of Massachusetts Amherst are revealing new details about a molecular surveillance system that helps detect and correct errors in cell division that can lead to cell death or human diseases. Findings are reported in the current issue of the Journal of Cell Biology.

21 Jan 2013