Knockout News and Research

RSS

Platelets play a role in mediating the rejuvenating effects of exercise during physiological brain ageing

The impacts of physical activity on the neuronal formation and prevent age-related cognitive decay.

22 Aug 2023

Pig kidney xenotransplantation continues to function well after 32 days

Surgeons at NYU Langone Health have transplanted a genetically engineered pig kidney that continues to function well after 32 days in a man declared dead by neurologic criteria and maintained with a beating heart on ventilator support.

16 Aug 2023

Next-generation sequencing provides novel insights into the mechanisms underlying autism and myotonic muscular dystrophy

The pathomechanistic connection between autism and myotonic muscular dystrophy type 1.

16 Aug 2023

Newly discovered protein kinase shows promise for establishing future obesity and diabetes treatments

Researchers used genetically modified animal models to investigate the role of the newly discovered Traf2- and NCK-interacting protein kinase (TNIK) in obesity and metabolic dysfunction.

15 Aug 2023

Researchers uncover genetic machinery responsible for EBV-induced B cell growth transformation

B cells or B lymphocytes are an important part of the body's immune system. When healthy B cells are infected with the Epstein-Barr virus (EBV), they undergo growth transformation, a process that immortalizes B cells, leading to their uncontrolled proliferation.

7 Aug 2023

Researchers discover how aging can lead to chronic metabolic disorders

Korean researchers have unveiled a novel signaling pathway that fosters aging-related chronic metabolic disorders.

3 Aug 2023

TTUHSC researcher receives $1.76 million grant to investigate new pancreatic cancer treatment

With a survival rate in the single digits, pancreatic ductal adenocarcinoma (PDAC) is highly lethal. In fact, by the time PDAC is clinically diagnosed, it is already considered incurable via surgery or other means in up to 90% of patients.

2 Aug 2023

Cancer-causing gene also plays a crucial role in aging, study finds

A gene called Myc (pronounced "mick") that is among the most important drivers of cancer in both mice and humans also plays a newly discovered crucial role in aging, according to a new Cell Reports study by researchers at UPMC Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine.

24 Jul 2023

Study reveals potential target for repairing beta-cell dysfunction in Type 2 diabetes

Researchers used a murine model to demonstrate that functional excision of murine PITPNA eventually led to hyperglycemia in mice.

19 Jul 2023

Unveiling the key defender: PLSCR1 identified as a potent anti-SARS-CoV-2 factor in COVID-19 immunity

Researchers identified the anti-SARS-CoV-2 function of phospholipid scramblase 1 (PLSCR1).

14 Jul 2023

New mouse model mimics the development of frailty in older adults

Researchers at the Johns Hopkins University School of Medicine have developed a mouse model that successfully mimics the development of frailty as mammals — likely including people — get older.

11 Jul 2023

How B-cells and androgens contribute to the development of PCOS

Researchers evaluate the role of B-cell frequencies in the pathogenesis of polycystic ovary syndrome.

9 Jul 2023

Researchers identify and characterize a key negative regulator of shoot regeneration in Arabidopsis

Plants have the unique ability to regenerate entirely from a somatic cell, i.e., an ordinary cell that does not typically participate in reproduction.

7 Jul 2023

New therapy to mitigate fragile X syndrome may be on the horizon

An antisense therapy developed by Joel D. Richter, PhD, Sneha Shah, PhD, and Jonathan K. Watts, PhD, at UMass Chan Medical School and Elizabeth Berry-Kravis, MD, PhD, at RUSH University Medical Center, restores production of the protein FMRP in cell samples taken from patients with fragile X syndrome.

5 Jul 2023

Researchers uncover the role of glutaminase 2 in glucose homeostasis

Glutaminase 2 (GLS2) is a master regulator of glutaminolysis. GLS2 converts glutamine to glutamate, thereby playing a role in cellular energy production. GLS2 is abundant in the liver, and is also found in pancreatic β-cells. However, the role of GLS2 in pancreatic islets – in which both ɑ- and β- cells are present – associated with glucose metabolism is currently unknown.

5 Jul 2023

Knockout News and Research

Platelets play a role in mediating the rejuvenating effects of exercise during physiological brain ageing

Pig kidney xenotransplantation continues to function well after 32 days

Next-generation sequencing provides novel insights into the mechanisms underlying autism and myotonic muscular dystrophy

Newly discovered protein kinase shows promise for establishing future obesity and diabetes treatments

Researchers uncover genetic machinery responsible for EBV-induced B cell growth transformation

Researchers discover how aging can lead to chronic metabolic disorders

TTUHSC researcher receives $1.76 million grant to investigate new pancreatic cancer treatment

Cancer-causing gene also plays a crucial role in aging, study finds

Study reveals potential target for repairing beta-cell dysfunction in Type 2 diabetes

Unveiling the key defender: PLSCR1 identified as a potent anti-SARS-CoV-2 factor in COVID-19 immunity

New mouse model mimics the development of frailty in older adults

How B-cells and androgens contribute to the development of PCOS

Researchers identify and characterize a key negative regulator of shoot regeneration in Arabidopsis

New therapy to mitigate fragile X syndrome may be on the horizon

Researchers uncover the role of glutaminase 2 in glucose homeostasis

Newly identified enzyme could be a useful tool for creating anticancer drugs

New insights into the mechanisms underlying progression of Huntington's disease

Lipid-degrading enzyme, fatty acid amide hydrolase is a predictor of long-term survival in patients with breast cancer

Study identifies a novel druggable signaling molecule involved in obesity and diabetes

Study shows how IgA acts as a "tuner" to keep the immune system in check

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

Latest News