Knockout Mouse News and Research

RSS

Novel testicular luminal protein is vital for male fertility

Newly produced spermatozoa within the testis are not fully functional until they mature in the epididymis, a duct that helps to transport and store sperm.

9 Jul 2020

Gene expression networks flag potential therapeutic targets for SARS-CoV-2

An international team of researchers from Canada, Australia, the Netherlands, and the United States has identified dozens of genes that could contribute to the pathology of coronavirus disease 2019 (COVID-19) and serve as potential therapeutic targets.

7 Jul 2020

Breakthrough discovery could lead to treatment of Fragile X syndrome

Scientists at the Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, and Owerko Centre at UCalgary's Cumming School of Medicine have made a breakthrough discovery that could lead to treatment of Fragile X syndrome, the leading genetic cause of Autism Spectrum Disorder.

2 Jun 2020

Do ACE inhibitors increase SARS-CoV-2 binding to ACE2?

The COVID-19 pandemic has forced clinicians and academicians to intensive research to find evidence for many conventional therapies. A new round-up editorial published in the journal Cardiovascular Research in April 2020 summarizes the current clinical grounds for and against the use of the commonly used angiotensin axis inhibitors in patients with COVID-19.

20 Apr 2020

Fatty acid-binding protein 4 plays an important role in kidney stone formation

Kidney stone disease has a high prevalence worldwide, ranging up to 13% in North America, 9% in Europe, and 5% in Asia. They are painful for patients, often lead to surgery, and impart a significant economic impact.

23 Mar 2020

Visceral fat gives signal to the brain that damages cognition

Excessive weight around our middle gives our brain's resident immune cells heavy exposure to a signal that turns them against us, setting in motion a crescendo of inflammation that damages cognition, scientists say.

3 Mar 2020

Drug to improve fetal growth may increase blood pressure and blood sugar levels in offspring

Research suggests that a drug recently assessed as a potential treatment for fetal growth restriction may cause high blood pressure and raise blood sugar levels in offspring.

6 Feb 2020

Scientists urge further caution on use of Viagra for fetal therapy

University of Manchester scientists investigating a possible treatment for fetal growth restriction, a condition in which babies grow poorly in the womb, have urged further caution on the use of Viagra.

17 Jan 2020

Improved Cas9 enzyme reduces chance of off-target CRISPR mutations

Genomics experts have discovered that when guide RNAs (gRNA) are designed properly, the risk of off-target mutations induced by the cas9 enzyme is very rare.

30 Oct 2019

Polycomb protein EED plays a complex role in brain development

The dentate gyrus (DG) is the input region of the hippocampus and plays an important role in learning and memory.

13 Jun 2019

Researchers identify hundreds of new genes linked to blindness in lab mice

Hundreds of new genes linked to blindness and other vision disorders have been identified in a screen of mouse strains. Many of these genes are likely important in human vision and the results could help identify new causes of hereditary blindness in patients.

24 Dec 2018

Customizing Genetically Engineered Models for Specific Research Applications

In this interview conducted at SfN 2018, Philip Dubé from Taconic Biosciences, goes into detail about genetically engineered models and their importance in understanding neurodegenerative diseases.

From Taconic Biosciences, Inc. 4 Dec 2018

Dysfunction of single gene leads to miscarriages

A single gene of the mother plays such a crucial role in the development of the placenta that its dysfunction leads to miscarriages.

19 Oct 2018

Study uncovers important role of PRMT1 in dilated cardiomyopathy

In a study published in iScience, Professor Akiyoshi Fukamizu of the Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (University of Tsukuba, JAPAN) and the research group reported a new work on discovery of the important role of PRMT1 in dilated cardiomyopathy.

16 Oct 2018

Nuclear pore complexes are critical for survival of circulating T cells, study shows

Nuclear pore complexes in the nuclear membrane not only control the transport of molecules into and out of the nucleus- they play an essential role in the survival of T cells.

8 May 2018

Researchers move closer to solving puzzle of 15q13.3 microdeletion syndrome

Researchers are closer to solving the puzzle of a complex neurological condition called 15q13.3 microdeletion syndrome. Individuals with this condition are missing a small piece of chromosome 15 that usually contains six genes, but which one of the genes is responsible for the clinical characteristics of patients has not been clear.

2 Feb 2018

Study emphasizes importance of molecule in maintaining balanced immune system in the gut

A healthy gut requires a molecule called gp96 to train the immune system to tolerate food and normal microbes, report researchers at the Medical University of South Carolina in the May 19, 2017 issue of Scientific Reports.

14 Jun 2017

Research shows pNaKtide can attenuate development of NAFLD and atherosclerosis

Building on their recent research focusing on a peptide, pNaKtide, designed to block the oxidant amplifying function of the cellular sodium-potassium pump, researchers at Marshall University Joan C. Edwards School of Medicine have successfully demonstrated that pNaKtide, can attenuate the development of experimental nonalcoholic fatty liver disease (NAFLD) and atherosclerosis.

15 Mar 2017

Novel murine model helps shed light on mechanisms involved in reversible infantile liver failure

Reversible infantile liver failure (RILF) is a heritable mitochondrial condition that causes severe liver dysfunction in infancy, but those who survive the acute stage typically recover and have no further problems.

27 Dec 2016

Researchers identify mutant traits in mouse for many human disease genes

About one-third of all genes in the mammalian genome are essential for life. An international, multi-institutional research collaboration identified, for the first time, mutant traits in the mouse for 52 human disease genes, which significantly contributes to the understanding of the genetic bases for some human diseases, including cardiovascular defects, spina bifida, and metabolic disorders, among many others. The study was published this week in Nature.

19 Sep 2016