Laboratory News and Research

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Machine designed to reduce infections and cut back on expensive "disposables"

Johns Hopkins experts in applied physics, computer engineering, infectious diseases, emergency medicine, microbiology, pathology and surgery have unveiled a 7-foot-tall, $10,000 shower-cubicle-shaped device that automatically sanitizes in 30 minutes all sorts of hard-to-clean equipment in the highly trafficked hospital emergency department.

30 Jul 2009

Covance enters strategic genomic services agreement with Merck

Covance has announced it has entered into a definitive agreement with Merck & Co., Inc. relating to the supply of genomic analysis services.

30 Jul 2009

Protein level may predict severe osteoarthritis

Osteoarthritis (OA), the most common joint disorder throughout the world and a leading cause of disability, is characterized by pain, impaired joint mobility, reduction of muscular strength and loss of joint function. Unlike most other common diseases, little is known about its origins, and factors predicting a severe disease course have not been identified.

30 Jul 2009

No evidence for superior nutritional content of organic produce

There is no evidence that organically produced foods are nutritionally superior to conventionally produced foodstuffs, according to a study published in The American Journal of Clinical Nutrition.

29 Jul 2009

Acute stress improves working memory

Day after day of chronic stress will wear a person down physically and mentally. But new research suggests that the acute stress produced by a brief run-in with a stressful scenario acts on a key brain region controlling emotion and cognition, temporarily improving learning and memory.

28 Jul 2009

Mathematical modeling predicts Herceptin resistance

Cancer researchers are turning to mathematical models to help answer important clinical questions, and a new paper in Cancer Research, a journal of the American Association for Cancer Research, illustrates how the technique may answer questions about Herceptin resistance.

28 Jul 2009

Spermatagonial stem cells can be directly converted into other cell types

Researchers have found a way to directly convert spermatogonial stem cells, the precursors of sperm cells, into tissues of the prostate, skin and uterus. Their approach, described this month in the journal Stem Cells, may prove to be an effective alternative to the medical use of embryonic stem cells.

28 Jul 2009

Study of pulmonary hypertension treatment in sickle cell patients stopped by NHLBI

The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health has stopped a clinical trial testing a drug treatment for pulmonary hypertension in adults with sickle cell disease nearly one year early due to safety concerns.

28 Jul 2009

Anesthesia not harmful for babies during birth process

Mayo Clinic researchers have found that children exposed to anesthesia during Cesarean section are not at any higher risk for learning disabilities later in life than children not delivered by C-section. These findings are reported in the current issue of the journal Anesthesiology.

28 Jul 2009

University at Buffalo start-up provides innovative digital sperm analysis to infertile couples worldwide

Couples struggling with fertility problems have a new option for assessing their ability to have a child with the start-up of a new Buffalo-based company called LifeCell Dx, Inc. (LCDX).

27 Jul 2009

Enzyme implicated in blood flow in Alzheimer’s, disease progression

Researchers have discovered that the enzyme, endothelin converting enzyme-2 (ECE-2), may cause the decrease in blood flow in the brain seen in Alzheimer's disease and contribute to progression of the disease.

27 Jul 2009

Music drives experimental samples through a lab-on-a-chip

Music, rather than electromechanical valves, can drive experimental samples through a lab-on-a-chip in a new system developed at the University of Michigan. This development could significantly simplify the process of conducting experiments in microfluidic devices.

27 Jul 2009

Potential malaria transmission-blocking vaccine

Researchers at the Johns Hopkins Malaria Research Institute have for the first time produced a malarial protein (Pfs48/45) in the proper conformation and quantity to generate a significant immune response in mice and non-human primates for use in a potential transmission-blocking vaccine.

26 Jul 2009

'Urine NGAL' gives clues to kidney injury in ICU patients and HIV-related kidney disease

Acute kidney injury (AKI) is a frequent complication in patients in intensive care. A new laboratory test called urine neutrophil gelatinase associated lipocalin (NGAL) helps predict if patients will develop acute kidney injury, reports an upcoming study in the Journal of the American Society of Nephrology (JASN).

26 Jul 2009

Nanoparticle antimicrobial gel formulation for topical use

Scientists in India are reporting successful laboratory tests of a new and potentially safer alternative to silver-based gels applied to the skin of burn patients to treat infections.

26 Jul 2009

Research builds on previous Par-4 study that produced cancer-resistant mouse

Human cells are able to secrete a cancer-killing protein, scientists at the University of Kentucky's Markey Cancer Center have found.

26 Jul 2009

Bones from stem cell technology

Scientists are closer to understanding how to grow replacement bones with stem cell technology, thanks to research published today in the journal Nature Materials.

26 Jul 2009

Protein produced by gene fusion that may also be targeted for new prostate cancer therapies

Researchers from NewYork-Presbyterian Hospital/Weill Cornell Medical Center have discovered a new gene fusion that is highly expressed in a subset of prostate cancers.

24 Jul 2009

FDA authorizes emergency use of another test for H1N1 flu virus

The U.S. Food and Drug Administration today announced it has issued an Emergency Use Authorization (EUA) for a another diagnostic test for the 2009 H1N1 influenza virus, whose spread has caused the virus to be characterized as a pandemic by the World Health Organization.

24 Jul 2009

Compact gamma camera for prostate cancer imaging

The U.S. Department of Energy's Brookhaven National Laboratory and Hybridyne Imaging Technologies, Inc., of Toronto, Canada, have won a 2009 R&D 100 Award for developing a compact gamma camera for high-resolution imaging of prostate cancer.

23 Jul 2009