Laboratory News and Research

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Novel approach to creating a vaccine to treat melanoma

A novel approach to creating a vaccine to treat melanoma has demonstrated promising effectiveness in a new laboratory study led by researchers at The Wistar Institute. About a third of melanoma patients might benefit from such a vaccine.

4 Apr 2006

Researchers reverse juvenile diabetes in animal model

Groundbreaking human clinical trial for type 1 diabetes to start this spring in Pittsburgh - Children's Hospital of Pittsburgh of UPMC researchers reverse juvenile diabetes in animal model; Phase 1 clinical trial approved by FDA.

4 Apr 2006

Breakthrough in search for new anti-malarial drugs

Scientists at Drexel University College of Medicine in Philadelphia have made a significant discovery in the fight against malaria. Drexel researchers, along with a research group at the University of Washington, have determined a critical molecular structure of the cellular motor that allows the malaria parasite to invade human cells.

4 Apr 2006

Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis

The unchecked activity of a cell signaling pathway crucial in embryonic development and the liver's response to injury leads to liver cancer, researchers from Duke University Medical Center and John Hopkins University School of Medicine have found.

4 Apr 2006

Robotic device appears to be more precise than conventional catheter ablation devices for atrial fibrillation

A remotely-controlled catheter device guided by magnetic fields provides a safe and practical method for delivering radio frequency ablation treatment in the hearts of patients with atrial fibrillation, according to a new study in the April 4, 2006, issue of the Journal of the American College of Cardiology.

4 Apr 2006

Skin cancer facts

Up to two-thirds of all cancers may be prevented through dietary and lifestyle changes. In the case of skin cancer, this could not be more true.

4 Apr 2006

HOXB13 and IL17BR genes predict outcome for breast cancer patients

The 2-gene expression profile of HOXB13 and IL17BR in a woman's breast cancer predicts risk of recurrence in node-negative patients treated with tamoxifen.

4 Apr 2006

Enzymes that harm brain immediately after stroke may be beneficial days later

Insights from the study could change the way stroke is treated, extending the window for effective treatment from a couple of hours to a couple of weeks. The results may suggest new ideas for drug development.

4 Apr 2006

Link between lead and osteoporosis strengthens

Bolstered by recent laboratory findings, researchers at the University of Rochester Medical Center are embarking on a National Institutes of Health-funded clinical study to better understand the deceptive role environmental lead exposure plays in bone maturation and loss.

4 Apr 2006

Responding to AIDS, TB, Malaria and emerging infectious diseases in Burma

Government policies in Burma that restrict public health and humanitarian aid have created an environment where AIDS, drug-resistant tuberculosis, malaria and bird flu (H5N1) are spreading unchecked, according to a report by researchers at the Johns Hopkins Bloomberg School of Public Health.

4 Apr 2006

Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis

Inflammation, cartilage and bone erosions, joint destruction--that's the typical progression of arthritis and most rheumatic diseases.

4 Apr 2006

Transportation of prion protein across the intestinal mucosa of scrapie-susceptible and scrapie-resistant sheep

While newly published research confirms that under laboratory circumstances prion-protein can be absorbed across the gut, it also shows that this is unlikely to occur in real life.

4 Apr 2006

Natural killer cells and antibody-based immune function

A new drug may boost the effectiveness of a widely used treatment for patients with non-Hodgkin lymphoma (NHL), while simultaneously overcoming drug resistance in those patients.

4 Apr 2006

Link between children's sleep-related breathing problems and daytime behavior problems

Hyperactivity, attention deficit, sleepiness, and ADHD often improved - whether or not sleep studies showed sleep apnea before surgery.

4 Apr 2006

Omega-3 fatty acids inhibit the growth of liver cancer cells

Two new studies by a University of Pittsburgh research team suggest that omega-3 fatty acids - substances that are found in high concentrations in fish oils and certain seeds and nuts - significantly inhibit the growth of liver cancer cells.

3 Apr 2006

New device could cut chemotherapy deaths

A new method of delivering chemotherapy to cancer patients without incurring side effects such as hair loss and vomiting is being developed.

31 Mar 2006

Serum tumor markers predict extravesical disease in clinical stage T2 bladder cancer

Bladder cancer clinical staging is notoriously poor in patients with muscle invasive disease.

31 Mar 2006

New evidence questions the simple link between prion proteins and vCJD

While newly published research confirms that under laboratory circumstances prion-protein can be absorbed across the gut, it also shows that this is unlikely to occur in real life.

30 Mar 2006

Minimal genome should be twice the size

The simplest bacteria need almost twice as many genes to survive than scientists first believed, according to new research published in Nature (30 March 2006).

30 Mar 2006

Weill Cornell researchers identify tumor-suppressor gene important to diffuse large B-cell lymphomas

Inactivation of a "tumor suppressor" gene could be a major cause of a class of blood cancers called diffuse large B-cell lymphomas, reports a team of researchers at the Weill Medical College of Cornell University.

30 Mar 2006