Laboratory News and Research

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Little evidence exists to support the widespread use of bronchodilators to treat children and adults with cystic fibrosis

"Recurrent wheeze and breathlessness are common in people with cystic fibrosis, and bronchodilators are commonly prescribed," according to lead author Clare Halfhide, M.D., of the Royal Liverpool Children's Hospital in England. "Despite their wide-scale and often long-term use, there is limited objective evidence about their efficacy in cystic fibrosis."

25 Oct 2005

Gene therapy used to successfully treat heart failure

University of Pittsburgh investigators have for the first time used gene therapy to successfully treat heart failure and other degenerative muscle problems in an animal model that is genetically susceptible to a human muscular dystrophy.

25 Oct 2005

New technique reveals the strength of bones

Scientists have developed a technique which can be used to reveal the strength of bones, allowing doctors to more accurately estimate the risk of bone fracture.

25 Oct 2005

Identification of gene in mosquitoes that helps them to fight off infection by the Plasmodium parasite

Researchers have identified a gene in mosquitoes that helps the insects to fight off infection by the Plasmodium parasite, which causes malaria in humans. Anopheles mosquitoes transmit the malaria parasite to nearly 550 million people worldwide each year with these cases resulting in more than 2 million deaths annually.

25 Oct 2005

Scientists gain better understanding of how repetitive stretching of endothelial cells that line arteries can make them healthy and resistant to vascular diseases

UCSD researchers stretched cells in a workout chamber the size of a credit card to gain a better understanding of how repetitive stretching of endothelial cells that line arteries can make them healthy and resistant to vascular diseases.

24 Oct 2005

St. John's wort plant has the capacity to inhibit expression of the HIV-1 gene

A novel protein, p27SJ, extracted from a callus culture of the St. John's wort plant (Hypericum perforatum) suppresses HIV-1 expression and inhibits its replication, according to researchers at Temple University School of Medicine's department of neuroscience and Center for Neurovirology (CNV).

24 Oct 2005

Blocking a signaling lipid can keep nerves from developing and may even cause neurons to die

Blocking a signaling lipid can keep nerves from developing the arm-like extensions they need to wire the body and may even cause neurons to die, researchers have found.

24 Oct 2005

Mixed carbon nanotubes and standard urban particulates suggests a risk of thrombosis from airborne pollution

Carbon nanoparticles - both those unleashed in the air by engine exhaust and the engineered structures thought to have great potential in medical applications - promote blood-clotting, scientists report in an upcoming edition of the British Journal of Pharmacology.

23 Oct 2005

Gene found only in men is altered by a chemical process, which is in turn linked to aggressive forms of melanoma

New scientific evidence that may shed light on why men are more likely than women to develop aggressive forms of skin cancer has been published in Carcinogenesis.

23 Oct 2005

Researchers learn to rapidly rebuild immunity in immune-suppressed cancer patients

Patients with multiple myeloma suffer from a malignant proliferation of plasma cells in their bone marrow. The standard treatment for this form of cancer is high-dose chemotherapy and transplantation of one's own blood-producing adult stem cells; however, this aggressive treatment wipes out the mature immune-system cells of patients – leaving them vulnerable to infection.

20 Oct 2005

Discovery of a new kind of messenger RNA molecule

Researchers at Cold Spring Harbor Laboratory have discovered a new kind of messenger RNA molecule that is converted from non-protein coding status to protein coding status in response to cellular stress such as viral infection.

20 Oct 2005

Spliceosome crucial for processing non-coding RNA

The discovery in 1977 that the coding regions of a gene could appear in separate segments along the DNA won the 1993 Nobel Prize in Physiology or Medicine for Richard J. Roberts and Phillip A. Sharp. The active segments of a gene were termed exons, separated from each other within the gene by inactive introns.

20 Oct 2005

Molecule P-glycoprotein (Pgp), may help reduce risk of Alzheimer's

A molecule that has long been an obstacle to cancer chemotherapy and drug treatments for brain disorders may soon become an ally in the fight against Alzheimer's disease, according to researchers at Washington University School of Medicine in St. Louis and the University of Rochester.

20 Oct 2005

Neurobiologists gain new insights into brain and memory

We often make unwise choices although we should know better. Thunderstorm clouds ominously darken the horizon. We nonetheless go out without an umbrella because we are distracted and forget. But do we?

19 Oct 2005

Identification of a single chromosome region linked to specific language impairment

Researchers at the University of Toronto (U of T), Capital Health's Stollery Children's Hospital in Edmonton, Toronto's Hospital for Sick Children and their international collaborators have discovered a genetic abnormality that causes a type of language impairment in children

19 Oct 2005

Controlling antibiotic-prescribing practices in hospitals

Plenty of promising strategies exist to control antibiotic-prescribing practices, but no single method emerges as the best for hospital patients, according to a new review of studies.

18 Oct 2005

Aβ and Fyn cooperate to cause Alzheimer-like changes in the brain

Reporting in two companion papers in the October 19 issue of the Journal of Neuroscience, investigators from the Gladstone Institute of Neurological Disease show in genetically engineered mouse models of the disease that the accumulation of Alzheimer-related neurotoxic amyloid-beta (Aâ) peptides can deplete key proteins in a specific memory center of the brain.

18 Oct 2005

Study demonstrates feasibility of a revolutionary, minimally invasive approach to introducing an electrical lead to stimulate the heart

Correcting the timing of heart contractions through cardiac resynchronization therapy can be a lifesaver for people with advanced heart failure. But the procedure, as it is done today, fails in about 15 percent of patients.

18 Oct 2005

Cutting-edge research to develop this range of next-generation biomedical devices

Revolutionary new self-diagnostic devices to provide early warning of deadly and debilitating illnesses like cancer, diabetes and heart disease are the aim of a Euro 22.5m Science Foundation Ireland research facility to be established at Dublin City University.

18 Oct 2005

Discovery increases the yield of stem cells from umbilical cord blood

A team of bioengineers led by the University of Toronto has discovered a way to increase the yield of stem cells from umbilical cord blood, to an extent which could broaden therapeutic use of these cells.

18 Oct 2005

Laboratory News and Research

Little evidence exists to support the widespread use of bronchodilators to treat children and adults with cystic fibrosis

Gene therapy used to successfully treat heart failure

New technique reveals the strength of bones

Identification of gene in mosquitoes that helps them to fight off infection by the Plasmodium parasite

Scientists gain better understanding of how repetitive stretching of endothelial cells that line arteries can make them healthy and resistant to vascular diseases

St. John's wort plant has the capacity to inhibit expression of the HIV-1 gene

Blocking a signaling lipid can keep nerves from developing and may even cause neurons to die

Mixed carbon nanotubes and standard urban particulates suggests a risk of thrombosis from airborne pollution

Gene found only in men is altered by a chemical process, which is in turn linked to aggressive forms of melanoma

Researchers learn to rapidly rebuild immunity in immune-suppressed cancer patients

Discovery of a new kind of messenger RNA molecule

Spliceosome crucial for processing non-coding RNA

Molecule P-glycoprotein (Pgp), may help reduce risk of Alzheimer's

Neurobiologists gain new insights into brain and memory

Identification of a single chromosome region linked to specific language impairment

Controlling antibiotic-prescribing practices in hospitals

Aβ and Fyn cooperate to cause Alzheimer-like changes in the brain

Study demonstrates feasibility of a revolutionary, minimally invasive approach to introducing an electrical lead to stimulate the heart

Cutting-edge research to develop this range of next-generation biomedical devices

Discovery increases the yield of stem cells from umbilical cord blood

Lab Diagnostics and Automation - Second Edition eBook

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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