Leishmaniasis News and Research

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Leishmaniasis is a parasitic disease transmitted by the bite of infected sand flies. It is found in nearly 88 countries, from rain forests in Central and South America to deserts in the Middle East and west Asia. Some cases of the disease have also appeared in Mexico and Texas.

Leishmaniasis takes several different forms, including the most common cutaneous leishmaniasis, which causes skin sores, and the more severe visceral leishmaniasis, which affects internal organs such as the spleen, liver, and bone marrow. The World Health Organization (WHO) estimates that there are 1.5 million new cases of cutaneous leishmaniasis and 500,000 new cases of visceral leishmaniasis in the world each year.

Gene playing crucial role in immune system balance identified

A team led by St. Jude researchers identified a gene pivotal for immune system balance. Ultimately, the discovery may aid efforts to tame allergies and asthma.

12 Apr 2010

DNA barcoding-sequencing of gene in sand flies identifies two species carrying Leishmania naiffi

In the first survey of sand flies in Panama to use genetic barcoding, scientists at the Smithsonian Tropical Research Institute and Gorgas Memorial Laboratories identified 20 sand fly species from Barro Colorado Island. Two species carried Leishmania naiffi, a parasite that causes cutaneous leishmaniasis: persistent, itchy skin lesions. Three species carried Wolbachia, a bacterial parasite of insects that could contribute to a strategy to control the flies and limit disease transmission.

7 Apr 2010

Scientists identify potential new method for treating sleeping sickness

Scientists have identified a potential new approach to treat human African trypanosomiasis (HAT), commonly known as sleeping sickness, which afflicts "tens of thousands of people in sub-Saharan Africa" annually, IRIN reports. By targeting an enzyme the sleeping sickness parasite needs in order to survive, researchers say they can kill it without causing harm to the patient (4/1).

2 Apr 2010

VA may expand list of Gulf War illnesses

The Army Times/Veterans Today: "In a boost for veterans of the 1991 Persian Gulf War and those who have served in recent years in Iraq and Afghanistan, the Veterans Affairs Department has proposed changes to its list of illnesses that are presumed connected to service to include nine infectious diseases."

1 Apr 2010

Major breakthrough may help develop low toxicity drugs for sleeping sickness

Scientists from the Drug Discovery Unit at the University of Dundee - working together with partners at the University of York and the Structural Genomics Consortium in Toronto - have made a major breakthrough in identifying new treatments for a fatal disease which infects tens of thousands of Africans each year.

1 Apr 2010

SRI International researchers to disclose preliminary results of NTD detecting diagnostic at 239th ACS

SRI International, an independent nonprofit research and development organization, will present preliminary results of a diagnostic to detect neglected tropical diseases (NTDs) at the 239th National Meeting & Exhibition of the American Chemical Society (ACS) being held on March 21-25 in San Francisco.

22 Mar 2010

'Dipstick' 3-in-1 test for detection of Chagas' disease, leishmaniasis and African trypanosomiasis

A new simple, inexpensive three-in-one test to diagnose a terrible trio of parasitic diseases that wreak havoc in the developing world is passing preliminary tests, scientists reported here today. Described during the 239th National Meeting of the American Chemical Society the test is for Chagas' disease, leishmaniasis, and "sleeping sickness" or African trypanosomiasis.

22 Mar 2010

Research suggests anti-cancer drugs can help treat infectious diseases

Drugs increasingly used to treat cancer could have a major impact on a wide range of infectious diseases, according to new research.

16 Mar 2010

International symposium to feature latest findings on vector-borne diseases in humans and plants

Leading insect vector biologists from around the world will gather at the University of California, Riverside for two days this month to discuss their latest research on vector-borne diseases in humans and plants.

16 Mar 2010

Heat therapy using Thermomed device effective for treatment of leishmaniasis

A single session of heat therapy using the Thermomed™ device appears to be as effective as a 10-day intravenous course of sodium stibogluconate (Pentostam) for the treatment of Leishmania major skin lesions, according to a new study by Naomi Aronson and her colleagues at the Uniformed Services University of the Health Sciences and Walter Reed Army Medical Center.

9 Mar 2010

Scientists find single-dose of drug cures visceral leishmaniasis

A study has shown that a single infusion of Gilead Sciences' drug AmBisome, known generically as iposomal amphotericin B, cured nearly all patients with visceral leishmaniasis, or kala-azar, a parasitic infection, Reuters reports.

12 Feb 2010

Global health community to be engaged in using resources of GSK and Alnylam IP Pool

BIO Ventures for Global Health, GlaxoSmithKline (GSK), and Alnylam announced today that the organizations are partnering to engage the global health community in using the powerful resources of the GSK and Alnylam Intellectual Property (IP) Pool.

21 Jan 2010

Scientists determine structure of enzyme essential to the survival of protozoan parasites

After many years of study, a team of researchers is releasing data today that it hopes will lead to new drug therapies that will kill the family of parasites that causes a deadly trio of insect-borne diseases and has afflicted inhabitants of underdeveloped and developing nations for centuries.

18 Jan 2010

IRIN series examines health, development issues in Kenya

In a special series, IRIN examines health and development in Kenya. "The vast arid lands of northern Kenya are generally drier, less fertile, poorer and rank lower in most humanitarian and development league tables than the rest of the country. ... Preventable and treatable diseases are often neither prevented nor treated for want of adequate healthcare. Attracting qualified doctors and nurses to the hinterland is a major challenge.

24 Dec 2009

MSF report names malnutrition, inadequate funds for HIV/AIDS, neglected diseases among top humanitarian crises of 2009

Inadequate international funding for HIV/AIDS and neglected diseases as well as global malnutrition were among the top 10 humanitarian crises outlined in an annual report issued Monday by Medecins Sans Frontieres, the Associated Press reports (Astor, 12/21).

22 Dec 2009

Bill & Melinda Gates Foundation grants funds for visceral leishmaniasis research

The Hebrew University of Jerusalem Kuvin Center for the Study of Infectious and Tropical Diseases has received a $5 million grant from the Bill & Melinda Gates Foundation for research into visceral leishmaniasis.

18 Dec 2009

Hebrew University of Jerusalem receives $5 million grant from Bill & Melinda Gates Foundation

17 Dec 2009

Hebrew University of Jerusalem granted $5M for research into visceral leishmaniasis in Ethiopia

17 Dec 2009

Researchers to receive more than $4.5 million in grants to study Sudden Infant Death Syndrome

Researchers at the Los Angeles Biomedical Research Institute (LA BioMed) expect to receive more than $4.5 million in grants from the American Recovery and Reinvestment Act (Recovery Act.), including nearly $1 million from the highly competitive Challenge Grant program for a study that seeks to reduce the number of children who die from Sudden Infant Death Syndrome, it was announced today.

15 Dec 2009

Second-quarter fiscal 2010 results announced by Peregrine Pharmaceuticals

Peregrine Pharmaceuticals, Inc. today announced financial results for the second quarter of fiscal year (FY) 2010 ended October 31, 2009. Total revenue for the second quarter of FY 2010 increased 255% to $6,896,000, compared to $1,941,000 for the comparable prior year quarter.

10 Dec 2009