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Research illuminates how primary colorectal tumors contribute to premetastatic 'niche' formation

Primary colorectal tumors secrete VEGF-A, inducing CXCL1 and CXCR2-positive myeloid-derived suppressor cell (MDSC) recruitment at distant sites and establishing niches for future metastases, report Medical University of South Carolina investigators in an article published online ahead of print on April 28, 2017 by Cancer Research.

10 May 2017

Combination of anti-angiogenic and immune-stimulating therapies can lead to effective cancer treatments

Scientists from VIB and KU Leuven, together with colleagues from the University of California and the Swiss Institute for Experimental Cancer Research have demonstrated that, anti-angiogenic therapy can improve immune boosting treatments.

13 Apr 2017

New finding on key protein opens door to potential therapies for chronic illnesses

Scientists have determined unexpected characteristics of a key protein linked to blood pressure control and to nerve growth, pain control and heart tissue regeneration. The findings, published April 5 online in the journal Nature, opens doors to potential new therapies to control cardiovascular disease and pain.

6 Apr 2017

Study explores new immunotherapy combinations to treat prostate cancer

Prostate cancer, notoriously resistant to immunotherapy due to its immunologically cool nature, triggers two pathways to chill an immune attack after one immunotherapy drug fires up the immune system, researchers at The University of Texas MD Anderson Cancer Center report in Nature Medicine.

29 Mar 2017

SLU researchers aim to tackle diabetes and obesity by capturing benefits of exercise in pill form

With a series of new grants, Saint Louis University researchers will tackle the twin epidemics of diabetes and obesity by tapping into the potential of two nuclear receptors that control muscle metabolism.

24 Mar 2017

Scientists identify molecule that could be targeted to prevent vision loss in diabetics and preterm infants

Researchers at Bascom Palmer Eye Institute, part of the University of Miami Miller School of Medicine, have identified a new molecule that induces the formation of abnormal blood vessels in the eyes of diabetic mice.

23 Mar 2017

MIT researchers devise new strategy to make tumor cells more susceptible to cancer treatment

MIT researchers have devised a way to make tumor cells more susceptible to certain types of cancer treatment by coating the cells with nanoparticles before delivering drugs.

20 Mar 2017

New biomarker 'Bim' could help predict optimal treatment for metastatic melanoma patients

Over the past few years, checkpoint blockade immunotherapies have revolutionized cancer treatment and helped many patients who were previously considered untreatable.

8 Mar 2017

Researchers to examine link between zinc deficiency, Hedgehog, and prostate cancer

Experiments show that Hedgehog signaling - a chain of molecular events critical in embryonic development - creates conditions beneficial to the unregulated cell growth associated with cancer in adults.

28 Feb 2017

Huddersfield researchers discover cancer curing molecule that opens door for highly-effective treatment

SCIENTISTS at the University of Huddersfield are the first to arrive at a deep understanding of a molecule that destroys cancerous tumours without harming healthy cell tissue.

27 Feb 2017

Researchers reveal biological pathways involved in diabetic kidney disease

Diabetes is a leading cause of kidney disease, a serious, often fatal complication that is difficult to diagnose in early, potentially treatable stages.

24 Feb 2017

Melanoma patients' immunotherapy response linked to diversity and makeup of gut bacteria

Melanoma patients' response to a major form of immunotherapy is associated with the diversity and makeup of trillions of potential allies and enemies found in the digestive tract, researchers at The University of Texas MD Anderson Cancer Center report at the ASCO-Society for Immunotherapy in Cancer meeting in Orlando.

22 Feb 2017

Researchers find novel, non-invasive approach for diagnosis and prognosis of prostate cancer

In a new paper in Springer's Journal of Materials Science, researchers at Washington State University report a new approach for the effective capture of tumor-derived exosomes from a prostate cancer cell line.

21 Feb 2017

EPFL scientists develop new computer model for better design of allosteric drugs

EPFL scientists have created a new computer model that can help better design of allosteric drugs, which control proteins "at a distance".

21 Feb 2017

Targeting RNA repeats

RNA repeats are stretches of code in the body that incrementally repeat. For example, in the most common cause of adult-on-set muscular dystrophy a RNA has a repeat of r(CUG) and this three letter code can repeat thousands of times.

20 Feb 2017

New approach could make organometallic catalysis applicable for therapy or diagnostics

A gold catalyst can be delivered to a target organ in a higher organism where it performs a chemical transformation visualized by bioimaging.

17 Feb 2017

Researchers explore role played by nicotine in grouping of nicotinic receptors within the brain

Nicotine -- the primary compound found within tobacco smoke -- is known to change the grouping of some subtypes of nicotinic receptors, but the mechanisms for nicotine addiction remain unclear.

15 Feb 2017

Researchers develop new iron oxide nanoparticles as contrast agent for MRI

A new, specially coated iron oxide nanoparticle developed by a team at MIT and elsewhere could provide an alternative to conventional gadolinium-based contrast agents used for magnetic resonance imaging procedures.

14 Feb 2017

Testing treatments for bone cancer may get easier with enhanced 3D-printed scaffolds

Testing treatments for bone cancer tumors may get easier with new enhancements to sophisticated support structures that mimic their biological environment, according to Rice University scientists.

9 Feb 2017

Scientists identify structure of androgenic receptor essential to fight against prostate cancer

A team led by researchers of the Institute of Biomedicine of the University of Barcelona and the Research Institute of the Hospital de la Santa Creu i Sant Paushows for the first time, the three-dimensional structure of the homodimeric androgen receptor ligand-binding domain, a structure that eluded researchers for years.

6 Feb 2017