Ligand News and Research

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Identification of plasma proteins associated with ovarian cancer risk

Researchers performed proteomic Mendelian randomization as well as co-localization analyses to identify drug targets for ovarian cancer.

8 Aug 2023

Molecular insights: Detecting gene fusions offers new avenues for advanced cancer management

Study identifies gene fusions to understand their relationship with observed pathologies in cancer patients.

8 Aug 2023

Study reports the first protein-based diagnostic signature to discriminate MIS-C from Kawasaki Disease and other common infections

Researchers explore the distinguishing features of MIS-C as compared to other inflammatory-infectious syndromes in children.

4 Aug 2023

Multifunctional Ga-based nanoparticles combine cancer phototherapy with immunotherapy

Researchers develop a novel cancer theranostic agent that can covert light energy to heat and in turn destroy cancer cells

4 Aug 2023

Nutrition meets cancer therapy: How gut microbiome and diet impact immunotherapy success

Researchers investigated the complex relationship between gut bacteria, diet, and patient nutrition.

4 Aug 2023

Researchers discover new spiroindolin-1,2-diazepine derivatives with anti-Alzheimer therapeutic potential

In a recent study, researchers designed substituted spiro indolin-1,2-diazepine derivatives '5a–v' with cholinesterase inhibitory activities as anti-Alzheimer's disease agents.

31 Jul 2023

New technique revolutionizes protein-ligand interaction studies

Raman spectroscopy -; a chemical analysis method that shines monochromatic light onto a sample and records the scattered light that emerges -; has caused frustration among biomedical researchers for more than half a century.

28 Jul 2023

Cryo-EM study elucidates 3D structure and molecular mechanism of platelet drug transporter

A research team led by Prof. CHEN Yuxing and Prof. ZHOU Cong from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) recently utilized single-particle cryogenic electron microscopy (cryo-EM) to decipher the 3D structure and molecular mechanism of the platelet drug transporter ABCC4.

28 Jul 2023

Scientists map 3D structure of kappa opioid receptor

Opioids remain the most potent and effective pain relievers in medicine, but they're also among the most addictive drugs that can halt a person's ability to breathe during an overdose -; which can be deadly.

27 Jul 2023

MD Anderson and Nexo Therapeutics partner to advance new cancer therapies against previously undruggable targets

The University of Texas MD Anderson Cancer Center and Nexo Therapeutics today announced a multi-year strategic collaboration that aligns the innovative technology and capabilities of each organization at the earliest stages of drug discovery and development to rapidly advance impactful new cancer therapies against previously undruggable targets.

26 Jul 2023

Tumor-derived GDF-15 suppresses immunotherapy response

Researchers evaluate the impact of tumor-derived GDF-15 on responses to anti-PD-1 immunotherapy.

26 Jul 2023

Arrayjet announces collaboration with Chemspace to augment its small molecule microarray services for drug discovery

Arrayjet, a leading provider of inkjet liquid-handling solutions, today announced that it has partnered with Chemspace, the largest online catalogue of small molecules and biologics, to augment and streamline the Company’s small molecule microarray (SMM) service offering.

From Arrayjet Ltd 19 Jul 2023

Immunodiagnosis: Unleashing the potential of personalized immunotherapy

Researchers discuss the concept of immunodiagnosis and explores the potential of artificial intelligence in ID systems for precise tumor immunotherapy.

18 Jul 2023

BUB1 protein and its kinase activity may regulate EGFR activation

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 13, entitled, "Budding uninhibited by benzimidazoles-1 (BUB1) regulates EGFR signaling by reducing EGFR internalization."

18 Jul 2023

New insights into dendritic cell biology could lead to improved cancer therapies

The cells of the immune system circulate mainly in the blood and migrate into the body's tissues after an inflammation. Some types of immune cells, however, are permanently located in the tissues, where they come together to form three-dimensional networks.

17 Jul 2023

Investigating the role of T-cell immunity in long COVID

Researchers investigates the persistence of symptoms and the immune response in patients recovering from COVID-19.

13 Jul 2023

Researchers find new way to target leprosy infection

Leprosy has existed since at least Biblical times, yet scientists still don't know exactly how Mycobacterium leprae causes the disease's symptoms.

12 Jul 2023

How does SARS-CoV-2 affect the placenta during pregnancy?

Researchers examine host responses to SARS-CoV-2 within the placenta using transcriptomics.

12 Jul 2023

The genetics of neurogenic inflammation in rosacea

Researchers identify rare genetic variants in families with rosacea.

11 Jul 2023

Australian rainforest remedies: Scientists explore bioactive plant compounds as potential anti-neuroinflammatory agents

Research discusses the process of discovering anti-inflammatory and neuroprotective drugs from medicinal plants found in the Australian rainforest. It focuses on the pathways from the discovery of bioactive plants to the validation in an appropriate neuro-inflammatory mouse model, using some examples from their current research.

9 Jul 2023

Ligand News and Research

Identification of plasma proteins associated with ovarian cancer risk

Molecular insights: Detecting gene fusions offers new avenues for advanced cancer management

Study reports the first protein-based diagnostic signature to discriminate MIS-C from Kawasaki Disease and other common infections

Multifunctional Ga-based nanoparticles combine cancer phototherapy with immunotherapy

Nutrition meets cancer therapy: How gut microbiome and diet impact immunotherapy success

Researchers discover new spiroindolin-1,2-diazepine derivatives with anti-Alzheimer therapeutic potential

New technique revolutionizes protein-ligand interaction studies

Cryo-EM study elucidates 3D structure and molecular mechanism of platelet drug transporter

Scientists map 3D structure of kappa opioid receptor

MD Anderson and Nexo Therapeutics partner to advance new cancer therapies against previously undruggable targets

Tumor-derived GDF-15 suppresses immunotherapy response

Arrayjet announces collaboration with Chemspace to augment its small molecule microarray services for drug discovery

Immunodiagnosis: Unleashing the potential of personalized immunotherapy

BUB1 protein and its kinase activity may regulate EGFR activation

New insights into dendritic cell biology could lead to improved cancer therapies

Investigating the role of T-cell immunity in long COVID

Researchers find new way to target leprosy infection

How does SARS-CoV-2 affect the placenta during pregnancy?

The genetics of neurogenic inflammation in rosacea

Australian rainforest remedies: Scientists explore bioactive plant compounds as potential anti-neuroinflammatory agents

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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