Lipase News and Research

RSS

Amsterdam Molecular Therapeutics commences preregistration trial for Glybera

Amsterdam Molecular Therapeutics announced today the treatment of the first patient in a preregistration clinical trial with Glybera. This gene therapy product targets lipoprotein lipase deficiency (LPLD), a seriously debilitating and potentially lethal disease.

7 May 2009

Genetic links to high levels of HDL cholesterol

HDL cholesterol (HDL-C), or "good" cholesterol, carries excess cholesterol - that might otherwise block arteries - from blood vessels back to the liver for processing and elimination.

16 Mar 2009

C. elegans worms may hold key to new treatments for obesity in humans

A previously unknown mutation discovered in a common roundworm holds the promise of new treatments for obesity in humans, McGill University researchers say.

8 Dec 2008

Altus Pharmaceuticals reaffirms plan to submit NDA for Trizytek

Altus Pharmaceuticals Inc. announced today that it is reaffirming its plan to submit a new drug application (NDA) for Trizytek TM (liprotamase) in the first-half of 2009.

18 Nov 2008

Microbial population of raw milk found to be more complex than previously thought

Raw milk is illegal in many countries as it can be contaminated with potentially harmful microbes.

16 Nov 2008

VIA Pharmaceuticals announces results of phase 2 trials of VIA-2291 in cardiovascular disease

VIA Pharmaceuticals, Inc. has announced the results of two Phase 2 studies of its lead drug, VIA-2291.

10 Nov 2008

Issues on cholesterol: diet, statins and genetics

Genetic lipoprotein disorders are frequently seen in patients with premature coronary artery disease (CAD). An example of strong genetic predisposition is the disorder: familial hypercholesterolemia, where a single gene defect (the low density lipoprotein receptor) contributes to most of the familial expression of CAD.

1 Sep 2008

U.S. approval of Nexavar (sorafenib) for inoperable liver cancer

The U.S. Food and Drug Administration has approved Nexavar (sorafenib) for use in patients with a form of liver cancer known as hepatocellular carcinoma, when the cancer is inoperable.

19 Nov 2007

Is it pancreatitis in acute abdominal pain in acute viral hepatitis?

Hepatitis viruses have a strong tropism for hepatocytes; viral antigen also has been detected in pancreas and gallbladder.

1 Nov 2007

High blood pressure may be due to excess weight in half of overweight adults

As many as 50 percent of overweight men and women with high blood pressure may have hypertension as a result of being overweight, researchers reported at the American Heart Association's 61st Annual Fall Conference of the Council for High Blood Pressure Research.

29 Sep 2007

Study looks at Atorvastatin and cholesterol

Scientists report in the October issue of the Journal of Lipid Research new details about how a drug used against heart disease helps to unclog blood vessels from an excess of cholesterol and fats.

18 Sep 2007

Potential solution to Candida parapsilosis infection

Infection with the fungus Candida parapsilosis is a major problem for individuals in intensive care units, as well as for premature infants and immunocompromised adults.

13 Sep 2007

New player in the control of HDL cholesterol

Researchers have identified a new player in the control of so-called "good" cholesterol that circulates in the bloodstream and reduces heart attack risk, according to a report in the August issue of Cell Metabolism, a publication of Cell Press.

8 Aug 2007

Link between immune system and high plasma lipid levels

Researchers at the University of Chicago have found an unsuspected link between the immune system and high plasma lipid levels (cholesterol and triglycerides in the blood) in mice.

15 Apr 2007

Researchers identify new player in the 'fat from food' game

UCLA investigators have identified a new molecule that may help regulate the delivery of fats to cells for energy and storage.

4 Apr 2007

Scientists identify new molecule that may help regulate the delivery of fats to cells

Published in the April issue of the journal Cell Metabolism, the finding could lead to a better understanding of how we utilize fats from the foods we eat.

4 Apr 2007

New 'platform' for processing dietary fat discovered

A new "platform" with a crucial role in the body's ability to process and take up fat from the diet has been found, according to a report in the April issue of the journal Cell Metabolism, published by Cell Press.

3 Apr 2007

Gene "CGI-58" linked to rare disease activates fat breakdown

A gene earlier linked to a rare disease plays a critical role in the body's "finely tuned balance" of fat storage and break down, new evidence reported in the May Cell Metabolism reveals.

10 May 2006

New diabetes form found by Norwegian researchers

A research group in Bergen has discovered a new form of diabetes. In addition to high blood sugar levels, the disease is characterised by a decrease in pancreatic functioning and reduced fat absorption in the intestine. The discovery may have an impact on the treatment of more usual forms of diabetes.

6 Jan 2006

Women with defects in lipoprotein metabolism may actually be able to bear children without complications

A group of Belgian researchers has determined that a pregnant woman's ability to metabolize fats is determined not only by her genes but by her baby's genes as well.

30 Oct 2005