Lipitor (Atorvastatin) News and Research

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Atorvastatin (INN) (Lipitor, Pfizer), is a member of the drug class known as statins, used for lowering blood cholesterol. It also stabilizes plaque and prevents strokes through anti-inflammatory and other mechanisms. Atorvastatin inhibits HMG-CoA reductase, the rate-determining enzyme located in hepatic tissue that produces mevalonate, a small molecule used in the synthesis of cholesterol and other mevalonate derivatives. This lowers the amount of cholesterol produced which in turn lowers the total amount of LDL cholesterol. Atorvastatin was first synthesized in 1985 by Bruce Roth while working at Parke-Davis Warner-Lambert Company (now Pfizer). With 2006 sales of US$12.9 billion, Lipitor is the largest-selling drug in the world.
Genomas awarded $1.2 million to develop DNA-guided system for management of statin therapy

Genomas awarded $1.2 million to develop DNA-guided system for management of statin therapy

Improving statins

Improving statins

Statins taken after stroke may increase risk of hemorrhagic stroke

Statins taken after stroke may increase risk of hemorrhagic stroke

Discovery of gene responsible for statin-induced muscle pain

Discovery of gene responsible for statin-induced muscle pain

Benefits of statin drugs continue for years

Benefits of statin drugs continue for years

Low levels of good cholesterol risk for heart disease

Low levels of good cholesterol risk for heart disease

Potential new weight-loss wonder drug

Potential new weight-loss wonder drug

New Pfizer HIV drug approved for sale in Europe

New Pfizer HIV drug approved for sale in Europe

Top five prescribed drugs

Top five prescribed drugs

Study looks at Atorvastatin and cholesterol

Study looks at Atorvastatin and cholesterol

Novel angiogenic drugs could revolutionize treatment of peripheral arterial disease

Novel angiogenic drugs could revolutionize treatment of peripheral arterial disease

Stroke outcome improves when patients continue taking cholesterol-lowering drugs

Stroke outcome improves when patients continue taking cholesterol-lowering drugs

Cholesterol-lowering statins may also reduce the risk of Alzheimer's

Cholesterol-lowering statins may also reduce the risk of Alzheimer's

Statin drugs may delay progressive artery damage in children

Statin drugs may delay progressive artery damage in children

Coated aspirin doesn't guarantee problem-free use

Coated aspirin doesn't guarantee problem-free use

Noninvasive ultrasound used to check health of carotid arteries

Noninvasive ultrasound used to check health of carotid arteries

Splitting high-dose pills and swallowing half could save cost

Splitting high-dose pills and swallowing half could save cost

Ranbaxy successfully challenges Atorvastatin patents in Norway

Ranbaxy successfully challenges Atorvastatin patents in Norway

Single-tablet combination of atorvastatin and amlodipine for high blood pressure effective

Single-tablet combination of atorvastatin and amlodipine for high blood pressure effective

Rosuvastatin well tolerated by a broad range of patients with dyslipidemia

Rosuvastatin well tolerated by a broad range of patients with dyslipidemia