Liver News and Research

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U.S. approval of Nexavar (sorafenib) for inoperable liver cancer

The U.S. Food and Drug Administration has approved Nexavar (sorafenib) for use in patients with a form of liver cancer known as hepatocellular carcinoma, when the cancer is inoperable.

19 Nov 2007

MIT researchers devised novel way to create tiny colonies of living human liver cells that model full-sized organs

Liver toxicity is one of the main reasons pharmaceutical companies pull drugs off the market. These dangerous drugs slip through approval processes due in part to the shortcomings of liver toxicity tests. Existing tests rely on liver cells from rats, which do not always respond to toxins the way human cells do. Or they rely on dying human cells that survive for only a few days in the lab.

19 Nov 2007

Rev-erb protein helps maintain the body's correct metabolism

It's well known that the body's energy levels cycle on a 24-hour, or circadian, schedule, and that this metabolic process is fueled by oxygen.

19 Nov 2007

Woman's menstrual cycle provides newly discovered type of stem cell

The cells which thicken the womb wall during a woman's menstrual cycle contain a newly discovered type of stem cell, and could be used in the treatment of damaged and/or old tissue, according to research published in the online open access publication, Journal of Translational Medicine.

16 Nov 2007

Cethromycin achieves all endpoints in second pivotal Phase III Trial for treatment for pneumonia

Advanced Life Sciences Holdings, Inc. (Nasdaq: ADLS), today announced positive results from Trial CL-05, the second of two pivotal phase III clinical trials designed to assess the safety and effectiveness of cethromycin, a novel once-a-day oral antibiotic for the treatment of mild-to-moderate community acquired pneumonia (CAP), the sixth leading cause of death in the United States.

16 Nov 2007

Compound of milk thistle shows anti-cancer effects

Recently, scientists demonstrated the anti-cancer effects of silibinin, a major biologically active compound of milk thistle. Being widely used as a folk remedy for liver diseases, milk thistle is safe and well-tolerated, and it protects the liver from drug or alcohol-related injury.

15 Nov 2007

GlaxoSmithKline implements changes to the US product label for Avandia

GlaxoSmithKline announced today that it is implementing changes to the US product label for Avandia(R) (rosiglitazone maleate), based on an extensive and thorough review by the FDA of myocardial ischemia data on Avandia, the most widely studied oral anti-diabetic medicine available.

15 Nov 2007

New drug may restore memory with Alzheimer's disease

A 2006 study by MetLife found that adults over age 55 fear Alzheimer's disease more than cancer, and with good reason. Alzheimer's creeps up on patients and their families, robbing more than half of all Americans over age 85 of their memory and ability to care for themselves.

14 Nov 2007

Big British problem with booze

A newly-formed group in Britain called the 'Alcohol Health Alliance' is calling for better alcohol prevention and treatment strategies to deal with the escalating alcohol problem.

14 Nov 2007

Most UK citizens susceptible to hep B infection

The failure of the UK to introduce universal hepatitis B immunisation means that most UK citizens are susceptible to infection, warns an infectious diseases expert in this week's BMJ.

13 Nov 2007

High fat diets throw body clock out of sync

The researchers from the Northwestern University and Evanston Northwestern Healthcare in Illinois, suggest that overeating alters the core mechanism of the body clock and disrupts the timing of internal signals such as appetite control.

7 Nov 2007

Overeating alters the core mechanism of the body clock

Our body's 24-hour internal clock, or circadian clock, regulates the time we go to sleep, wake up and become hungry as well as the daily rhythms of many metabolic functions.

6 Nov 2007

New liver model for drug tests

In the early stages of drug development, a drug’s effect is tested in animal experiments.

6 Nov 2007

Inflammation causes insulin resistance not obesity

Researchers at the University of California, San Diego (UCSD) School of Medicine have discovered that inflammation provoked by immune cells called macrophages leads to insulin resistance and Type 2 diabetes.

6 Nov 2007

Diets high in fat shift the timing of the body's internal clock

Diets that are high in fat can shift the timing of the body's internal clock, researchers report in the November issue of Cell Metabolism, a publication of Cell Press.

6 Nov 2007

Hepatitis C treatment reduces the virus but serious liver problems may progress

Patients with chronic hepatitis C and advanced liver disease who did not respond to previous standard therapy experienced significant decreases in their liver enzymes, viral levels, and liver inflammation following treatment with long-term pegylated interferon.

6 Nov 2007