Lou Gehrig's Disease News and Research

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Lou Gehrig's Disease or Amyotrophic Lateral Sclerosis (ALS) is a neurological disorder characterized by progressive degeneration of motor neuron cells in the spinal cord and brain, which ultimately results in paralysis and death. The disease takes its less-scientific name from Lou Gehrig, a baseball player with the New York Yankees in the late 1920s and 1930s, who was forced to retire in 1939 as a result of the loss of motor control caused by the disease.

In 1991, a team of researchers linked familial ALS to chromosome 21. Two years later, the SOD1 gene was identified as being associated with many cases of familial ALS. The enzyme coded for by SOD1 carries out a very important function in cells: it removes dangerous superoxide radicals by converting them into non-harmful substances. Defects in the action of this enzyme mean that the superoxide radicals attack cells from the inside, causing their death. Several different mutations in this enzyme all result in ALS, making the exact molecular cause of the disease difficult to ascertain.

Recent research has suggested that treatment with drugs called antioxidants may benefit ALS patients. However, since the molecular genetics of the disease are still unclear, a significant amount of research is still required to design other promising treatments for ALS.
Novel finding that links ALS/ataxia to cellular stress opens door to new treatment approaches

Novel finding that links ALS/ataxia to cellular stress opens door to new treatment approaches

Study provides new clues to connection between aging and neurodegeneration

Study provides new clues to connection between aging and neurodegeneration

PARP inhibitors show promise for treating and preventing brain disorders

PARP inhibitors show promise for treating and preventing brain disorders

Novel therapeutic approach alleviates ALS-related muscular atrophy in mouse models

Novel therapeutic approach alleviates ALS-related muscular atrophy in mouse models

UC Riverside researcher receives grants to advance cancer, ALS research

UC Riverside researcher receives grants to advance cancer, ALS research

Researchers report unusually high levels of herpesvirus in the brains of people with Alzheimer's disease

Researchers report unusually high levels of herpesvirus in the brains of people with Alzheimer's disease

Aquinnah Pharmaceuticals wins NINDS grant to advance novel therapies for ALS

Aquinnah Pharmaceuticals wins NINDS grant to advance novel therapies for ALS

Researchers seek new approaches to better protect the eye from glaucoma

Researchers seek new approaches to better protect the eye from glaucoma

Study identifies new mechanism involved in development of Lou Gehrig's disease

Study identifies new mechanism involved in development of Lou Gehrig's disease

Schizophrenics' blood samples feature genetic material from more types of microorganisms

Schizophrenics' blood samples feature genetic material from more types of microorganisms

Treg infusions show promise in slowing progression of ALS

Treg infusions show promise in slowing progression of ALS

Large ALS-causing protein aggregates protect rather than harm neurons

Large ALS-causing protein aggregates protect rather than harm neurons

Scientists find link between over-accumulation of mitochondrial iron and Huntington's disease

Scientists find link between over-accumulation of mitochondrial iron and Huntington's disease

Scientists discover basic molecular mechanism that helps understand how ALS works

Scientists discover basic molecular mechanism that helps understand how ALS works

TSRI research offers explanation for why neurons die off in Parkinson's disease

TSRI research offers explanation for why neurons die off in Parkinson's disease

Study sheds light on a key protein associated with brain diseases and dementia

Study sheds light on a key protein associated with brain diseases and dementia

Researchers discover key inner control mechanism of cell's 'smart glue'

Researchers discover key inner control mechanism of cell's 'smart glue'

Study finds novel therapeutic strategy that preserves neuromuscular synapses in ALS mouse model

Study finds novel therapeutic strategy that preserves neuromuscular synapses in ALS mouse model

USC scientists uncover cellular mechanism responsible for ALS and frontotemporal dementia

USC scientists uncover cellular mechanism responsible for ALS and frontotemporal dementia

Researchers discover gene network that regulates the motor neuron development in growing embryo

Researchers discover gene network that regulates the motor neuron development in growing embryo