Lou Gehrig's Disease News and Research

RSS
Lou Gehrig's Disease or Amyotrophic Lateral Sclerosis (ALS) is a neurological disorder characterized by progressive degeneration of motor neuron cells in the spinal cord and brain, which ultimately results in paralysis and death. The disease takes its less-scientific name from Lou Gehrig, a baseball player with the New York Yankees in the late 1920s and 1930s, who was forced to retire in 1939 as a result of the loss of motor control caused by the disease.

In 1991, a team of researchers linked familial ALS to chromosome 21. Two years later, the SOD1 gene was identified as being associated with many cases of familial ALS. The enzyme coded for by SOD1 carries out a very important function in cells: it removes dangerous superoxide radicals by converting them into non-harmful substances. Defects in the action of this enzyme mean that the superoxide radicals attack cells from the inside, causing their death. Several different mutations in this enzyme all result in ALS, making the exact molecular cause of the disease difficult to ascertain.

Recent research has suggested that treatment with drugs called antioxidants may benefit ALS patients. However, since the molecular genetics of the disease are still unclear, a significant amount of research is still required to design other promising treatments for ALS.
Scientists identify basic biological mechanism that kills neurons in ALS

Scientists identify basic biological mechanism that kills neurons in ALS

Dendritic-specific Golgi plays key role in early neuropathy of degenerative brain disease

Dendritic-specific Golgi plays key role in early neuropathy of degenerative brain disease

Scientists stop formation of protein clumps linked to ALS and frontotemporal dementia

Scientists stop formation of protein clumps linked to ALS and frontotemporal dementia

Illumina and Bio‑Rad introduce first next-generation sequencing solution for single-cell analysis

Illumina and Bio‑Rad introduce first next-generation sequencing solution for single-cell analysis

Scientists shed new light on how tau protein transitions from liquid state to solid tangles

Scientists shed new light on how tau protein transitions from liquid state to solid tangles

Genetic factors play significant role in causing ALS, study reveals

Genetic factors play significant role in causing ALS, study reveals

Study shows how RNA splicing errors may trigger development of ALS, FTD

Study shows how RNA splicing errors may trigger development of ALS, FTD

Decades-old drug used to treat malaria reduces toxic protein linked to ALS

Decades-old drug used to treat malaria reduces toxic protein linked to ALS

BGU researchers redesign portion of FDA-approved drug into new molecule to treat ALS

BGU researchers redesign portion of FDA-approved drug into new molecule to treat ALS

New gene variant linked to Lou Gehrig's disease

New gene variant linked to Lou Gehrig's disease

FDA approves new treatment for people with ALS

FDA approves new treatment for people with ALS

Targeted treatment slows progression of two degenerative brain diseases in mice

Targeted treatment slows progression of two degenerative brain diseases in mice

Immunologists discover how rescue proteins delay ‘executioner’ machinery that kills damaged cells

Immunologists discover how rescue proteins delay ‘executioner’ machinery that kills damaged cells

IU study reveals new compounds with potential to boost enzyme that could protect against dementia

IU study reveals new compounds with potential to boost enzyme that could protect against dementia

Scientists discover how misfolded proteins can damage cells’ energy-producing powerhouses

Scientists discover how misfolded proteins can damage cells’ energy-producing powerhouses

New method that detects NMD efficiency could help in treatment of many diseases

New method that detects NMD efficiency could help in treatment of many diseases

Brain-computer interface could revolutionize lives of people with completely locked-in syndrome

Brain-computer interface could revolutionize lives of people with completely locked-in syndrome

Bacterial by-product helps correct gut microbiome imbalance in mouse model of ALS

Bacterial by-product helps correct gut microbiome imbalance in mouse model of ALS

Synthetic molecule appears to reverse Alzheimer's-related neurological damage

Synthetic molecule appears to reverse Alzheimer's-related neurological damage

Equipment for single-cell genomics launched by Illumina and Bio-Rad

Equipment for single-cell genomics launched by Illumina and Bio-Rad