Lou Gehrig's Disease News and Research

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Lou Gehrig's Disease or Amyotrophic Lateral Sclerosis (ALS) is a neurological disorder characterized by progressive degeneration of motor neuron cells in the spinal cord and brain, which ultimately results in paralysis and death. The disease takes its less-scientific name from Lou Gehrig, a baseball player with the New York Yankees in the late 1920s and 1930s, who was forced to retire in 1939 as a result of the loss of motor control caused by the disease.

In 1991, a team of researchers linked familial ALS to chromosome 21. Two years later, the SOD1 gene was identified as being associated with many cases of familial ALS. The enzyme coded for by SOD1 carries out a very important function in cells: it removes dangerous superoxide radicals by converting them into non-harmful substances. Defects in the action of this enzyme mean that the superoxide radicals attack cells from the inside, causing their death. Several different mutations in this enzyme all result in ALS, making the exact molecular cause of the disease difficult to ascertain.

Recent research has suggested that treatment with drugs called antioxidants may benefit ALS patients. However, since the molecular genetics of the disease are still unclear, a significant amount of research is still required to design other promising treatments for ALS.
Home care agencies often wrongly deny Medicare help to the chronically ill

Home care agencies often wrongly deny Medicare help to the chronically ill

Newly described super-silenced DNA reveals novel approach to reprogram cells

Newly described super-silenced DNA reveals novel approach to reprogram cells

Sickle cell patients, families and doctors face a ‘fight for everything’

Sickle cell patients, families and doctors face a ‘fight for everything’

Scientists provide detailed insight into molecular mechanisms of ALS

Scientists provide detailed insight into molecular mechanisms of ALS

Experts highlight need to better address neurosexuality care for patients with neurodisabilities

Experts highlight need to better address neurosexuality care for patients with neurodisabilities

Research brings scientists one step closer to understanding development of ALS

Research brings scientists one step closer to understanding development of ALS

Researcher discovers enzyme pathway involved in ALS pathogenesis

Researcher discovers enzyme pathway involved in ALS pathogenesis

Study points to possible targets for therapeutic intervention in the fight against ALS

Study points to possible targets for therapeutic intervention in the fight against ALS

New study shows how SNO reaction may contribute to Parkinson's disease

New study shows how SNO reaction may contribute to Parkinson's disease

UTHealth professor receives $2.6 million NIH award for brain research

UTHealth professor receives $2.6 million NIH award for brain research

Researchers provide new insight into how nematode's brain controls movement

Researchers provide new insight into how nematode's brain controls movement

Columbia scientists receive grant from CZI to construct atlas of cells in human spinal cord

Columbia scientists receive grant from CZI to construct atlas of cells in human spinal cord

Rutgers scientists use genetic engineering technique to create brain cells for studying Tourette’s

Rutgers scientists use genetic engineering technique to create brain cells for studying Tourette’s

Scientists identify basic biological mechanism that kills neurons in ALS

Scientists identify basic biological mechanism that kills neurons in ALS

Dendritic-specific Golgi plays key role in early neuropathy of degenerative brain disease

Dendritic-specific Golgi plays key role in early neuropathy of degenerative brain disease

Scientists stop formation of protein clumps linked to ALS and frontotemporal dementia

Scientists stop formation of protein clumps linked to ALS and frontotemporal dementia

Illumina and Bio‑Rad introduce first next-generation sequencing solution for single-cell analysis

Illumina and Bio‑Rad introduce first next-generation sequencing solution for single-cell analysis

Scientists shed new light on how tau protein transitions from liquid state to solid tangles

Scientists shed new light on how tau protein transitions from liquid state to solid tangles

Genetic factors play significant role in causing ALS, study reveals

Genetic factors play significant role in causing ALS, study reveals

Study shows how RNA splicing errors may trigger development of ALS, FTD

Study shows how RNA splicing errors may trigger development of ALS, FTD