Lou Gehrig's Disease News and Research

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Lou Gehrig's Disease or Amyotrophic Lateral Sclerosis (ALS) is a neurological disorder characterized by progressive degeneration of motor neuron cells in the spinal cord and brain, which ultimately results in paralysis and death. The disease takes its less-scientific name from Lou Gehrig, a baseball player with the New York Yankees in the late 1920s and 1930s, who was forced to retire in 1939 as a result of the loss of motor control caused by the disease.

In 1991, a team of researchers linked familial ALS to chromosome 21. Two years later, the SOD1 gene was identified as being associated with many cases of familial ALS. The enzyme coded for by SOD1 carries out a very important function in cells: it removes dangerous superoxide radicals by converting them into non-harmful substances. Defects in the action of this enzyme mean that the superoxide radicals attack cells from the inside, causing their death. Several different mutations in this enzyme all result in ALS, making the exact molecular cause of the disease difficult to ascertain.

Recent research has suggested that treatment with drugs called antioxidants may benefit ALS patients. However, since the molecular genetics of the disease are still unclear, a significant amount of research is still required to design other promising treatments for ALS.
Key discovery toward understanding mechanism associated with uncontrollable muscular movements

Key discovery toward understanding mechanism associated with uncontrollable muscular movements

Gray matter in brain associated with language processing among people with a family history of dyslexia

Gray matter in brain associated with language processing among people with a family history of dyslexia

Evidence of pelvic floor nerve injury after routine vaginal birth

Evidence of pelvic floor nerve injury after routine vaginal birth

Zinc plays a crucial role in blindness

Zinc plays a crucial role in blindness

MDA opens center for Lou Gehrig's disease

MDA opens center for Lou Gehrig's disease

Researchers have shown that an experimental vaccine can reduce the amount of neurodegeneration in a mouse model for Parkinson's disease

Researchers have shown that an experimental vaccine can reduce the amount of neurodegeneration in a mouse model for Parkinson's disease

Mitochondria in spinal cords is Lou Gehrig’s disease target according researchers

Mitochondria in spinal cords is Lou Gehrig’s disease target according researchers

Lou Gehrig's disease may be treated or even prevented

Lou Gehrig's disease may be treated or even prevented

Discovery of gene that causes a rare juvenile-onset form of amyotrophic lateral sclerosis (ALS)

Discovery of gene that causes a rare juvenile-onset form of amyotrophic lateral sclerosis (ALS)

Neuroscientists have overcome a major obstacle in gene therapy research

Neuroscientists have overcome a major obstacle in gene therapy research

Parkinson's disease breakthrough

Parkinson's disease breakthrough

New patent has potential for the treatment of obesity

New patent has potential for the treatment of obesity

Lou Gehrig’s disease gene discovered

Lou Gehrig’s disease gene discovered

Researchers have discovered a genetic mutation associated with an inherited form of motor neuron disease

Researchers have discovered a genetic mutation associated with an inherited form of motor neuron disease

On-board brain chips could help stroke and cerebral palsy victims

On-board brain chips could help stroke and cerebral palsy victims

Identification of first protein biomarkers to help patients with amyotrophic lateral sclerosis

Identification of first protein biomarkers to help patients with amyotrophic lateral sclerosis

Brain signals could act as remote controls

Brain signals could act as remote controls