Lupus Erythematosus News and Research

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PALS program effective in ensuring diverse representation in lupus clinical trials

The Lupus Research Alliance and its affiliate Lupus Therapeutics presented data at ACR Convergence 2022 with results showing the effectiveness of a pilot peer education program called the Patient Advocates for Lupus Studies (PALS), in increasing knowledge, perception, and willingness among people with Systemic Lupus Erythematosus (SLE) to participate in clinical trials.

14 Nov 2022

Oral deucravacitinib shows promise in patients with active lupus

Tyrosine kinases are enzymes that play central roles in signaling by cytokines involved in the pathogenesis of autoimmune diseases, including lupus.

14 Nov 2022

First placebo-controlled long-term trial of anifrolumab shows positive results in patients with lupus

Type I interferon (IFN) is a powerful immune activator that is present at high levels in the majority of patients with lupus, an autoimmune disease. In Arthritis & Rheumatology, researchers report positive results from the first placebo-controlled long-term trial of anifrolumab-;a human monoclonal antibody that targets the type I IFN receptor-;in patients with lupus.

14 Nov 2022

Lower hydroxychloroquine dosing results in increased SLE-related hospitalizations, study finds

New research presented this week at ACR Convergence 2022, the American College of Rheumatology's annual scientific meeting, found that the recommended weight-based or non-weight-based dose of hydroxychloroquine led to more hospitalizations for flares among patients with systemic lupus erythematosus

8 Nov 2022

Shared genetic effects between the autoimmune disease systemic lupus erythematosus and the clinical consequences of COVID-19

Researchers identified a genetic association signal, via genome-wide association studies, between severe COVID-19 with systemic lupus erythematosus, an autoimmune disease.

7 Nov 2022

Dietary components do not have impact on RMD outcomes

In 2022, EULAR - the European Alliance of Rheumatology Associations - published new recommendations regarding lifestyle behaviors and work participation to prevent progression of rheumatic and musculoskeletal diseases (RMDs).

1 Nov 2022

The Black Death may have influenced the evolution of genes involved in immune responses against pathogens

Researchers gathered empirical evidence that past pandemics due to infectious pathogens shaped the present-day susceptibility of humans to diseases, such as autoimmune diseases.

24 Oct 2022

Overview of the roles of neutrophils in systemic autoimmune and autoinflammatory diseases

Researchers assess the role of neutrophil extracellular traps (NETs) in systemic autoimmune and autoinflammatory disorders.

23 Oct 2022

Scientists receive $8.297 NIH grant to continue funding a Center for Lupus Research

A multi-institutional team of scientists, led by researchers at Weill Cornell Medicine's Gale and Ira Drukier Institute for Children's Health, have received a five-year $8.297 grant to continue funding a Center for Lupus Research.

21 Oct 2022

Study reviews hydroxychloroquine and remdesivir antiviral potency against SARS‐CoV‐2

In a new study, researchers outlined the synthesis and the possible mechanism of action (MOA) of two potential severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) repurposing drug candidates.

17 Oct 2022

Researchers explore single-cell sequencing technologies to understand molecular mechanisms of autoimmune diseases

A new review discussed the applications of single-cell ribonucleic acid sequencing (scRNA-seq) in understanding autoimmune disorders.

17 Oct 2022

Could COVID-19 infections trigger a relapse of mycosis fungoides or other cutaneous T-cell lymphomas?

Recently, authors highlighted the potential role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in triggering the relapse of mycosis fungoides, a type of cutaneous T-cell lymphoma.

17 Oct 2022

Immune-mediated inflammatory diseases following COVID-19

Researchers explore the potential association between SARS-CoV-2 infection and immune-mediated inflammatory diseases.

12 Oct 2022

Review on COVID-19 biomedical waste-derived microplastic toxicity

In a new study, researchers reviewed existing literature on the biomedical waste source, elements, and the recent upsurge of microplastics during the SARS-CoV-2 pandemic.

11 Oct 2022

Study establishes a feasible combination therapeutic strategy for ulcerative colitis

Despite recent advancements in our knowledge of the pathogenic mechanisms of ulcerative colitis, there is still a considerable unmet medical need for the treatment of ulcerative colitis.

29 Sep 2022

Study explores the effect of age-associated B cells on COVID-19 vaccine-induced immunity

In a new study, a team of researchers explored the effect of immune checkpoint blockade (ICB)-induced expansion of age-associated B cells (ABCs) on COVID-19 vaccine-derived humoral immunity in patients with cancer and inborn errors of immunity (IEI).

22 Sep 2022

Patients with autoimmune diseases at greater risk of complications after heart attack

In a recent study published in the Journal of the American Heart Association, researchers assessed midterm and management outcomes of acute myocardial infarction (AMI) among patients with rheumatic immune-mediated inflammatory diseases (IMIDs).

18 Sep 2022

New data analysis approach could help uncover the genetic basis of many diseases

In the era of Big Data, obtaining a huge amount of information is the easy part; knowing what to do with it is another story entirely.

9 Sep 2022

Clinical trial shows efficacy and safety of belimumab in East Asian adults with lupus nephritis

This prespecified subgroup analysis of East Asian adults who participated in a phase 3 clinical trial of belimumab added to standard therapy vs. placebo added to standard therapy for lupus nephritis shows earlier and more sustained improvement in kidney outcomes with the addition of belimumab.

2 Sep 2022

The origins, breadth, and resolution of autoreactivity in severe COVID-19

Researchers assessed naïve B cells and autoreactivity in severe COVID-19.

2 Sep 2022

Lupus Erythematosus News and Research

PALS program effective in ensuring diverse representation in lupus clinical trials

Oral deucravacitinib shows promise in patients with active lupus

First placebo-controlled long-term trial of anifrolumab shows positive results in patients with lupus

Lower hydroxychloroquine dosing results in increased SLE-related hospitalizations, study finds

Shared genetic effects between the autoimmune disease systemic lupus erythematosus and the clinical consequences of COVID-19

Dietary components do not have impact on RMD outcomes

The Black Death may have influenced the evolution of genes involved in immune responses against pathogens

Overview of the roles of neutrophils in systemic autoimmune and autoinflammatory diseases

Scientists receive $8.297 NIH grant to continue funding a Center for Lupus Research

Study reviews hydroxychloroquine and remdesivir antiviral potency against SARS‐CoV‐2

Researchers explore single-cell sequencing technologies to understand molecular mechanisms of autoimmune diseases

Could COVID-19 infections trigger a relapse of mycosis fungoides or other cutaneous T-cell lymphomas?

Immune-mediated inflammatory diseases following COVID-19

Review on COVID-19 biomedical waste-derived microplastic toxicity

Study establishes a feasible combination therapeutic strategy for ulcerative colitis

Study explores the effect of age-associated B cells on COVID-19 vaccine-induced immunity

Patients with autoimmune diseases at greater risk of complications after heart attack

New data analysis approach could help uncover the genetic basis of many diseases

Clinical trial shows efficacy and safety of belimumab in East Asian adults with lupus nephritis

The origins, breadth, and resolution of autoreactivity in severe COVID-19

One Health, One Mission: The World Organisation for Animal Health on the AMR Frontline

Uniting Against Resistance: The World Health Organization for World Antimicrobial Awareness Week 2023

Tackling Antimicrobial Resistance: A Conversation with Dr. Beverley Isherwood

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