Lymph Node News and Research

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Lymph is clear or white fluid that travels through vessels, moves within tissues and work to keep all the parts of the body clean. After passing through the channels of the lymphatic system they drain into the lymph nodes. The lymph nodes act as filters along the lymphatic system. These nodes trap germs like bacteria, viruses, toxins as well as cancer cells and ensure that these are removed from the body.

Neoadjuvant chemotherapy can eliminate need for regional nodal irradiation in breast cancer

For patients whose breast cancer converted from lymph node-positive to lymph node-negative disease after neoadjuvant chemotherapy, skipping adjuvant regional nodal irradiation (RNI) did not increase the risk of disease recurrence or death five years after surgery, according to results from the NRG Oncology/NSABP B-51/RTOG 1304 clinical trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

6 Dec 2023

Resident Tregs found to remain in certain lymph nodes for a long time

The immune system is fast when it comes to fighting viruses, bacteria and other pathogens. But it also has to know when not to attack - for example, harmless substances such as pollen or house dust, which otherwise trigger allergic reactions.

30 Oct 2023

Oxford Vaccine Group launches a pioneering study into human immunity

This study will test the responses of cells in lymph nodes before and after immunization with flu and COVID-19 vaccines and compare reactions in older and younger adults.

25 Oct 2023

Neoadjuvant pembrolizumab achieves major pathologic response in more than half of patients with resectable melanoma

In exploratory analyses of results from the SWOG S1801 trial in patients with stage III-IV resectable melanoma, researchers saw a major pathologic response in more than half of surgical specimens taken from patients who had been treated with neoadjuvant (pre-operative) pembrolizumab.

24 Oct 2023

Online educational materials about breast surgery often difficult to access and understand

Women with breast cancer must often make complex decisions about surgery and treatment options during an already stressful time in their lives, and many of these women may turn to the wide variety of materials available online.

20 Oct 2023

Researchers develop AI-based tool for estimating cancer patient's chances for survival

Researchers have developed an artificial intelligence (AI)–based tool for estimating a newly diagnosed cancer patient's chances for surviving long term, according to a study presented at the American College of Surgeons (ACS) Clinical Congress 2023.

20 Oct 2023

Cracking the code: recent discoveries transform our understanding of cancer-immunity cycle

In a recent review published in Immunity, researchers reviewed tumor-immunity cycle data.

13 Oct 2023

Larger lymph node threshold helps facilitate better risk stratification and treatment decisions in nasopharyngeal carcinoma

According to the American Journal of Roentgenology (AJR), using a 6-mm threshold, rather than a 5-mm threshold, helps facilitate better risk stratification and treatment decisions in patients with nasopharyngeal carcinoma (NPC).

29 Sep 2023

Study sheds light on immune cells' ability to collectively migrate through complex environments

When fighting disease, our immune cells need to reach their target quickly. Researchers at the Institute of Science and Technology Austria (ISTA) now discovered that immune cells actively generate their own guidance system to navigate through complex environments.

1 Sep 2023

Novel multi-epitope subunit vaccine induces robust immune response against Epstein-Barr virus

Scientists have developed a lymph node-targeted multi-epitope subunit vaccine that induces strong humoral and cellular immune responses against EBV in mice.

14 Aug 2023

New trial to assess sentinel lymph node removal during surgery for early-stage endometrial cancer

University of Queensland researchers have received a $3.1 million grant for a trial which could revolutionize endometrial cancer treatment.

7 Aug 2023

Study sheds light on how breast cancer spreads to lymph nodes

Lymph nodes are one of the body's first lines of defense against disease. Immune cells are dispatched from these biological police stations to fight off intruders.

26 Jul 2023

Predicting bone metastases type in prostate cancer using MRI

Researchers investigated the differences in prostate MRI findings and clinical characteristics between patients with prostate cancer exhibiting bone metastases.

20 Jul 2023

Breast cancer and MEN1: exploring the connection

Researchers evaluated the role of Multiple Endocrine Neoplasia 1 (MEN1) messenger ribonucleic acid (mRNA) in breast cancer

17 Jul 2023

Arima Genomics continues momentum toward clinic with formation of clinical advisory board

Arima Genomics, Inc., a company leveraging 3D genomics to reveal actionable insights to improve human health and drive discovery in the life sciences, today announced the formation of a clinical advisory board to help the company advance its 3D genomics technologies into the clinical oncology and biopharmaceutical markets.

From Arima Genomics, Inc. 5 Jul 2023

Insights gained from genetically modified pig heart transplantation

Researchers described a genetically engineered pig cardiac xenotransplantation in a 57-year-old male patient.

3 Jul 2023

Are a high-refined carbohydrate diet and the alterations resulting from its intake linked to small intestine changes?

Researchers investigated whether a high-refined carbohydrate diet and associated metabolic alterations could cause small intestinal dysregulation.

27 Jun 2023

New research finds most women diagnosed with early breast cancer can expect to become long-term survivors

Researchers reported longitudinal outcomes among British women suffering from early invasive-type breast tumors as their initial tumor and those initially treated by surgical methods such as conservative surgery or mastectomy.

16 Jun 2023

Study provides a possible treatment option for prostate cancer resistant to hormone therapy

Prostate cancer is the most-commonly diagnosed malignancy and the second leading cause of cancer death among men in the United States.

12 Jun 2023

UVA discoveries highlight the different roles of blood vessels in solid tumors

Two new discoveries from the Dudley lab at UVA Cancer Center highlight the different roles of blood vessels in solid tumors – and the findings could help prevent breast cancer from spreading and enhance the effectiveness of one of the most important new cancer treatments in many years.

4 Jun 2023