Lymph Nodes News and Research

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Unmasking the culprits behind long-term arm problems in breast cancer patients

A new review paper was published in Oncotarget's Volume 14 on December 1, 2023, entitled, "Risk factors for long-term arm morbidities following breast cancer treatments: A systematic review."

11 Dec 2023

Study reveals genetic roots of hodgkin lymphoma, offering hope for new treatments

A Stanford Medicine-led, international study of hundreds of samples from patients with Hodgkin lymphoma has shown that levels of tumor DNA circulating in their blood can identify who is responding well to treatment and others who are likely to experience a disease recurrence -; potentially letting some patients who are predicted to have favorable outcomes forgo lengthy treatment.

11 Dec 2023

Key role of ion and water influx in T cell migration uncovered

Research reveals that T cell migration relies on ion and water influx for actin polymerization and movement, with the WNK1 kinase playing a critical role in regulating these processes, offering new insights into adaptive immunity.

10 Dec 2023

Researchers discover next-gen lipid nanoparticles for muscle-focused mRNA delivery

A team of researchers based at the University of Toronto's (U of T) Leslie Dan Faculty of Pharmacy has discovered a novel ionizable lipid nanoparticle that enables muscle-focused mRNA delivery while minimizing off-target delivery to other tissues.

8 Dec 2023

Study underscores need for primary prevention in advanced breast cancer

While regular screenings may decrease the chance of diagnosis of advanced breast cancer in some women and lead to a 20% reduction in breast cancer mortality, other women will be diagnosed with advanced breast cancer despite screening at regular intervals.

7 Dec 2023

Neoadjuvant chemotherapy can eliminate need for regional nodal irradiation in breast cancer

For patients whose breast cancer converted from lymph node-positive to lymph node-negative disease after neoadjuvant chemotherapy, skipping adjuvant regional nodal irradiation (RNI) did not increase the risk of disease recurrence or death five years after surgery, according to results from the NRG Oncology/NSABP B-51/RTOG 1304 clinical trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

6 Dec 2023

Sympathetic nervous system and immune interplay: Key to metabolic regulation

A review in Advanced Science explores the interaction between the immune system and the sympathetic nervous system in regulating vital metabolic organs like the pancreas, liver, and adipose tissues. This comprehensive analysis provides insights into the neuroimmune relationships affecting metabolism, offering potential new therapeutic strategies for metabolic diseases.

5 Dec 2023

Study may shed light on new ways to counteract the effects of high blood pressure on cognition

A study supported by the National Institutes of Health suggests that the response of immune system cells inside the protective covering surrounding the brain may contribute to the cognitive decline that can occur in a person with chronic high blood pressure.

5 Dec 2023

Study finds diet-derived trans-vaccenic acid boosts anti-tumor immunity

Dietary components that impact anti-tumor immunity.

28 Nov 2023

New drug cocktail reverses brain swelling and improves recovery in animal models of brain injury

Cerebral edema, the dangerous brain swelling that occurs after traumatic brain injury (TBI), can increase risk of death tenfold and significantly worsen prospects for recovery in brain function.

15 Nov 2023

Brazzein and monellin: Safe alternatives to sugar, new research confirms

Toxicity assessments of monellin and brazzein.

10 Nov 2023

New pathologic scoring system could help predict survival in lung cancer patients

A new pathologic scoring system that accurately assesses how much lung tumor is left after a patient receives presurgical cancer treatments can be used to predict survival, according to new research led by investigators at the Bloomberg~Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center and the Mark Foundation Center for Advanced Genomics and Imaging at the Johns Hopkins University.

6 Nov 2023

$13M NIH grant funds research to rejuvenate immune system in older adults

University of Arizona Health Sciences researchers received a $13.1 million grant from the National Institute on Aging to continue studies aimed at rejuvenating the immune system of older people in order to improve health throughout the lifespan.

1 Nov 2023

Resident Tregs found to remain in certain lymph nodes for a long time

The immune system is fast when it comes to fighting viruses, bacteria and other pathogens. But it also has to know when not to attack - for example, harmless substances such as pollen or house dust, which otherwise trigger allergic reactions.

30 Oct 2023

Study unravels the prognostic paradox of isolated cardiac sarcoidosis

Sarcoidosis is a complex inflammatory disease that causes the harmful accumulation of tiny clumps of cells called granulomas in the body.

30 Oct 2023

Oxford Vaccine Group launches a pioneering study into human immunity

This study will test the responses of cells in lymph nodes before and after immunization with flu and COVID-19 vaccines and compare reactions in older and younger adults.

25 Oct 2023

Mapping the mysteries: Study reveals surprising hubs of human immune cells

Researchers in Israel comprehensively mapped the distribution and mass of primary immune cells across human tissues. This groundbreaking study, using advanced biotechnological methods, provides insights into the immune system's cellular network, challenging existing notions and emphasizing the bone marrow, lymph nodes, and spleen as primary immune cell reservoirs.

24 Oct 2023

Fluorescence lifetime imaging shows promise for improved tumor detection

Removing a patient's tumor while sparing healthy tissue requires exquisite precision, but often surgeons must rely on their eyes and hands to determine where to cut.

16 Oct 2023

Study reveals previously unappreciated role for innate immune cells in early stages of TB infection

A new study from the University of Pittsburgh Center for Vaccine Research published today in the Journal of Experimental Medicine describes a previously unappreciated role for a class of immune cells in the early stages of tuberculosis (TB) infection.