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Role of the transketolase-like 1 gene in the development of the modern human brain

In a new study, researchers demonstrated how transketolase-like 1 (TKTL1) gene expression influenced neocortical neurogenesis in modern humans.

12 Sep 2022

Single amino acid change in TKTL1 protein underlies greater neuron production in modern humans than Neandertals

Researchers from Dresden uncover a greater neuron production in the frontal lobe during brain development in modern humans than Neandertals, due to the change of a single amino acid in the protein TKTL1.

9 Sep 2022

Inhibiting a key metabolic enzyme selectively kills melanoma cells and stops tumor growth

Researchers at Sanford Burnham Prebys, led by Ze'ev Ronai, Ph.D., have shown for the first time that inhibiting a key metabolic enzyme selectively kills melanoma cells and stops tumor growth.

1 Sep 2022

SARS-CoV-2 mutational spectra based on reconstructed phylogenetic tree

In a new study, researchers assessed the impact of mutagenesis on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome and the effects of mutations in the neutral regions and non-neutral regions of the genome.

25 Aug 2022

Intake of lysine prevents hypertensive kidney disease in animal models

Can you eat your way out of a kidney disease? Perhaps you can – according to a new study from Aarhus University.

19 Aug 2022

Researchers unravel the mechanism of teixobactin at the atomic level

Researchers explored the mechanisms underlying the bactericidal action of teixobactin at an atomic level.

8 Aug 2022

Researchers discover new key protection against COVID-19 in saliva

The novel coronavirus (SARS-CoV-2) has spread around the world at an unprecedented rate, evading containment countermeasures.

19 Jul 2022

Researchers uncover a novel interplay between coral pathogen and other coral commensal bacteria

Coral is a complicated holobiont, harboring an array of life forms at different scales, including coral cells, zooxanthellae, and associated bacteria, archaea, and viruses.

1 Jul 2022

New study investigates the epigenetic drift of time passing

A new research paper was published in Aging (Aging-US) on the cover of Volume 14, Issue 12, entitled, "Time makes histone H3 modifications drift in mouse liver."

30 Jun 2022

Gene expression regulation by N6-methyladenosine

A recent study published in Molecular Cell reviewed the control of gene expression by N6-methyladenosine (m6A), a modified nucleotide in the messenger ribonucleic acid (mRNA).

22 Jun 2022

The virucidal effects of tea tree oil against FCoVII and HCoV-OC43

Researchers assessed the probable efficacy of tea tree oil (TTO) as a natural disinfectant against SARS-CoV-2 using the human coronavirus OC43 (HCoV-OC43) and feline coronavirus (FCoVII) as surrogate models.

14 Jun 2022

Genomic analysis of the 2022 monkeypox outbreak

In a recent study posted to the bioRxiv* pre-print server, researchers analyzed two genomic sequences of the Monkeypox virus from Belgium and Portugal termed ITM001 and PT0001, respectively, to show that the May 2022 Monkeypox outbreak most likely originated from the West African clade of the virus.

14 Jun 2022

Study reports SARS-CoV-2 accessory proteins downregulate MHC-I expression using distinct mechanisms

Researchers observed SARS-CoV-2 downregulates the expression of MHC class I molecules.

23 May 2022

RNA binding-induced structural dynamics of SARS-CoV-2 nucleocapsid protein

Researchers predict structure models of the full-length SARS-CoV-2 N protein in both the presence and absence of RNA.

19 May 2022

Marine bioactive compounds against SARS-CoV-2

A new review paper published in the journal Environmental Science and Pollution Research aimed to determine the possibilities of using biologically active compounds derived from various chemical classes of marine organisms against SARS-CoV-2 infection at various stages of the life cycle of the virus.

6 May 2022