Lysosomes News and Research

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Small clinical trial shows promise for treating rare neurodegenerative disease

Results of a small clinical trial show promise for treating a rare neurodegenerative condition that typically kills those afflicted before they reach age 20.

11 Aug 2017

Researchers develop set of tools to trace path of proteins linked to Parkinson's disease

As neurodegenerative disorders such as Parkinson's and Alzheimer's disease progress, misfolded proteins clump together in neurons, recruiting normal proteins in the cell to also misfold and aggregate.

4 Aug 2017

MIT engineers devise noninvasive way to assess cell's mechanical properties

The stiffness or elasticity of a cell can reveal much about whether the cell is healthy or diseased. Cancer cells, for instance, are known to be softer than normal, while asthma-affected cells can be rather stiff.

3 Aug 2017

Researchers unravel how acidic conditions favor protein misfolding in deadly diseases

Using an array of modern biochemical and structural biology techniques, researchers from Boston University School of Medicine have begun to unravel the mystery of how acidity influences a small protein called serum amyloid A (SAA).

28 Jul 2017

Researchers understand how to prevent severe weight loss in cancer patients

Many cancer patients are susceptible to potentially lethal weight loss. Now researchers understand better why this happens, and perhaps how to prevent the condition.

25 Jul 2017

NIH researchers show how investigational drug works against rare, fatal genetic disease

Scientists have demonstrated how an investigational drug works against a rare, fatal genetic disease, Niemann-Pick type C1 (NPC1).

17 Jul 2017

Researchers gain new insights into how proteins help immune defense mechanism in the body

Researchers have gained new insights into the mechanisms with which certain proteins help the immune defense mechanism in the human body.

4 Jul 2017

Emory scientists show how same enzyme spurs Alzheimer's and Parkinson's disease

Alzheimer's disease and Parkinson's disease are not the same. They affect different regions of the brain and have distinct genetic and environmental risk factors.

4 Jul 2017

Magnetic nanoparticle aggregates can induce death of cancer cells

An international team in which a UPM researcher is involved has shown that it is possible to mechanically destroy cancer cells by rotating magnetic nanoparticles attached to them in elongated aggregates.

13 Jun 2017

Researchers discover molecular signaling circuit that regulates autophagy

Autophagy is the recycling process by which our cells keep themselves young. They continually break down and renew small parts of themselves in a kind of self-digestion; this helps to counteract harmful deposits which may form.

1 Jun 2017

Study reveals how enzyme allows brain tumors to grow despite harsh surroundings

All cancer tumors have one thing in common – they must feed themselves to grow and spread, a difficult feat since they are usually in a tumor microenvironment with limited nutrients and oxygen.

26 May 2017

Study findings suggest how progranulin deficiency causes frontotemporal dementia

In a recent study in Human Molecular Genetics, researchers from VIB and KU Leuven led by prof. Philip Van Damme, reveal a novel function for progranulin in lysosomes: it acts as chaperone of the lysosomal protease cathepsin D. The results were obtained in collaboration with Prof. Paul Saftig from the University of Kiel.

8 May 2017

Brain cancer patient treated with malaria drug shows dramatic improvement

After her brain cancer became resistant to chemotherapy and then to targeted treatments, 26-year-old Lisa Rosendahl's doctors gave her only a few months to live.

19 Apr 2017

Researchers discover key to reveal secret of reversible aging recovery

DGIST's research team discovered substances that can induce reversible aging* recovery and identified an aging recovery mechanism using these substances.

3 Apr 2017

Scientists discover how misfolded proteins can damage cells’ energy-producing powerhouses

Working with yeast and human cells, researchers at Johns Hopkins say they have discovered an unexpected route for cells to eliminate protein clumps that may sometimes be the molecular equivalent of throwing too much or the wrong trash into the garbage disposal.

3 Mar 2017

Research provides insights on how pathogens escape process of autophagy

Our immune system has various ways to deal with threats from the outside like pathogens. One of the defence mechanisms is a process called autophagy.

3 Mar 2017

Doctoral student in biology investigating cause of hereditary neurodegenerative disease

Babita Adhikari Dhungel, doctoral student in biology from Nepal, is researching the cause of CLN8 disease, which is a form of neuronal ceroid lipofuscinoses.

3 Mar 2017

Scientists discover treatment that improves symptoms in mouse model of juvenile Batten disease

Researchers at Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital and King's College London have discovered a treatment that improves the neurological symptoms in a mouse model of juvenile Batten disease.

6 Feb 2017

Scientists identify Smurf1 protein that plays role in autophagy of TB bacteria

UT Southwestern Medical Center researchers have identified a protein that is central to the immune system's ability to recognize and destroy the bacterium responsible for the global tuberculosis (TB) epidemic.

12 Jan 2017

A Chain of Life for a Rare Neurodegenerative Disease

Researchers in Japan have improved a potential treatment for a rare genetic disease, decreasing its negative toxic effects by threading it onto a dumb-bell-shaped chain and holding it in place until it reaches its target.

22 Dec 2016

Lysosomes News and Research

Small clinical trial shows promise for treating rare neurodegenerative disease

Researchers develop set of tools to trace path of proteins linked to Parkinson's disease

MIT engineers devise noninvasive way to assess cell's mechanical properties

Researchers unravel how acidic conditions favor protein misfolding in deadly diseases

Researchers understand how to prevent severe weight loss in cancer patients

NIH researchers show how investigational drug works against rare, fatal genetic disease

Researchers gain new insights into how proteins help immune defense mechanism in the body

Emory scientists show how same enzyme spurs Alzheimer's and Parkinson's disease

Magnetic nanoparticle aggregates can induce death of cancer cells

Researchers discover molecular signaling circuit that regulates autophagy

Study reveals how enzyme allows brain tumors to grow despite harsh surroundings

Study findings suggest how progranulin deficiency causes frontotemporal dementia

Brain cancer patient treated with malaria drug shows dramatic improvement

Researchers discover key to reveal secret of reversible aging recovery

Scientists discover how misfolded proteins can damage cells’ energy-producing powerhouses

Research provides insights on how pathogens escape process of autophagy

Doctoral student in biology investigating cause of hereditary neurodegenerative disease

Scientists discover treatment that improves symptoms in mouse model of juvenile Batten disease

Scientists identify Smurf1 protein that plays role in autophagy of TB bacteria

A Chain of Life for a Rare Neurodegenerative Disease

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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