MERS CoV News and Research

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In recent history, we have witnessed the emergence of several different life-threatening viruses. In addition to causing serious public health concerns around the globe, they have been responsible for significant human morbidity and mortality. Modern life that entails uncurtailed travel of humans and goods means that initially localized outbreaks may pose a risk of transmission anywhere in the world.

Potential SARS-CoV-2 antivirals based on host miRNAs

A recent research paper posted to the bioRxiv* preprint server demonstrated micro ribonucleic acids (miRNAs) as potential antiviral options against various coronaviruses (CoVs), including severe acute respiratory syndrome CoV 2 (SARS-CoV-2).

21 Jun 2022

Study finds traditional African drug inhibits growth of SARS-CoV-2 infection

Researchers evaluated the efficacy of PHELA, a traditional African drug, against SARS-CoV-2 in vitro.

21 Jun 2022

SARS-CoV-2 variants of concern exhibit divergent interactions with host proteases

In a recent study posted to the bioRxiv* preprint server, researchers at Weill Cornell Medical College assessed the cleavability of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) and related coronaviruses by several proteases of the host.

19 Jun 2022

Scientists explore effectiveness of neutralizing antibodies against SARS-CoV-2 Omicron variant

Researchers assessed the impact of SARS-CoV-2-neutralizing antibodies on the SARS-CoV-2 Omicron variant.

17 Jun 2022

The potential mechanisms of SARS-CoV-2 to induce DNA damage

Researchers described potential mechanisms of coronaviruses that could lead to DNA damage and the potential link between SARS-CoV-2 activity and such mechanisms.

14 Jun 2022

Multi-national scientific task force needed to monitor zoonotic viruses long-term

A new study aimed to identify the main host, intermediate hosts, as well as other animal reservoirs for both SARS-CoV-2 and the monkeypox virus.

13 Jun 2022

SARS-CoV-2 ORF8 protein binds to dendritic cells and induces a hyper-inflammatory cytokine storm

In a recent study posted to the bioRxiv* pre-print server, researchers examined how the interaction of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) open reading frame 8 (ORF8) protein with host dendritic cells (DCs) induced cytokine storm.

8 Jun 2022

Researchers report novel interactions between the SARS-CoV-2 S protein and estrogen receptor alpha

Researchers profiled the binding sites of the entire SARS-CoV-2 spike protein sequence.

26 May 2022

Can human coronaviruses infect the GI tract?

Researchers review current findings on how human coronaviruses like SARS-CoV-2 might cause GI symptoms.

22 May 2022

Study demonstrates that ATV006 is orally bioavailable and has potent efficacy against SARS-CoV-2

A new study has revealed that ATV006, which is a 5′-hydroxyl-isobutyryl prodrug, possesses extraordinary oral pharmaco-kinetic (PK) profiles in rats and cynomolgus monkeys and exhibited significant antiviral activity against ancestral SARS-COV-2 strain as well as VOCs.

20 May 2022

Only some coronaviruses found to have pandemic-causing potential

In a new study, scientists focused on resolving the mystery of why some coronaviruses have the potential of causing a pandemic while others do not.

18 May 2022

Impact of cannabidiol on cellular innate immune responses to SARS-CoV-2 genes

A new study published in the journal Life Sciences has focused on examining the effects of ORF8 and ORF10 genes and SARS-CoV-2 Membrane (M) protein on apoptosis.

17 May 2022

Hormone replacement therapy associated with reduction in mortality from COVID-19

A new paper in Family Practice, published by Oxford University Press, indicates that receiving hormone replacement therapy within six months of a recorded diagnosis of COVID-19 was associated with a reduction in mortality from the disease.

17 May 2022

Exploring simultaneous and sequential COVID-19 vaccine candidate

Researchers developed novel lipid nanoparticle (LNP)-based messenger ribonucleic acid vaccine formulations against three pathogenic coronaviruses.

10 May 2022

The potential for SARS-CoV-2 to be transmitted biologically or mechanically by arthropods

Researchers examined results from field studies, laboratory-based research, and environmental studies to analyze the potential of SARS-CoV-2 transmission either biologically or mechanically among arthropods.

10 May 2022

The potential impact of oral vaccination against COVID-19 on transmission to naïve individuals studied in a hamster infection model

A recent article published in Science Translational Medicine demonstrated that mucosally delivered adenovirus type 5 (Ad5)-based COVID-19 vaccination minimized COVID-19 transmission and severity.

9 May 2022

MERS CoV News and Research

Further Reading

Potential SARS-CoV-2 antivirals based on host miRNAs

Study finds traditional African drug inhibits growth of SARS-CoV-2 infection

SARS-CoV-2 variants of concern exhibit divergent interactions with host proteases

Scientists explore effectiveness of neutralizing antibodies against SARS-CoV-2 Omicron variant

The potential mechanisms of SARS-CoV-2 to induce DNA damage

Multi-national scientific task force needed to monitor zoonotic viruses long-term

SARS-CoV-2 ORF8 protein binds to dendritic cells and induces a hyper-inflammatory cytokine storm

Researchers report novel interactions between the SARS-CoV-2 S protein and estrogen receptor alpha

Can human coronaviruses infect the GI tract?

Study demonstrates that ATV006 is orally bioavailable and has potent efficacy against SARS-CoV-2

Only some coronaviruses found to have pandemic-causing potential

Impact of cannabidiol on cellular innate immune responses to SARS-CoV-2 genes

Hormone replacement therapy associated with reduction in mortality from COVID-19

Exploring simultaneous and sequential COVID-19 vaccine candidate

The potential for SARS-CoV-2 to be transmitted biologically or mechanically by arthropods

The potential impact of oral vaccination against COVID-19 on transmission to naïve individuals studied in a hamster infection model

Multivalent messenger ribonucleic acid-lipid nanoparticle vaccines against SARS-CoV-2

Green tea catechin as pan-coronavirus attachment inhibitor

Free fatty acid-binding pocket found to be preserved across spike proteins of beta coronaviruses

Evidence of increased intrinsic cleavability of SARS-CoV-2 Omicron spike protein by host cell furin

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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