MERS CoV News and Research

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In recent history, we have witnessed the emergence of several different life-threatening viruses. In addition to causing serious public health concerns around the globe, they have been responsible for significant human morbidity and mortality. Modern life that entails uncurtailed travel of humans and goods means that initially localized outbreaks may pose a risk of transmission anywhere in the world.

Posaconazole found to be effective as a small molecule fusion inhibitor against SARS-CoV-2 variants

Researchers evaluated the importance of the Ex3Lx6L motif in SARS-CoV-2 entry into host cells mediated by the spike protein syncytium formation and membrane fusion.

22 Mar 2022

Study explores novel antiviral activity of PAD inhibitors against human beta-coronaviruses HCoV-OC43 and SARS-CoV-2

In a new study, researchers aimed to determine if peptidyl-arginine deiminases inhibitors may be used as a novel class of host-targeting antivirals against human coronaviruses.

21 Mar 2022

Multiple inter-variant recombination events identified in Omicron subvariants

Newly emerging and circulating Omicron subvariants have originated partially through recombination with other variants.

20 Mar 2022

Understanding how coronavirus, RS virus and rhinovirus affect children

When Inger Heimdal started studying the coronavirus in children in 2014, not many people thought the topic sounded particularly exciting.

18 Mar 2022

Texas Biomed and UAB partnership uncovers a new, potent antibody cocktail against all coronaviruses

As SARS-CoV-2 has continued to evolve and outsmart existing treatments, scientists have not let up looking for ever-more effective tools to keep people safe and successfully recover from COVID-19, and to prepare for future outbreaks.

18 Mar 2022

Study reports thiopurines inhibit the replication of the betacoronaviruses HCoV-OC43 and SARS-CoV-2

Researchers demonstrated that the thiopurines block coronaviruses spike protein assembly and integration into progeny virions.

17 Mar 2022

Narrative review reports two important mediators in SARS-CoV-2-induced ischemic stroke recovery

Researchers explored neuroinflammation and COVID-19-induced ischemic stroke recovery.

17 Mar 2022

Identification of linear B cell epitopes in the SARS-CoV-2 proteome that are conserved in humans coronaviruses

Researchers identified and validated multiple linear B-cell epitopes in the SARS-CoV-2 proteomes conserved in humans coronaviruses.

15 Mar 2022

Exploring SARS-CoV-2 spike evolution in relation to sensitivity to antiviral restriction factors

Researchers investigated the effects of SARS-CoV-2 spike mutations on antiviral restriction mediated by interferon-induced transmembrane proteins and guanylate binding proteins.

11 Mar 2022

Potent pan-β-CoV human monoclonal antibody has in vivo activity in multiple animal models

Researchers evaluated the efficacy of viral spike domain 2-specific human monoclonal antibodies delivered intranasally, against all beta coronaviruses in hamsters and mice.

11 Mar 2022

Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

Researchers discovered and optimized cysteine-reactive pyrazoline-based covalent inhibitors for several coronaviruses' Mpro, including SARS-CoV-2.

11 Mar 2022

Individual-based model describing the transmission and spread of SARS-CoV-2 in the Belgian population

A recent study simulated the superspreading dynamics of COVID-19.

10 Mar 2022

Quantification of hydrophobic interactions encoded by FP1 sequences of SARS-CoV-2 and MERS-CoV by single-molecule force measurements

Researchers quantified hydrophobic interactions encoded by fusion peptide 1 sequences of SARS-CoV-2 and MERS-CoV using single-molecule force measurements.

10 Mar 2022

Study isolated largest panel of β-CoV broadly neutralizing antibodies to date

Researchers isolated a large panel of broadly neutralizing antibodies from COVID-19 recovered-vaccinated donors.

10 Mar 2022

The relationship between highly conserved residues in the SARS CoV fusion peptide and their role in coordinating calcium binding for viral entry

Researchers evidenced the significance of calcium in mediating the interaction between the coronaviruses fusion peptide and host cell membrane to provide insights into the mechanisms of viral entry.

9 Mar 2022

MERS CoV News and Research

Further Reading

Posaconazole found to be effective as a small molecule fusion inhibitor against SARS-CoV-2 variants

Study explores novel antiviral activity of PAD inhibitors against human beta-coronaviruses HCoV-OC43 and SARS-CoV-2

Multiple inter-variant recombination events identified in Omicron subvariants

Understanding how coronavirus, RS virus and rhinovirus affect children

Texas Biomed and UAB partnership uncovers a new, potent antibody cocktail against all coronaviruses

Study reports thiopurines inhibit the replication of the betacoronaviruses HCoV-OC43 and SARS-CoV-2

Narrative review reports two important mediators in SARS-CoV-2-induced ischemic stroke recovery

Identification of linear B cell epitopes in the SARS-CoV-2 proteome that are conserved in humans coronaviruses

Exploring SARS-CoV-2 spike evolution in relation to sensitivity to antiviral restriction factors

Potent pan-β-CoV human monoclonal antibody has in vivo activity in multiple animal models

Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

Individual-based model describing the transmission and spread of SARS-CoV-2 in the Belgian population

Quantification of hydrophobic interactions encoded by FP1 sequences of SARS-CoV-2 and MERS-CoV by single-molecule force measurements

Study isolated largest panel of β-CoV broadly neutralizing antibodies to date

The relationship between highly conserved residues in the SARS CoV fusion peptide and their role in coordinating calcium binding for viral entry

Increasing trend of antimicrobial resistance in Eastern Mediterranean Region of World Health Organization

Intragenomic rearrangements help explain how SARS-CoV-2 variants arise

A new view of SARS-CoV-2 genome structure

Scientists predict structure of SARS-CoV-2 frameshifting pseudoknot

Current progress in SARS-CoV-2 vaccine candidates

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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