Macrophage News and Research

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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

Researchers examine association between diabetes and obesity

It's by now well established that obesity is a major risk factor for diabetes. But what exactly is it about extra body fat that leads to insulin resistance and blood glucose elevation, the hallmarks of diabetes?

7 Mar 2014

Plymouth University doctor wins national award for animal testing alternative

Dr. Gyorgy Fejer from Plymouth University School of Biomedical and Healthcare Sciences has received a national award for his work developing the lab-based creation of a type of mouse cell line which could be used in place of live animals for research related to infectious diseases.

4 Mar 2014

New study shows increase in certain macrophages may lead to therapeutic targets for Crohn's disease

For those coping with Crohn's disease, a new research report published in the Journal of Leukocyte Biology offers hope for the development of new and more effective drugs. In the report, scientists show for the first time, precisely what type of immune cells are involved in driving the inflammation process in the disease.

4 Mar 2014

Blocking Netrin-1 in immune system stops chronic inflammation and insulin resistance tied to obesity

Researchers at NYU Langone Medical Center have found that blocking the action of a key signaling molecule in the immune system known as Netrin-1 stalls chronic inflammation and insulin resistance tied to obesity and often derived from fatty diets.

4 Mar 2014

Hypervirulent S. pneumoniae mutants discovered

Swedish researchers studying Streptococcus pneumoniae have discovered “hypervirulent” mutant forms of the bacteria that are selected for because they are more resistant to clearance by macrophages.

3 Mar 2014

Cognitive decline in obese diabetic mice can be reversed with regular exercise, surgical removal of belly fat

Cognitive decline that often accompanies obesity and diabetes can be reversed with regular exercise or surgical removal of belly fat, scientists report.

26 Feb 2014

Research grows "mini-livers" to reduce use of animals in science

Research that has for the first time successfully grown "mini-livers" from adult mouse stem cells has won the UK's international prize for the scientific and technological advance with the most potential to replace, reduce or refine the use of animals in science (the 3Rs).

26 Feb 2014

Cystinosis Research Foundation granted $2.15M in 2013 to researchers investigating cure for cystinosis

The Cystinosis Research Foundation awarded $2,153,048 in 2013 to researchers investigating better treatments and a cure for cystinosis, a rare metabolic and genetic disease that afflicts about 500 children and young adults in the United States and 2,000 worldwide.

19 Feb 2014

FDA approves CSC’s Phase II clinical trial for cancer immunotherapy in women with ovarian cancer

California Stem Cell, Inc. (CSC) announced today that the U.S. Food and Drug Administration (FDA) has approved the Company's application to begin a Phase II clinical trial exploring the potential of a patient-specific cancer immunotherapy in women with Stage III or IV ovarian, fallopian tube or primary peritoneal cancer.

19 Feb 2014

Some neurologic diseases associated with prenatal exposure to inflammatory immune responses

Johns Hopkins researchers report that fetal mice — especially males — show signs of brain damage that lasts into their adulthood when they are exposed in the womb to a maternal immune system kicked into high gear by a serious infection or other malady. The findings suggest that some neurologic diseases in humans could be similarly rooted in prenatal exposure to inflammatory immune responses.

7 Feb 2014

Research suggests that male mice may be vulnerable to effects of maternal inflammation than females

Johns Hopkins researchers report that fetal mice - especially males - show signs of brain damage that lasts into their adulthood when they are exposed in the womb to a maternal immune system kicked into high gear by a serious infection or other malady.

7 Feb 2014

ACE protein overexpression elevates immune responses and prevents Alzheimer's-like cognitive decline

Many people with high blood pressure are familiar with ACE inhibitors, drugs that widen blood vessels by limiting activity of ACE - angiotensin-converting enzyme - a naturally occurring protein found in tissues throughout the body.

4 Feb 2014

New study reveals way to combat drug-resistant tumors

Cancer drugs that recruit antibodies from the body's own immune system to help kill tumors have shown much promise in treating several types of cancer. However, after initial success, the tumors often return.

31 Jan 2014

Study demonstrates direct effects of fragmented sleep on tumor growth

Poor-quality sleep marked by frequent awakenings can speed cancer growth, increase tumor aggressiveness and dampen the immune system's ability to control or eradicate early cancers, according to a new study published online January 21, 2014, in the journal Cancer Research.

27 Jan 2014

Scientists showcase HDL nanotherapy that may provide solution to repeat heart attacks

Up to 30 percent of heart attack patients suffer a new heart attack because cardiologists are unable to control inflammation inside heart arteries - the process that leads to clots rupturing and causing myocardial infarction or stroke.

22 Jan 2014

New technology may provide solution to high risk of repeat heart attacks, say scientists

Up to 30 percent of heart attack patients suffer a new heart attack because cardiologists are unable to control inflammation inside heart arteries — the process that leads to clots rupturing and causing myocardial infarction or stroke.

20 Jan 2014

Researchers uncover how typhoid pathogen manages to evade host's immune system

The life-threatening disease typhoid fever results from the ongoing battle between the bacterial pathogen Salmonella and the immune cells of the body. Prof. Dirk Bumann's research group at the Biozentrum of the University of Basel has now uncovered how the typhoid pathogen repeatedly manages to evade the host's immune system. Their findings are published in the scientific journal "Cell Host & Microbe".

20 Jan 2014

Study shows high-fiber diet reduces risk of colon problems

Scientists have more reasons for you to eat fiber and not abuse antibiotics.

17 Jan 2014

Immune system plays important role in heart's response to injury

The immune system plays an important role in the heart's response to injury. But until recently, confusing data made it difficult to distinguish the immune factors that encourage the heart to heal following a heart attack, for example, from those that lead to further damage.

16 Jan 2014

UMMS researchers commissioned by Alpha-1 Project to develop PiZ antibody

Researchers at the University of Massachusetts Medical School (UMMS) have been commissioned by the Alpha-1 Project (TAP) to develop a PiZ antibody. The antibody will be used to track the presence of mutant alpha-1 PiZ protein in human blood serum, an essential tool in testing potential therapies for Alpha-1 Antitrypsin Deficiency (Alpha-1).

13 Jan 2014

Macrophage News and Research

Further Reading

Researchers examine association between diabetes and obesity

Plymouth University doctor wins national award for animal testing alternative

New study shows increase in certain macrophages may lead to therapeutic targets for Crohn's disease

Blocking Netrin-1 in immune system stops chronic inflammation and insulin resistance tied to obesity

Hypervirulent S. pneumoniae mutants discovered

Cognitive decline in obese diabetic mice can be reversed with regular exercise, surgical removal of belly fat

Research grows "mini-livers" to reduce use of animals in science

Cystinosis Research Foundation granted $2.15M in 2013 to researchers investigating cure for cystinosis

FDA approves CSC’s Phase II clinical trial for cancer immunotherapy in women with ovarian cancer

Some neurologic diseases associated with prenatal exposure to inflammatory immune responses

Research suggests that male mice may be vulnerable to effects of maternal inflammation than females

ACE protein overexpression elevates immune responses and prevents Alzheimer's-like cognitive decline

New study reveals way to combat drug-resistant tumors

Study demonstrates direct effects of fragmented sleep on tumor growth

Scientists showcase HDL nanotherapy that may provide solution to repeat heart attacks

New technology may provide solution to high risk of repeat heart attacks, say scientists

Researchers uncover how typhoid pathogen manages to evade host's immune system

Study shows high-fiber diet reduces risk of colon problems

Immune system plays important role in heart's response to injury

UMMS researchers commissioned by Alpha-1 Project to develop PiZ antibody

Microbiology eBook

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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