Major Depressive Disorder News and Research

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Major Depressive Disorder (MDD) is a psychiatric condition characterized by depressed mood or anhedonia (significant loss of interest or pleasure). The condition affects more than 15.7 million adults and approximately 3 million adolescents (aged 13 to 17 years) in the USA each year.

Researchers identify brain signatures for chronic pain in a small group of individuals

For the first time, researchers have recorded pain-related data from inside the brain of individuals with chronic pain disorders caused by stroke or amputation (phantom limb pain).

22 May 2023

Policy overhaul needed: Food industry's impact on global brain health

The dominance of the corporate-industrial food industry undermines brain capital and sustainable human development on a global scale. Understanding this impact is crucial for the future of public health and well-being.

17 May 2023

Study shows the power of gamma enhancement as potential approach for countering depression

Led by researchers from NYU Grossman School of Medicine and Hungary's University of Szeged, a new study in mice and rats found that restoring certain signals in a brain region that processes smells countered depression.

9 May 2023

Does physical activity impact substance use disorder treatment?

Researchers reviewed existing studies on physical activity interventions for treating substance use disorders.

28 Apr 2023

Genetic discovery may pave the way for precision medicine approaches to treat depression

A team of scientists at the Medical University of South Carolina (MUSC) has identified a stress-regulated gene that plays a role in the link between long-term stress and a common type of depressive behavior in mice.

7 Apr 2023

The intercommunication between the central nervous system and the digestive system and its contribution to mental health status

Researchers presented a comprehensive analysis of the correlation between gut microbiota and neurological as well as psychiatric disorders.

3 Apr 2023

Early life adversity linked to accelerated neurobiological aging, raising vulnerability to depression and Alzheimer's

scientists investigate the neurocognitive correlates of genetic vulnerability to major depressive disorder and Alzheimer's disease.

30 Mar 2023

Illness severity and clinical instability linked to risk of psychiatric hospitalization

For patients with psychiatric conditions, illness severity and instability are key factors in predicting future risk of hospitalization, according to a new study by Holmusk, a leading behavioral health real-world evidence and data analytics company, that has been published in The Lancet Psychiatry.

28 Mar 2023

Study highlights the role of intestinal T cells in modifying psychological stress responses

In experiments with mice and humans, a team led by Johns Hopkins Medicine researchers says it has identified a particular intestinal immune cell that impacts the gut microbiome, which in turn may affect brain functions linked to stress-induced disorders such as depression.

21 Mar 2023

Gut microbiomes and mental health: how do they interact?

A new study published in the journal Frontiers in Medicine reviewed recent literature on the link between gut microbiota, the brain, and neurological disorders.

19 Mar 2023

Using probiotics to treat depression

Researchers discuss whether probiotics could be used as supplementary or primary therapy to manage major depressive disorder.

15 Mar 2023

Personal use of psychedelics among therapists may be common, study finds

Whether personal use of psychedelics is appropriate among psychedelic therapists, a new study finds that it may be common.

27 Feb 2023

Study finds high prevalence of depression and anxiety in children and adolescents during COVID-19 pandemic

Recently, scientists sought to address this shortcoming and reviewed the existing literature to understand the indirect impact, on mental health, of strategies that were applied to restrict the spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection among children and adolescents.

23 Jan 2023

Did people use mental health services more during the COVID-19 pandemic?

Researchers explored the utilization rates of mental health services among adults during the coronavirus disease 2019 (COVID-19) pandemic.

11 Jan 2023

Scientists gain new insights into the opposing actions of serotonin-producing nerve fibers in mice

New insights into the opposing actions of serotonin-producing nerve fibers in mice could lead to drugs for treating addictions and major depression.

28 Dec 2022

Research shows promising results using neurotechnological approaches to treat youth depression

New research shows promising results using neurotechnological approaches to treat depression in youth. The research, led by Simon Fraser University (SFU) professor Faranak Farzan, is published in the Journal of Affective Disorders Reports.

1 Dec 2022

Multilevel Julich Brain Atlas could aid in studying psychiatric and aging disorders

The multilevel Julich Brain Atlas developed by researchers in the Human Brain Project, could help in studying psychiatric and aging disorders by correlating brain networks with their underlying anatomical structure.

16 Nov 2022

Full-metagenome analysis helps identify depressing gut microbe

In a three-year study, researchers from Skoltech, Vavilov Institute of General Genetics of RAS, the Moscow-based Mental-Health Clinic No. 1 Named After N.A. Alexeev and Serbsky Federal Medical Research Centre of Psychiatry and Narcology have examined how gut microbes in patients with a major depressive disorder are different from those in mentally healthy people.

15 Nov 2022

Repeated emotional stress in mice provokes irritable bowel syndrome-like symptoms

The evidence for the interconnection between emotional states and intestinal conditions has grown recently. These findings have led researchers to speculate about the association between the brain and the gut – the "gut-brain axis."

9 Nov 2022

Curbing depression among parents improves control of children's asthma, study finds

Depression and anxiety in the parents of children with asthma have been associated with increased clinic visits and asthma-related hospitalizations.

8 Nov 2022