Malignant News and Research

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Cancer requires support from immune system to develop, researchers report

Tumors that grow around nerves in a rare genetic disease need cooperation from cells from the immune system in order to grow, reports a team of scientists, including researchers from UT Southwestern Medical Center.

30 Oct 2008

Nanoparticles target multiple cancer genes, shrink tumors more effectively

Nanoparticles filled with small interfering RNA (siRNA) molecules targeting two genes that trigger melanoma have shown that they can inhibit the development of melanoma, the most dangerous type of skin cancer.

27 Oct 2008

Cell phones and brain cancer - major research initiatives needed

Major research initiatives are needed immediately to assess the possibility that using cellular phones may lead to an increased risk of brain tumors, according to an editorial in the November issue of the journal Surgical Neurology, published by Elsevier.

21 Oct 2008

Research suggests doctors should consider kidney-sparing surgery

A study of almost 1,500 kidney cancer patients treated at Memorial Sloan Kettering Cancer Center suggests that surgery to spare as much kidney tissue as possible may improve overall survival in patients who also have reduced kidney function at the time their cancer is diagnosed. The finding is significant because both kidney cancer and decreased kidney function appear to be increasing.

2 Oct 2008

Scientists identify a molecule that coordinates the movement of cells

Even cells commute. To get from their birthplace to their work site, they sequentially attach to and detach from an elaborate track of exceptionally strong proteins known as the extracellular matrix. Now, in research to appear in the October 3 issue of Cell, scientists at Rockefeller University show that a molecule, called ACF7, helps regulate and power this movement from the inside - findings that could have implications for understanding how cancer cells metastasize.

2 Oct 2008

Innovative technology to improve colon cancer prevention

Researchers at NorthShore University HealthSystem (NorthShore) and Northwestern University have discovered that fiber optic technology can for the very first time effectively measure blood levels in the colonic lining (mucosa) in humans, thus having potential applications for analyzing risk of colon cancer. The study appears in the October 2008 issue of Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.

30 Sep 2008

Targeted nanoparticles map tumor blood supply in 3-D, assess therapy

One of the defining characteristics of solid tumors is the development of a network of new blood vessels to nourish the rapidly reproducing malignant cells. Now, using a nanoparticle targeted to those new blood vessels, a joint academic-industrial research team, led by investigators from the Siteman Center of Cancer Nanotechnology Excellence, has developed a way to construct a three-dimensional (3-D) map of tumor-induced angiogenesis and monitor the effects of drug therapies on those new blood vessels.

28 Sep 2008

Social class dictates cancer risk

Cervical and lung cancer are more common in poor people while rates of breast cancer and melanoma are higher in the wealthy. A detailed analysis of the incidence of these four different kinds of cancer, carried out on more than 300,000 English cancer patients and published today in the open access journal BMC Cancer, describes the effects of socioeconomic group, region and age.

25 Sep 2008

Variations in cyclin D1 gene increase susceptibility to malignant melanoma

People who carry a particular genetic variant are at significantly increased risk of developing malignant melanoma, new research shows.

15 Sep 2008

A third of miscarriages preventable with steroid treatment

A conference in Liverpool in the UK has heard how some women who have suffered repeated miscarriages or failed IVF treatments may be helped to become mothers by taking a course of steroids.

10 Sep 2008

Researchers find cause of severe metabolic disorders

A healthy body stores fat in the form of so-called triglycerides in specialized fatty tissue as an energy reserve.

9 Sep 2008

Congressional Democrats will not vote on SCHIP expansion legislation this session amid veto threats, increased cost estimates

Congressional Democrats said they will not hold a vote on legislation to renew and expand SCHIP this year, citing an inability to override a promised veto by President Bush, among other issues, the New York Times reports.

9 Sep 2008

Celgene receives FDA 'fast track' for Amrubicin in small cell lung cancer after first-line chemotherapy

Celgene Corporation today announced that Amrubicin has been granted Fast Track product designation by the U.S. Food and Drug Administration (FDA) for the treatment of small cell lung cancer after first-line chemotherapy.

4 Sep 2008

Sports-related sudden cardiac death is reduced by pre-participation cardiovascular screening

Young competitive athletes are perceived by the general population to be the healthiest members of society. The possibility that highly trained athletes may have a potentially serious cardiac condition that can predispose to life-threatening tachyarrhythmias or sudden cardiac death seems paradoxical.

31 Aug 2008

Computed tomography provides anatomy - we need ischemia!

Cardiac computed tomography has revolutionized cardiac imaging in recent years by providing exquisitely detailed cardiac anatomy, including, but not limited to, coronary anatomy.

31 Aug 2008

Gleevec receives FDA priority review for gastrointestinal stromal tumors after surgery

Novartis has announced that Gleevec (imatinib mesylate) tablets, (known as Glivec (imatinib) outside the US, Canada and Israel), has been granted priority review status by the US Food and Drug Administration (FDA) as the first therapy to be reviewed for use after surgery in kit-positive gastrointestinal stromal tumors (GIST).

27 Aug 2008

New sickle cell unrelated transplant trial

Children's National Medical Center immunologist and blood and marrow transplant physician Naynesh Kamani, MD, will serve as the study co-chair for a new national clinical trial of unrelated donor marrow and umbilical cord blood transplants for severe sickle cell disease.

18 Aug 2008

Medulloblastoma in children - two studies find clues to treatment

Medulloblastoma is one of the most common and most malignant brain tumours among children and teenagers. These tumours grow very rapidly, and fifty percent of patients in the long term die from the condition. The details of the processes that lead to the growth of these tumours have remained unknown until now.

12 Aug 2008

Finding cancer's original cell key to treatments

Cancer biologists are turning their attention to the normal cells that give rise to cancers, to learn more about how tumor growth might be stopped at the earliest opportunity.

11 Aug 2008

Medulloblastoma originates in normal brain "stem" cells that turn malignant

An aggressive childhood brain tumor known as medulloblastoma originates in normal brain "stem" cells that turn malignant when acted on by a known mutant, cancer-causing oncogene, say researchers from Dana-Farber Cancer Institute and the University of California, San Francisco (UCSF).

11 Aug 2008