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Oncofetal ecosystems linked to recurrence and immunotherapy response in liver cancer

A team of clinician-scientists and researchers from the National Cancer Centre Singapore (NCCS), Agency for Science, Technology and Research (A*STAR), the Harry Perkins Institute of Medical Research and global research partners, has found a causal link between the presence of oncofetal ecosystems (re-emergence of fetal programme/features driven by the tumor) in the primary liver cancer hepatocellular carcinoma (HCC) and cancer recurrence and response to immunotherapy.

29 Jan 2024

European scientists target high-risk childhood cancer with liquid biopsy

Neuroblastoma mainly affects toddlers and young children - in the EU region there are 1500 new cases per year.

29 Jan 2024

Research upends understanding of circadian clock in melanoma

A Ludwig Cancer Research study has found that the circadian clock-;which synchronizes physiological and cellular activities with the day-night cycle and is generally thought to be tumor suppressive-;in fact has a contextually variable role in cancer.

27 Jan 2024

Missing NHS screenings linked to significantly higher breast cancer risk

Women who are diagnosed with ductal carcinoma in situ (DCIS) outside the NHS breast screening programme are around four times as likely to develop invasive breast cancer and to die from breast cancer than women in the general population, finds a study published by The BMJ today.

24 Jan 2024

Lung cancer prediction using biomarkers based on bronchoalveolar fluid microbiomes

The lung microbiomes of patients with benign and malignant pulmonary diseases.

23 Jan 2024

Patient-specific "organ-on-chip" aims to accelerate research on cholangiocarcinoma

It is only a few centimeters in size and can be held between two fingers, but in the micro-channels carved inside it, it's hidden a three-dimensional and highly faithful model of a biliary tract cancer called cholangiocarcinoma, complete with its tumor microenvironment.

22 Jan 2024

Early warning sign for myeloma found in bone marrow fat cells

A new research perspective was published in Oncotarget's Volume 15 on January 16, 2024, entitled, "Bone marrow adipocytes provide early sign for progression from MGUS to multiple myeloma."

22 Jan 2024

Non-destructive cancer grade probing system evaluates malignancy grade of model glioma cells

A water-soluble, luminescent europium complex enables evaluation of malignancy grade in model glioma tumor cells.

22 Jan 2024

Antiviral hope emerges as viruses linked to multiple myeloma

A few years ago, a patient was cured of multiple myeloma after being treated for hepatitis C, astounding researchers from the group led by Joaquín Martínez, from the H12O-CNIO Haematological Tumours Clinical Research Unit, a collaboration between the Hospital 12 de Octubre (H12O) and the National Cancer Research Centre (CNIO).

19 Jan 2024

Mathematical modeling demonstrates efficacy of combinational drug therapy for breast cancer treatment

Researchers use a mathematical model to assess the efficacy of a new combinational therapy of AZD9496 and palbociclib for breast cancer treatment.

18 Jan 2024

Revolutionary brain scan lights up glioma's Achilles heel

Recently, a team of South Korean researchers led by nuclear medicine physician and Professor Yun Mijin from Severance Hospital in collaboration with Director C. Justin LEE of the Center for Cognition and Sociality within the Institute for Basic Science (IBS) made a new discovery that can revolutionize both the diagnosis and treatment of glioblastoma.

16 Jan 2024

Scientists identify critical protein complex for targeted cancer treatment

The repair of damage to genetic material (DNA) in the human body is carried out by highly efficient mechanisms that have not yet been fully researched.

11 Jan 2024

Collaborative effort to develop AI-powered tools for glioma detection

Each year, about 22,000 individuals in the EU are diagnosed with a glioma, a malignant type of brain tumor. Median survival time after diagnosis can be as short as 15 months.

5 Jan 2024

Epilepsy drug may alleviate joint degeneration associated with osteoarthritis

A new study in Nature described Nav1.7 as a key regulatory molecule in cartilage cells and reported the effectiveness of Nav1.7 blockade in reducing pain and slowing progression in OA.

5 Jan 2024

COVID-19's unseen impact: study reveals surge in home deaths across 32 countries

Trends in places of death across 32 countries during and before the COVID-19.

5 Jan 2024

High-resolution map of the neuroblastoma immune landscape points to new target for immunotherapy

A detailed 'atlas' of neuroblastoma tumors points to a new target for immunotherapy. Scientists from the Princess Máxima Center for Pediatric Oncology in the Netherlands mapped this childhood tumor at the level of individual cancer and immune cells.

4 Jan 2024

HPV infection linked to doubled risk of thyroid cancer

A study in Taiwan involving 3,062 thyroid cancer patients and 9,186 controls finds that HPV infection more than doubles the risk of developing thyroid cancer, providing the first evidence of a carcinogen for this common endocrine cancer.

4 Jan 2024

Researchers establish the first international criteria for standardized imaging of gliomas

Diffuse gliomas are malignant brain tumors and cannot be optimally examined by conventional imaging using MRI. Amino acid PET can better visualize the activity and spread of gliomas.

3 Jan 2024

New standardized criteria for diagnosing brain tumors with amino acid PET

Diffuse gliomas are malignant brain tumors that cannot be optimally examined by means of conventional MRI imaging. So-called amino acid PET scans are better able to image the activity and spread of gliomas.

3 Jan 2024

GFH009 disrupts growth signals and triggers apoptosis in hematologic malignancies

A new research paper was published in Oncotarget's Volume 14 on December 20, 2023, entitled, "The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies."

28 Dec 2023

Malignant News and Research

Oncofetal ecosystems linked to recurrence and immunotherapy response in liver cancer

European scientists target high-risk childhood cancer with liquid biopsy

Research upends understanding of circadian clock in melanoma

Missing NHS screenings linked to significantly higher breast cancer risk

Lung cancer prediction using biomarkers based on bronchoalveolar fluid microbiomes

Patient-specific "organ-on-chip" aims to accelerate research on cholangiocarcinoma

Early warning sign for myeloma found in bone marrow fat cells

Non-destructive cancer grade probing system evaluates malignancy grade of model glioma cells

Antiviral hope emerges as viruses linked to multiple myeloma

Mathematical modeling demonstrates efficacy of combinational drug therapy for breast cancer treatment

Revolutionary brain scan lights up glioma's Achilles heel

Scientists identify critical protein complex for targeted cancer treatment

Collaborative effort to develop AI-powered tools for glioma detection

Epilepsy drug may alleviate joint degeneration associated with osteoarthritis

COVID-19's unseen impact: study reveals surge in home deaths across 32 countries

High-resolution map of the neuroblastoma immune landscape points to new target for immunotherapy

HPV infection linked to doubled risk of thyroid cancer

Researchers establish the first international criteria for standardized imaging of gliomas

New standardized criteria for diagnosing brain tumors with amino acid PET

GFH009 disrupts growth signals and triggers apoptosis in hematologic malignancies

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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