Malignant Hyperthermia News and Research

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Optically controlled local heat-pulse method manipulates temperature in cells

A team of researchers led by Osaka University finds that mutant variants of the calcium channel protein RyR1 are hypersensitive to heat, which creates a positive feedback loop of calcium release and leads to malignant hyperthermia

8 Aug 2022

Are you and your primary care doc ready to talk about your DNA?

If you have a genetic mutation that increases your risk for a treatable medical condition, would you want to know? For many people the answer is yes. But such information is not commonly part of routine primary care.

22 May 2018

Testing Service Members for Heat Related Illnesses Before Combat

It is common to think that combat deployment is the most dangerous part of being a warfighter, and in many ways this is correct. However, warfighters need to do many things before they are cleared to deploy to combat zones. Most cases of exertional heat illness (EHI) reported in the U.S. military occur during non-combat activities, such as training regimens, ruck marches, and operational exercises.

From Physitemp Instruments LLC 6 Sep 2017

Study shows link between susceptibility to malignant hyperthermia and exertional heat stroke

New research published online in The FASEB Journal may ultimately help athletes and trainers better understand who may be more at risk for heat stroke.

11 May 2017

Five ways to better prepare for planned or elective surgery

What's a tried-and-true way to prepare for surgery and anesthesia? By paying close attention to the healthcare professionals who will be delivering your care and providing them with essential information about your health status, history, and habits.

31 Mar 2017

Seven facts about malignant hyperthermia that can help avoid dangerous consequences during surgery

When general anesthesia is required for surgery or another procedure, a patient's care team must be ready for anything—especially the rare, life-threatening syndrome known as malignant hyperthermia.

13 Mar 2017

FDA approves Ryanodex for treatment of malignant hyperthermia linked with anesthesia

Eagle Pharmaceuticals, Inc. today announced the U. S. Food and Drug Administration (FDA) has approved Ryanodex® (dantrolene sodium) for injectable suspension indicated for the treatment of malignant hyperthermia (MH), along with the appropriate supportive measures.

24 Jul 2014

MedicAlert Foundation announces free medical IDs for individuals living with Malignant Hyperthermia

MedicAlert Foundation is pleased to announce that individuals living with Malignant Hyperthermia (MH) are now eligible to receive free medical IDs and live 24/7 emergency response services as the result of a grant obtained through the Sandi Ida Glickstein Fund at the Malignant Hyperthermia Association of the United States.

28 Jun 2014

Geoff Keller Group of MHAUS hosts fundraising event to promote MH awareness

The Geoffrey Keller Memorial Open Water Swim held in honor of the late son of Curt and Kathy Keller to raise funds to research better ways of managing Malignant Hyperthermia during surgery, to improve methods of detecting MH, and for MH awareness.

5 Jun 2014

Storing dantrolene can save 33 lives per year, say MH experts

MH experts say Storing dantrolene would save 33 lives per year at an incremental cost effectiveness ratio of nearly $200,000 (in 2010 dollars) per life saved, indicating that storing dantrolene at ambulatory surgical centers is very cost effective say, Malignant Hyperthermia Experts: Taiwo Aderibigbe, BS; Barbara H. Lang, BS; Henry Rosenberg, MD; Guohua Li, MD, PhD, Columbia University, New York who authored the article "Cost-Effectiveness Analysis of Stocking Dantrolene in Ambulatory Surgery Centers" that was recently published in the latest official journal of the American Society of Anesthesiologists, Anesthesiology.

5 Jun 2014

Patients with congenital disorders are urged to register with CMDIR to advance clinical trials

If you are affected by Malignant Hyperthermia, Congenital Muscular Dystrophies or Congenital Myopathy Subtypes, the Malignant Hyperthermia Association of the United States and the Cure Congenital Muscle Disease organization are asking for your help to enable research and clinical trials by registering with the Congenital Muscle Disease International Registry (CMDIR).

13 Mar 2014

Malignant Hyperthermia Scientific Conference to be held at University of Toronto

The 2013 Malignant Hyperthermia (MH) Scientific Conference is being held at the Chestnut Conference Centre, University of Toronto, Canada on November 1st and 2nd, 2013 and is sponsored by Malignant Hyperthermia Association of the United States (MHAUS) in conjunction with The University of Toronto.

29 Aug 2013

People exposed to hot environments may develop Malignant hyperthermia

There is mounting evidence that some people who are susceptible to Malignant hyperthermia (MH) will develop MH when exposed to hot environments or with exercise.

22 Aug 2013

Education about malignant hyperthermia is important to medical professionals and community

Orlando Health, the Florida Society of PeriAnesthesia Nurses, and the Florida Society of Anesthesiologists took a moment to comment on a conference they are co-sponsoring with the Malignant Hyperthermia Association of the United States in Orlando on June 29.

11 Jun 2013

Conference on Malignant Hyperthermia to be held in Orlando

Learn the basics on how recognize, diagnose, and treat Malignant Hyperthermia by attending at the "MH Let's Save a Life" conference where patients sit side by side with healthcare professionals, students, and families learning about MH from experts affiliated with MHAUS on June 8, 2013 from 10 am - 4 pm at Orlando Regional Medical Center located in Orlando, FL.

11 Apr 2013

Laryngopharyngeal surgery option for outpatients

Laryngopharyngeal surgeries that are performed in an ambulatory setting demonstrate low complication and admission rates, suggesting that such procedures can be carried out safely on an outpatient basis, show findings from a US study.

8 Jan 2013

Merck’s resubmission of the NDA for suggammadex sodium injection accepted for review by the FDA

Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the resubmission of the New Drug Application (NDA) for sugammadex sodium injection has been accepted for review by the U.S. Food and Drug Administration (FDA). Merck expects the FDA’s review to be completed in the first half of 2013.

7 Jan 2013

Dantrolene shows promise for treating DMD

A muscle relaxant called dantrolene used for treating malignant hyperthermia boosts the activity of therapies currently being developed to treat the genetic disorder Duchenne muscular dystrophy (DMD), show study findings.

17 Dec 2012

New video on how to handle Malignant Hyperthermia crisis now available from MHAUS

New video on how to handle a Malignant Hyperthermia crisis is now available from the Malignant Hyperthermia Association of the United States.

20 Oct 2012

Greater awareness of MH and consequences of ryanodine receptor gene mutations

From the MHAUS President's Blog by MHAUS President, Henry Rosenberg, MD. A few months ago, I received a call from the MH Hotline who connected me to an anesthesiologist and OR team who were desperately trying to manage a Malignant Hyperthermia crisis.

26 Jun 2012