Medulloblastoma News and Research

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ALSF announces grant award recipients of Crazy 8 Initiative in pediatric oncology

Alex's Lemonade Stand Foundation, a nonprofit foundation devoted to finding cures for all children with cancer, announces grant award recipients of their Crazy 8 Initiative.

16 Mar 2021

Discovery may help cancer patients to avoid chemotherapy's debilitating side effects

A discovery by University of Queensland pain researchers may allow some future cancer patients, including children with leukemia, to avoid their chemotherapy's worst and most debilitating side effects.

15 Mar 2021

Immune cells in cerebrospinal fluid could be novel biomarkers of response to immune-based therapies

Results from a study led by Joan Seoane, Director of Preclinical and Translational Research co-program at VHIO and ICREA Professor, show that immune cells accessing cerebrospinal fluid faithfully recapitulate the characteristics of cells identified in brain metastasis, and could therefore constitute novel biomarkers of response to immune-based therapies.

8 Mar 2021

New results challenge the current understanding of medulloblastoma

Scientists at St. Jude Children's Research Hospital and their colleagues have published a detailed account of SJMB03, a clinical trial for pediatric patients with medulloblastoma.

28 Jan 2021

Researchers discover a new approach to inhibit intrahepatic cholangiocarcinoma

Reprogramming the rich connective tissue microenvironment of a liver cancer known as intrahepatic cholangiocarcinoma (ICC) inhibits its progression and resistance to standard chemotherapy in animal models, researchers from Massachusetts General Hospital have found.

12 Jan 2021

Scientists develop a way to accurately detect and monitor common pediatric brain cancer

A team of scientists at Texas A&M University, Baylor College of Medicine and Texas Children's Hospital have developed a way to more accurately both detect and monitor a common type of pediatric brain cancer, setting the stage for giving clinicians a real-time view into how the cancer responds to treatment.

21 Oct 2020

Three new research teams aim to improve therapies for difficult-to-treat pediatric cancers

While incredible progress has been made in advancing pediatric cancer research, critical unmet needs still exist, especially for more aggressive cancers such as neuroblastomas and Ewing sarcoma.

19 Oct 2020

Researchers find way to make pediatric brain cancers respond better to therapies

Brain cancer in children is always a devastating diagnosis, but McMaster University researchers may have found a way to have the most serious types of pediatric brain cancer respond better to therapies.

28 Aug 2020

St. Jude scientists create O-PDX models for pediatric brain tumor research

Scientists at St. Jude Children's Research Hospital have created orthotopic patient-derived xenograft (O-PDX) models representing a variety of pediatric brain tumor types.

23 Jun 2020

Researchers report promising new therapy for recurrent pediatric brain cancers

Two pediatric brain cancers that are challenging to treat if they recur, medulloblastoma and ependymoma, are the target of a clinical trial using a new type of therapy.

27 Apr 2020

Hereditary genetic defect linked to medulloblastoma destabilizes protein regulation

The causes of 40 percent of all cases of certain medulloblastoma - dangerous brain tumors affecting children - are hereditary.

1 Apr 2020

Understanding hereditary medulloblastomas in children

This is a combined press release between EMBL, the Hopp Children's Cancer Center Heidelberg and the German Cancer Consortium.

1 Apr 2020

Inherited gene mutation can predispose children to SHH medulloblastoma

Investigators at St. Jude Children's Research Hospital, the European Molecular Biology Laboratory, and the German Cancer Research Center have identified ELP1 as a novel predisposition gene in the SHH subgroup of pediatric medulloblastoma.

1 Apr 2020

Surprising discovery about childhood brain tumor may unlock new cancer treatments

A surprising discovery about a rare form of childhood brain cancer suggests a new treatment approach for that cancer and, potentially, many others.

13 Feb 2020

Developing tests for genetic signs could lead to earlier cancer detection

Early signs of cancer can appear years before diagnosis and developing tests for these genetic signs could provide new ways to spot cancer early, according to new research led by the Crick and EMBL-EBI, and supported by an international cancer genomics consortium, the Pan-Cancer Analysis of Whole Genomes Project.

4 Feb 2020

New strategy using organoids to study childhood brain tumors

A new study reports the creation of in vitro models of brain tumors in children using organoids derived from stem cells, which will help to screen new drugs for efficacy and thus improve the rate of drug development. The study, titled 'Modeling medulloblastoma in vivo and with human cerebellar organoids,' is published in the journal Nature Communications.

29 Jan 2020

Researchers develop new strategy to study childhood brain tumors

Researchers are at work to find effective treatments to help young patients with brain tumors. Hundreds of brain organoids have been developed in the laboratories of the University of Trento to understand the genetic mechanisms responsible for these hard to treat diseases.

29 Jan 2020

Biodegradable nanoparticle can deliver 'suicide gene' to pediatric brain tumor cells in mice

Johns Hopkins researchers report that a type of biodegradable, lab-engineered nanoparticle they fashioned can successfully deliver a "suicide gene" to pediatric brain tumor cells implanted in the brains of mice.

8 Jan 2020

Extra DNA scooped up alongside cancer-causing genes helps drive tumor growth

One of the ways a cancer-causing gene works up enough power to turn a normal cell into a cancer cell is by copying itself over and over, like a Xerox machine.

21 Nov 2019

Fosun Pharma, MimiVax to jointly develop and commercialize SurVaxM therapy in U.S.

The inventors of a new and unique cancer immunotherapy developed at Roswell Park Comprehensive Cancer Center have announced a major step forward with that therapy, known as SurVaxM. MimiVax LLC principals Robert Fenstermaker, MD, and Michael Ciesielski, PhD, have announced that the company, spun off from Roswell Park in 2012, has entered into a China-exclusive licensing agreement for SurVaxM with Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd., a wholly-owned subsidiary of Shanghai Fosun Pharmaceutical Co. Ltd. based in Shanghai, China.

20 Nov 2019

Medulloblastoma News and Research

ALSF announces grant award recipients of Crazy 8 Initiative in pediatric oncology

Discovery may help cancer patients to avoid chemotherapy's debilitating side effects

Immune cells in cerebrospinal fluid could be novel biomarkers of response to immune-based therapies

New results challenge the current understanding of medulloblastoma

Researchers discover a new approach to inhibit intrahepatic cholangiocarcinoma

Scientists develop a way to accurately detect and monitor common pediatric brain cancer

Three new research teams aim to improve therapies for difficult-to-treat pediatric cancers

Researchers find way to make pediatric brain cancers respond better to therapies

St. Jude scientists create O-PDX models for pediatric brain tumor research

Researchers report promising new therapy for recurrent pediatric brain cancers

Hereditary genetic defect linked to medulloblastoma destabilizes protein regulation

Understanding hereditary medulloblastomas in children

Inherited gene mutation can predispose children to SHH medulloblastoma

Surprising discovery about childhood brain tumor may unlock new cancer treatments

Developing tests for genetic signs could lead to earlier cancer detection

New strategy using organoids to study childhood brain tumors

Researchers develop new strategy to study childhood brain tumors

Biodegradable nanoparticle can deliver 'suicide gene' to pediatric brain tumor cells in mice

Extra DNA scooped up alongside cancer-causing genes helps drive tumor growth

Fosun Pharma, MimiVax to jointly develop and commercialize SurVaxM therapy in U.S.

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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