Medulloblastoma News and Research

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New molecule can reduce aggressiveness of embryonal central nervous system tumors

In Brazil, scientists affiliated with the Human Genome and Stem Cell Research Center (HUG-CELL) at the University of São Paulo (USP) have identified a molecule capable of reducing the aggressiveness of embryonal central nervous system tumors.

7 Nov 2019

Researchers identify potential approach to stop growth of common brain tumor in children

University of North Carolina Lineberger Comprehensive Cancer Center researchers have identified a potential approach to stop the growth of the most common type of brain tumor in children.

24 Oct 2019

Novel cancer-driving mutation discovered in vast non-coding regions of the cancer genome

An Ontario-led research group has discovered a novel cancer-driving mutation in the vast non-coding regions of the human cancer genome, also known as the "dark matter" of human cancer DNA.

9 Oct 2019

Study receives NCI grant to explore better treatment for brain tumors in children

Children with recurrent brain tumors or newly diagnosed, particularly aggressive tumors called diffuse intrinsic pontine gliomas are being enrolled in the first study to examine the efficacy of a drug that inhibits an enzyme these tumors use to protect themselves from the child's natural immune response.

8 Oct 2019

Children's of Alabama using cold sore virus to fight pediatric brain cancer

Children's of Alabama is home to one of the most exciting studies underway in pediatric cancer: evaluating the use of a cold sore virus to treat children with progressive malignant brain tumors.

26 Sep 2019

Version of an antibiotic drug extends survival in mice with lethal pediatric brain tumors

Versions of an antibiotic drug called DON first isolated from soil bacteria more than 60 years ago have shown promising signs of extending survival in mice models of especially lethal pediatric brain tumors marked by the high expression of a cancer-causing gene known as the MYC oncogene, according to results of two studies from researchers at the Johns Hopkins Kimmel Cancer Center.

23 Sep 2019

Leukemia drug appears to be effective in treating deadly pediatric brain tumor

A drug used to treat chronic myeloid leukemia appears to be more effective at stopping a type of medulloblastoma in mouse models than existing treatments for the deadly pediatric brain tumor, reports a multi-institutional team led by researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego.

21 Sep 2019

New biomarkers help predict response to treatment in common brain tumor

Many scientists have noted that there is a link between inflammation or the immune response, and patient survival. One such possible relationship is the association of blood markers and the prognosis in the brain tumor called medulloblastoma.

16 Sep 2019

Scientists identify molecule that plays key role in determining fate of cells under stress

St. Jude Children's Research Hospital scientists have identified a molecule that plays a pivotal role in determining the fate of cells under stress, much like a Roman emperor deciding the fate of gladiators in the coliseum.

12 Sep 2019

Cracking the code of a recurrent brain cancer

One of the most common brain cancers in children, Sonic Hedgehog (SHH) medulloblastoma, also is one of the more survivable for most kids. Unfortunately, for a subset of patients the cancer resists treatment and relapses with a vengeance to then turn deadly.

30 Aug 2019

Research links inherited BRCA2 mutations with increased risk of childhood lymphoma

A report from St. Jude Children's Research Hospital links inherited mutations in the BRCA2 gene with an increased risk of developing non-Hodgkin lymphoma in children and adolescents.

25 Jul 2019

Researchers turn to single-cell analysis to understand a pediatric brain tumor

Investigators at St. Jude Children's Research Hospital and Massachusetts General Hospital, alongside others, have revealed the cells of origin for specific subtypes of medulloblastoma, the most common malignant pediatric brain tumor.

25 Jul 2019

Four young scientists receives Damon Runyon-Sohn Pediatric Cancer Fellowship Award

The Damon Runyon Cancer Research Foundation has named four outstanding young scientists as recipients of the prestigious Damon Runyon-Sohn Pediatric Cancer Fellowship Award, committing nearly $1 million to help address a critical shortage of funding for pediatric cancer research.

17 Jul 2019

Research identifies super-enhancers as novel target for pancreatic ductal adenocarcinoma

Differential H3K27AC marks were identified at enhancer regions of genes including c-MYC, MED1, OCT-4, NANOG, and SOX2 that can act as super-enhancers (SE), cluster of genes in non-cancerous, cancerous and metastatic PDAC cell lines.

1 Mar 2019

FSU study breaks new ground in the battle against malignant pediatric brain cancers

Scientists are making important progress in the battle against a class of devilishly complex human pediatric brain cancers thanks to a new study from a team of Florida State University students and faculty.

30 Jan 2019

Nine early career scientists named 2019 recipients of the Damon Runyon-Rachleff Innovation Award

The Damon Runyon Cancer Research Foundation announced that nine scientists with novel approaches to fighting cancer have been named 2019 recipients of the Damon Runyon-Rachleff Innovation Award.

24 Jan 2019

Researchers find new tiny molecule that is capable of killing medulloblastoma

A new study by UT Health San Antonio researchers found that a molecule thousands of times smaller than a gene is able to kill medulloblastoma, the most common childhood brain cancer.

8 Nov 2018

Scientists identify more aggressive chemotherapy treatment for childhood brain cancer

Scientists led by Newcastle University have been able to identify the group of children needing more intensive, aggressive chemotherapy treatment for the most common form of brain cancer.

2 Nov 2018

Research holds promise for treatment of pediatric brain cancer

New research published in Nature Communications from scientists at Huntsman Cancer Institute at the University of Utah, in collaboration with the Stanford University School of Medicine, shows a specific protein regulates both the initiation of cancer spreading and the self-renewal of cancer cells in medulloblastoma, a type of pediatric brain cancer.

12 Oct 2018

TGen and PNOC take part in launch of NIH-supported Kids First Data Resource Portal

As part of a national initiative to solve children's diseases, the Translational Genomics Research Institute and the Pacific Pediatric Neuro-Oncology Consortium are participating in the launch of the Kids First Data Resource Portal, which is supported by the National Institutes of Health .

19 Sep 2018