Melanoma Cells News and Research

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Blocking BRAF ubiquitination may be an effective treatment approach in melanoma

The protein BRAF is a key player in the development of many different types of cancer, including melanoma.

24 Apr 2019

Hole-forming protein could help control cancer growth

Sometimes cells need to die. The process of cell death is encoded within the genome of all higher organisms to kill off cancerous cells, and as a normal part of development to shape a mass of embryonic cells into the organism it will become.

22 Apr 2019

Researchers uncover cellular resistance mechanisms to BRAF inhibitors in melanoma

Melanoma is one of the most aggressive types of skin cancer, but recent advances in targeted therapies have improved the prognosis for many patients. Unfortunately, for some patients these positive outcomes are not long lasting, due to the development of drug resistance and tumor recurrence.

15 Apr 2019

Scientists discover central role of cell 'skeleton'

All cells possess a cytoskeleton which allows them to move and maintain their shape. However, scientists recently showed that a part of this cytoskeleton called branched actin is also essential to cell proliferation: this actin transmits information to cells about the space around them, environmental chemical messages and therefore on whether they should proliferate.

10 Apr 2019

BU researchers identify biomarker and possible new therapy for melanoma

Researchers have identified a biomarker and a possible new therapy for melanoma.

26 Mar 2019

Bacteria from seawater provide new leads to treat malignant melanoma

Malignant melanoma can be a particularly dangerous form of cancer, and more therapeutic options are needed. Now, researchers report in ACS Medicinal Chemistry Letters that a bacteria from seawater has inspired promising leads for an entirely new way to treat the disease.

7 Mar 2019

Groundbreaking AI technology could predict melanoma metastasis

An interdisciplinary team of researchers at Ben-Gurion University of the Negev in Israel and the University of Texas Southwestern Medical Center in Dallas have developed groundbreaking technology to identify melanoma cells that are likely to metastasize to other parts of the body using artificial intelligence.

26 Feb 2019

New forms of older anti-cancer agent appear to enhance immune response to fight melanoma

Researchers at the Bloomberg~Kimmel Institute for Cancer Immunotherapy at Johns Hopkins and the Johns Hopkins University School of Medicine report two new forms of an older anti-cancer agent they developed appear to enhance the immune system's ability to fight melanoma in mice.

20 Feb 2019

Study shows how skin cancer hijacks the immune system to grow and spread

Scientists have uncovered molecules released by invasive skin cancer that reprogram healthy immune cells to help the cancer to spread.

31 Jan 2019

Injection of genetically modified virus effectively treats metastatic melanoma patients

Injection of a genetically modified virus that induces the body's own immune cells to attack metastatic melanoma effectively treated almost 40 percent of patients with tumors that could not be surgically removed, according to researchers from three prominent cancer centers in a study published as an "article in press" on the Journal of the American College of Surgeons website in advance of print publication.

28 Jan 2019

Ludwig researchers find ways to make resistant melanomas susceptible to immunotherapy

A Ludwig Cancer Research study has uncovered a cellular mechanism by which melanomas that fail to respond to checkpoint blockade may be made susceptible to such immunotherapies.

23 Jan 2019

FDA-approved drug hampers cancer metastasis in animal model, shows study

For cancer to spread, it needs a hospitable environment in distant organs. This fertile "soil" can provide a home to circulating malignant cells.

16 Jan 2019

Melanoma cells put to sleep by T cells improving outcomes, find researchers

Australian researchers have found that special immune cells of the body not only protect us from the invading bacteria, viruses and microbes but also play a role in reducing the aggressiveness of the melanoma cells.

1 Jan 2019

Researchers discover how MAPK translocation leads to drug resistance in melanoma

Researchers have discovered that the ER translocation of MAPK leads to drug resistance in melanoma.

18 Dec 2018

New drug combination could kill melanoma cells more effectively, study shows

A class of cancer drugs called protein kinase inhibitors is one of the most effective treatments for melanoma. However, in many cases, tumors eventually become resistant to the drugs and cause a relapse in the patient.

3 Dec 2018

Using molecular targeting approach to kill melanoma cells

In 1960, scientists described the "Philadelphia chromosome" that causes chronic myeloid leukemia, and in 2001 the Food and Drug Administration approved the drug imatinib to disable the action of this cancer-causing genetic change.

27 Nov 2018

New City of Hope CAR T cell trial focuses on HER2-positive breast cancer patients with brain metastases

Women with HER2-positive breast cancer that has spread to the brain need more treatment options, and City of Hope and Mustang Bio Inc. are meeting that challenge.

30 Oct 2018

Study suggests new strategy to kill melanoma cells

Think of the protein BH3 like a finger that turns off a cancer cell survival switch. The problem is that most cancer cells have found ways to remove this "finger" - commonly, by breaking the action of a gene called p53 that puts the BH3 finger in motion. Now think of Bcl-2 as the switch itself.

24 Oct 2018

Study unravels how cancer stem cells use normal genes in abnormal ways

CDK1 is a "normal" protein - its presence drives cells through the cycle of replication. And MHC Class I molecules are "normal" as well - they present bits of proteins on the surfaces of cells for examination by the immune system.

15 Oct 2018

Changes in skin and lymphatic system due to age facilitate melanoma metastasis

Changes in the structure of the skin and the lymphatic system that occur with the natural aging process create permissive conditions for melanoma metastasis, according to two studies by The Wistar Institute.

3 Oct 2018