Melatonin News and Research

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Melatonin, also known chemically as N-acetyl-5-methoxytryptamine, is a naturally occurring compound found in animals, plants, and microbes. In animals, circulating levels of the hormone melatonin vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions.

From fatigued to fantastic! You CAN effectively treat CFS, fatigue, fibromyalgia and muscle pain

The “perfect storm” for Fibromyalgia, CFS/ME, and fatigue in general is preparing to hit. A combination of poor nutrition, decreasing sleep, increasing stress and environmental toxins has created a human energy crisis of unprecedented proportions. Over the past 10 years, the incidence of Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FMS) has exploded by 400 to 1000 percent, as documented in five separate studies. The numbers for those with CFS in the U.S., previously estimated at 500,000, are now being re-tallied at closer to 1- 2.5 million. Previous estimates placed the number of Americans with FMS at 6 million. Studies worldwide suggest this has likely gone up in the last decade to ~ 12-24 million Americans! Meanwhile, ¼ of Americans suffer with chronic pain and most are fatigued.

28 Mar 2011

LRC professors develop daylighting design guide for school students

The body's internal clock is responsible for regulating the timing of our sleep and other daily biological cycles, called circadian rhythms. During school months, however, teenagers miss out on essential morning light needed to stimulate the 24-hour biological clock.

15 Mar 2011

Poll explores link between Americans' use of communication technologies and sleep habits

The 2011 Sleep in America- poll released today by the National Sleep Foundation finds pervasive use of communications technology in the hour before bed. It also finds that a significant number of Americans aren't getting the sleep they say they need and are searching for ways to cope.

7 Mar 2011

Night shift work may reduce risk of skin cancer in women

Melatonin is known to have cancer-protective properties, and shift work can induce desynchrony of the circadian system, reducing melatonin production. Shift work has been thought to have important health impacts, with evidence linking shift work to an increased risk of several cancers including breast, endometrial, prostate, and colorectal, and non-Hodgkin lymphoma.

2 Mar 2011

Study finds link between sleep duration and colorectal adenomas

An inadequate amount of sleep has been associated with higher risks of obesity, heart disease, diabetes, and death. Now colon cancer can be added to the list.

9 Feb 2011

Study suggests human amniotic cells 'cross talk' with melatonin receptor MT1

Human amniotic epithelial cells, stem cells derived from human placenta left over from live births and generally discarded, proliferated and differentiated when they interacted with one kind of melatonin receptor, MT1. This potentially therapeutic response occurred when the stem cells were transplanted into laboratory test tube and animal models of stroke. The same cells did not perform similarly when interacting with melatonin receptor MT2.

2 Feb 2011

Exposure to room light prior to bedtime suppresses melatonin levels, increases cancer and diabetes risk: Study

According to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism, exposure to electrical light between dusk and bedtime strongly suppresses melatonin levels and may impact physiologic processes regulated by melatonin signaling, such as sleepiness, thermoregulation, blood pressure and glucose homeostasis.

13 Jan 2011

Chronic jet lag alters brain's intricate role in memory processing

Chronic jet lag alters the brain in ways that cause memory and learning problems long after one's return to a regular 24-hour schedule, according to research by University of California, Berkeley, psychologists.

25 Nov 2010

Inexpensive intervention helps patients with hypertension-associated kidney disease

In patients with kidney disease, the Western diet produces an acidic environment in the body that has numerous negative effects and worsens with age as kidney function declines.

21 Nov 2010

Dim light at night linked to depression

Exposure to even dim light at night is enough to cause physical changes in the brains of hamsters that may be associated with depression, a new study shows.

18 Nov 2010

Depression associated with molecular-level disturbance in body's 24-hour clock

Depression appears to be associated with a molecular-level disturbance in the body's 24-hour clock, new research suggests.

11 Nov 2010

Persistent exposure to light at night leads to weight gain

Persistent exposure to light at night may lead to weight gain, even without changing physical activity or eating more food, according to new research in mice.

12 Oct 2010

Hormone melatonin improves egg quality in IVF

Poor egg (oocyte) quality is an important cause of female infertility. Low quality eggs may have several problems, for example they may not divide properly, or they may be missing certain chromosomes. Egg quality also declines with age, and certain medical conditions, such as PolyCystic Ovary Syndrome, can lead to poor quality eggs.

15 Sep 2010

New study finds additional link between Light At Night and cancer

A new study from the Center for Interdisciplinary Chronobiological Research at the University of Haifa has found an additional link between Light At Night (LAN) and cancer. This research joins a series of earlier studies carried out at the University of Haifa that also established the correlation. "High power light bulbs contribute more to 'environmental light pollution', which the study has shown is a carcinogenic pollution," notes Prof. Abraham Haim, who headed the study.

3 Sep 2010

Lack of sleep linked to depression and anxiety disorders in young

According to Australian research, youngsters getting inadequate sleep are at risk of mental ailments. Researcher Nicholas Glozier of the University of Sydney said, the increase in incidence of mental ailments in the young has been puzzling health experts. The answer may lie in inadequate sleep.

2 Sep 2010

23rd ECNP Press conference on impact of circadian rhythms on human brain

All humans are synchronised to the rhythmic light-dark changes that occur on a daily basis. Rhythms in physiological and biochemical processes and behavioural patterns persist in the absence of all external 24-hour signals from the physical environment, with a period that is close to 24 hours

30 Aug 2010

Vanda Pharmaceuticals initiates tasimelteon Phase III clinical trial for Non-24-Hour Sleep Wake Disorder

Vanda Pharmaceuticals Inc., today announced it has initiated a Phase III clinical trial to evaluate tasimelteon in patients with Non-24-Hour Sleep Wake Disorder (N24HSWD), a condition experienced primarily by totally blind individuals that results in abnormal night sleep patterns and chronic daytime sleepiness.

26 Aug 2010

Later sunset, extended daylight exposure delays bedtimes in teenagers

In the spring, later sunset and extended daylight exposure delay bedtimes in teenagers, according to researchers at Rensselaer Polytechnic Institute's Lighting Research Center (LRC).Biologically, this increased exposure to early evening light in the spring delays the onset of nocturnal melatonin, a hormone that indicates to the body when it's nighttime, explains Mariana Figueiro, Ph.D., associate professor. This extended exposure adds to the difficulties teens have falling asleep at a reasonable hour.

27 Jul 2010

Impact of circadian dysregulation on mental, physical health

Circadian (daily) rhythms are found in all functions - e.g. performance, mood, endocrine rhythms, behaviour, sleep timing. The biological clocks that control circadian rhythms are based on a genetic programme of interacting molecules in cells throughout the body, coordinated by a ´master clock´ in the brain and synchronised by external cues, mainly light.

16 Jul 2010

Tart cherry juice could help reduce severity of insomnia in older adults: Study

Drinking tart cherry juice daily could help reduce the severity of insomnia and time spent awake after going to sleep, according to a new study published in the Journal of Medicinal Food.

13 Jul 2010