Metabolic Disease News and Research

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Calchan, Galapagos partner to discover and develop novel target for osteoarthritic pain

Calchan Holdings Limited, a UK company focused on the development of novel medicines based on calcium ion channel modulators, and Galapagos NV, a clinical stage biotech company focused on developing novel mode of action medicines, today announce that they have entered into a research collaboration in the area of osteoarthritis pain.

27 Oct 2014

Crown Bioscience announces U.S. expansion with new translational oncology center

Crown Bioscience, Inc., a leading global drug discovery and development service company, has announced the opening of the Crown Bioscience US Research Center to be located at the David H. Murdock Research Institute (DHMRI), in Kannapolis, N.C. The new center, which will open in the 3rd quarter of 2014, represents significant U.S. market expansion for Crown.

21 Oct 2014

Discovery offers promising new avenue for prevention, treatment of type 2 diabetes

The surprising discovery of a previously unidentified class of lipid molecules that enhance insulin sensitivity and blood sugar control offers a promising new avenue for the prevention and treatment of type 2 diabetes.

10 Oct 2014

EnteroMedics' CE Mark for Maestro System expanded to include management of Type 2 diabetes mellitus

EnteroMedics Inc., the developer of medical devices using neuroblocking technology to treat obesity, metabolic diseases and other gastrointestinal disorders, today announced that its CE Mark for the Maestro Rechargeable (RC) System for obesity was expanded to include the management of Type 2 diabetes mellitus through improved glycemic control.

29 Sep 2014

NCCN ORP awards four research grants to advance development of nintedanib

The National Comprehensive Cancer Network Oncology Research Program has awarded four grants to investigators to evaluate and define the clinical effectiveness of the investigational compound nintedanib (BIBF 1120) in non-small cell lung, colorectal, and gastrointestinal cancers.

25 Sep 2014

FDA approves Contrave extended-release tablets for chronic weight management

Takeda Pharmaceuticals U.S.A., Inc. and Orexigen® Therapeutics, Inc. jointly announced today that the U.S. Food and Drug Administration has approved Contrave® extended-release tablets as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index of 30 kg/m2 or greater (obese), or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition.

11 Sep 2014

5-minute walks can reverse harm caused to leg arteries from prolonged sitting

An Indiana University study has found that three easy -- one could even say slow -- 5-minute walks can reverse harm caused to leg arteries during three hours of prolonged sitting.

9 Sep 2014

Case Western Reserve scientists discover leaky gut as source of non-AIDS complications

Human immunodeficiency virus (HIV) infection is no longer a fatal condition, thanks to newer medications inhibiting the retrovirus, but a puzzling phenomenon has surfaced among these patients — non-AIDS complications. Scientists at Case Western Reserve University School of Medicine have resolved the mystery with their discovery of the leaky gut as the offender.

4 Sep 2014

Ethicon unveils three new devices at IFSO 2014 to address unique challenges of bariatric procedures

Ethicon is introducing three new endocutter and energy products designed to help address the unique challenges of bariatric procedures such as sleeve gastrectomy and gastric bypass.

27 Aug 2014

Study shows castor bean oil reduces epileptic seizures related to Glut1 deficiency

Two years ago, the parents of Chloe Olivarez watched painfully as their daughter experienced epileptic seizures hundreds of times a day.

12 Aug 2014

New mechanism of joint destruction grinds away healthy cartilage, worsens osteoarthritis

A new mechanism of joint destruction caused by a natural material that grinds away healthy cartilage and worsens osteoarthritis has been identified in human hip joints for the first time by University of Liverpool scientists.

12 Aug 2014

New hope for people suffering from obesity and diabetes

White, brown and beige adipocytes, or fat cells, are inherently different. Each of these cell types has different functions and each plays its own role in metabolism. In the human body, white adipose tissue is by far the most prevalent.

31 Jul 2014

Findings underscore the importance of prenatal health care, postnatal breastfeeding

Young adults who were breastfed for three months or more as babies have a significantly lower risk of chronic inflammation associated with cardiovascular and metabolic diseases, according to research from the Brown School at Washington University in St. Louis.

31 Jul 2014

Mice exposed to fungicide tolyfluanid show metabolic changes

Mice exposed to the fungicide tolyfluanid (TF) showed metabolic changes similar to those that signify the development of the metabolic syndrome. The results, which were presented Sunday at the joint meeting of the International Society of Endocrinology and the Endocrine Society: ICE/ENDO 2014 in Chicago.

24 Jun 2014

Study of SLC13 transporters unlocks their therapeutic potential

Researchers have provided the first functional analysis of a member of a family of transporter proteins implicated in diabetes, obesity, and lifespan. The study appears in the June issue of The Journal of General Physiology.

19 Jun 2014

Healthy inflammation necessary to prevent metabolic diseases, study finds

Chronic tissue inflammation is typically associated with obesity and metabolic disease, but new research from UT-Southwestern Medical Center now finds that a level of "healthy" inflammation is necessary to prevent metabolic diseases, such as fatty liver.

19 Jun 2014

Medison to market uniQure's Glybera in Israel for treatment of lipoprotein lipase deficiency

uniQure N.V., a leader in human gene therapy, and Medison Pharma Ltd., Israel's leading international healthcare marketing group, today announced an exclusive distribution agreement under which Medison will market Glybera, uniQure's gene therapy product for the treatment of lipoprotein lipase deficiency (LPLD), in Israel and the Palestinian Authority.

18 Jun 2014

Wayne State researchers to study how exposures to stressors impact human health in Detroit

With over $2.4 million in new federal funding, Wayne State University researchers, regional collaborators at Henry Ford Health System, the University of Michigan and Michigan State University, and community partners will study how exposures to stressors that are prevalent in the urban industrialized environment — both chemical and non-chemical — impact human health in Detroit and beyond.

18 Jun 2014

Single dose restores normal cellular signaling in mouse model of autism

In a further test of a novel theory that suggests autism is the consequence of abnormal cell communication, researchers at the University of California, San Diego School of Medicine report that an almost century-old drug approved for treating sleeping sickness also restores normal cellular signaling in a mouse model of autism, reversing symptoms of the neurological disorder in animals that were the human biological age equivalent of 30 years old.

18 Jun 2014

KineMed renews non-exclusive research collaboration with Pfizer

KineMed Inc. today announced the renewal of a non-exclusive research collaboration with Pfizer Inc. for the advancement of novel approaches in metabolic disease, in particular Type II diabetes.

4 Jun 2014

Metabolic Disease News and Research

Calchan, Galapagos partner to discover and develop novel target for osteoarthritic pain

Crown Bioscience announces U.S. expansion with new translational oncology center

Discovery offers promising new avenue for prevention, treatment of type 2 diabetes

EnteroMedics' CE Mark for Maestro System expanded to include management of Type 2 diabetes mellitus

NCCN ORP awards four research grants to advance development of nintedanib

FDA approves Contrave extended-release tablets for chronic weight management

5-minute walks can reverse harm caused to leg arteries from prolonged sitting

Case Western Reserve scientists discover leaky gut as source of non-AIDS complications

Ethicon unveils three new devices at IFSO 2014 to address unique challenges of bariatric procedures

Study shows castor bean oil reduces epileptic seizures related to Glut1 deficiency

New mechanism of joint destruction grinds away healthy cartilage, worsens osteoarthritis

New hope for people suffering from obesity and diabetes

Findings underscore the importance of prenatal health care, postnatal breastfeeding

Mice exposed to fungicide tolyfluanid show metabolic changes

Study of SLC13 transporters unlocks their therapeutic potential

Healthy inflammation necessary to prevent metabolic diseases, study finds

Medison to market uniQure's Glybera in Israel for treatment of lipoprotein lipase deficiency

Wayne State researchers to study how exposures to stressors impact human health in Detroit

Single dose restores normal cellular signaling in mouse model of autism

KineMed renews non-exclusive research collaboration with Pfizer

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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