Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

Study opens door for development of tools to modulate CoQ10 synthesis in human cells

A study which counts with the participation of University of Granada scientists has provided new data on the Q10 coenzyme (CoQ10), a molecule which is synthesized within the cells of the organism itself and which has essential functions for cellular metabolism.

4 Feb 2015

Study: Common pesticide may alter the development of brain's dopamine system

A commonly used pesticide may alter the development of the brain's dopamine system -- responsible for emotional expression and cognitive function - and increase the risk of attention deficit hyperactivity disorder in children, according to a new Rutgers study.

30 Jan 2015

New experimental study shows immunotherapy can reduce acute effects of heroin

Immunotherapy could have a place in the treatment of substance abuse in the future. A specific antibody can reduce the acute effects of heroin, according to a new experimental study at the Norwegian Institute of Public Health.

21 Jan 2015

Study: Century-old drug may help treat autism

Autism spectrum disorders (ASD) affect 1 to 2 percent of children in the United States. Hundreds of genetic and environmental factors have been shown to increase the risk of ASD. Researchers at UC San Diego School of Medicine previously reported that a drug used for almost a century to treat trypanosomiasis, or sleeping sickness, reversed environmental autism-like symptoms in mice.

16 Jan 2015

UCSD nanoengineers develop temporary tattoo to measure glucose levels

Nanoengineers at the University of California, San Diego have tested a temporary tattoo that both extracts and measures the level of glucose in the fluid in between skin cells. This first-ever example of the flexible, easy-to-wear device could be a promising step forward in noninvasive glucose testing for patients with diabetes.

15 Jan 2015

How quickly smokers metabolise nicotine may point to best quitting method

The success of different smoking cessation treatments could be predicted by how quickly smokers break down (metabolise) nicotine in their bodies, according to new research published in The Lancet Respiratory Medicine journal.

13 Jan 2015

Tobacco smoke toxin could increase pain in people with spinal cord injury

A neurotoxin called acrolein found in tobacco smoke that is thought to increase pain in people with spinal cord injury has now been shown to accumulate in mice exposed to the equivalent of 12 cigarettes daily over a short time period.

4 Dec 2014

New drug shows promise against treatment-resistant non-small cell lung cancer

A new drug that targets not only common cancer-causing genetic mutations in patients with non-small cell lung cancer (NSCLC), but also a form of the mutation that causes resistance to treatment, has shown promising results in patients in a phase I/II clinical trial.

23 Nov 2014

Scientists discover ways to detect several toxic flame retardants in people's bodies

A new peer-reviewed study found that people are contaminated with several toxic flame retardants rarely studied in the US, including one that has never before been detected in Americans called TCEP. Scientists tested urine samples of California residents for biomarkers of six chemicals, all of which were present.

13 Nov 2014

Changes in cell metabolism slow growth of colorectal cancer

Cancer is an unwanted experiment in progress. As the disease advances, tumor cells accumulate mutations, eventually arriving at ones that give them the insidious power to grow uncontrollably and spread. Distinguishing drivers of cancer from benign mutations open opportunities for developing targeted cancer therapies.

30 Oct 2014

Prenatal exposure to phthalate DiNP associated with shorter AGD in Swedish boys: Study

The first study to examine prenatal exposure to the phthalate DiNP finds it is associated with a shorter anogenital distance (AGD) in Swedish boys at the age of 21 months. These findings raise concern since animal research has linked DiNP exposure to a shorter AGD, and studies on humans have related shorter AGD to male genital birth defects as well as impaired reproductive function in adult males, and the levels of DiNP metabolites in humans are increasing globally.

30 Oct 2014

Autism Speaks grants $1M to Children's Hospital Los Angeles to improve GI symptoms associated with ASD

Pat Levitt, PhD, Simms/Mann Chair in Developmental Neurogenetics at Children's Hospital Los Angeles, has received a grant of nearly $1 million from Autism Speaks, the world's leading autism science and advocacy organization.

24 Oct 2014

Novel approach may help detect invasive aspergillosis

Many different microbes can cause pneumonia, and treatment may be delayed or off target if doctors cannot tell which bug is the culprit. A novel approach—analyzing a patient's breath for key chemical compounds made by the infecting microbe—may help detect invasive aspergillosis, a fungal infection that is a leading cause of mortality in patients with compromised immune systems, according to a proof-of-concept study now online in Clinical Infectious Diseases.

23 Oct 2014

Eating high-protein breakfast reduces food cravings, overeating later on

According to the Centers for Disease Control and Prevention, many teens skip breakfast, which increases their likelihood of overeating and eventual weight gain. Statistics show that the number of adolescents struggling with obesity, which elevates the risk for chronic health problems, has quadrupled in the past three decades.

16 Oct 2014

Tobacco use linked to oral HPV-16

Study participants who reported tobacco use or had higher levels of biomarkers of tobacco exposure had a higher prevalence of the sexually transmitted infection, oral human papillomavirus type 16 (HPV-16), according to a study in the October 8 JAMA, a theme issue on infectious disease.

8 Oct 2014

Novel test could revolutionise discovery of new prescription drugs

A new test developed by researchers from the University of Manchester could revolutionise the discovery of new prescription drugs. The test will help determine which drugs are unlikely to work at an early stage, speeding up the time it takes to make safe and effective medicines available.

From The University of Manchester 3 Oct 2014

3SBio signs exclusive license agreement with JenKem for PEG-irinotecan

3SBio Inc., a leading biotechnology company based in China focusing on researching, developing, manufacturing and marketing biopharmaceutical products, announced today that it has entered into an exclusive license agreement with JenKem Technology Co., Ltd for the development, manufacturing and marketing in Mainland China of PEG-irinotecan, a long-acting polymer-drug conjugate which inhibits topoisomerase I (Topo-I).

17 Sep 2014

ChromaDex signs NIAGEN supply agreement with Healthy Directions

ChromaDex Corp., an innovative natural products company that provides proprietary ingredients and science-based solutions to the dietary supplement, food and beverage, cosmetic and pharmaceutical industries, announced today that it has entered into an ingredient supply agreement with Healthy Directions, a direct-to-consumer nutritional supplement retailer and wholly-owned subsidiary of Helen of Troy Limited.

11 Sep 2014

BIOCRATES launches first-ever bile acids kit based on targeted metabolite quantitation

Austrian BIOCRATES Life Sciences AG, internationally renowned developer and marketer of innovative targeted metabolomics solutions, further expands its range of metabolomics-based kits with the addition of its assay for the determination of endogenous bile acids, allowing a panel of up to 19 analytes to be simultaneously quantitated from a single 10 µL sample of human or mouse plasma.

1 Sep 2014

Postdischarge intervention helps smokers quit smoking

Among hospitalized adult smokers who wanted to quit, a postdischarge intervention that included automated telephone calls and free medication resulted in higher sustained smoking cessation rates at six months than standard postdischarge advice to use smoking cessation medication and counseling, according to a study in the August 20 issue of JAMA.

20 Aug 2014