Metabolites News and Research

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Bile acids: A new therapy against obesity

Obesity arises from an imbalance between energy intake and energy expenditure. As a result, current treatments try to decrease calorie intake and/or increase energy expenditure.

17 Jan 2018

Bile acids could directly burn away lipids in the fat depots

The EPFL scientists discovered that bile acids can turn fat-storing cells into fat-burning ones. This process is called thermogenesis (literally, "heat production") and it helps maintain body temperature in cold environments.

16 Jan 2018

Exposure to estrogen-mimicking compounds may reverse effects of breast cancer treatment

Scientists from The Scripps Research Institute have discovered that two estrogen-mimicking compounds found in many foods appear to potently reverse the effects of palbociclib/letrozole, a popular drug combination for treating breast cancer.

12 Jan 2018

FAU researchers show that fiber-rich diet has positive effect on inflammatory joint diseases

It is well known that healthy eating increases our general sense of wellbeing. Researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg have now discovered that a fiber-rich diet can have a positive influence on chronic inflammatory joint diseases, leading to stronger bones.

12 Jan 2018

International researchers find valuable clues for developing robust therapeutic agents against IBDs

Our immune system protects our bodies from numerous pathogenic microbes and toxins in the environment. The system comprises innate (non-specific) and adaptive (acquired) immunity.

26 Dec 2017

Researchers create visual database of metabolites from blood samples

Researchers in Japan have created a database of metabolites from blood samples collected from over 5,000 Japanese volunteers, making it freely available online as a valuable resource for researchers around the world.

22 Dec 2017

Hormone therapy combination may improve metabolism without increasing risk of reproductive cancer

Treating ovariectomized mice with a combination of conjugated estrogens and the drug bazedoxifene triggers the expression of genes that improve metabolism and prevent weight gain - without stimulating the uterus and increasing risks of reproductive cancer, a new study suggests.

22 Dec 2017

Taurine could boost effectiveness of existing multiple sclerosis therapies

New research suggests that administering taurine, a molecule naturally produced by human cells, could boost the effectiveness of current multiple sclerosis (MS) therapies.

8 Dec 2017

Easy-to-use omics toolkit sets the stage for new era of biology and precision medicine

Most complex diseases, such as obesity, longevity, and diabetes, are largely influenced by genetic factors. But at the same time, they are also modulated by environmental stimuli, such as diet and physical activity.

29 Nov 2017

Metabolites significantly affected in chronic kidney disease, study finds

Chronic kidney disease (CKD) affects 1 in 7 people in the United States, according to the U.S. National Institute of Diabetes & Digestive & Kidney Diseases.

22 Nov 2017

Scientists identify biomarkers that predict risk of death in Ebola patients

Scientists have identified a set of biomarkers that indicate which patients infected with the Ebola virus are most at risk of dying from the disease.

17 Nov 2017

Researchers find low levels of neuroactive steroid in both obese and anorexic women

Women at opposite extremes of the weight spectrum have low levels of the neuroactive steroid allopregnanolone, according to new research published in the journal Neuropsychopharmacology.

10 Nov 2017

Exposure to BPA during pregnancy may lead to long-lasting health problems in offspring

A chemical called bisphenol A -- BPA -- used in plastic packaging and in the linings of food and beverage cans, may be passed from a mother to her offspring during pregnancy and cause changes in the gut bacteria of the offspring, according to an international team of researchers.

8 Nov 2017

Vitamin D supplementation may enhance recovery from burn injuries

Patients with severe burns who have higher levels of vitamin D recover more successfully than those with lower levels, according to a study presented at the Society for Endocrinology annual conference in Harrogate.

6 Nov 2017

GHIT Fund announces US$16.7 million to support development of new drugs, vaccines and diagnostics

The Global Health Innovative Technology Fund, a unique Japanese public-private partnership formed to battle infectious diseases around the globe, today announced US$16.7 million to support development of new compounds for fighting malaria and tuberculosis, a leishmaniasis vaccine and drug, and a treatment for a long-ignored flesh-eating infection.

31 Oct 2017

Researchers uncover surprising immune cell activity that may explain limitations of immunotherapy

Researchers have uncovered a surprising process within a key immune cell that may help explain the limitations of immunotherapy as a cancer treatment.

31 Oct 2017

Researchers investigate how component of soy may suppress breast cancer development

A University of Arizona Cancer Center research team is engaged in a series of studies to investigate how genistein, a component of soy foods, might suppress the development of breast cancer.

31 Oct 2017

Brazilian scientists examine how benzopyrene can cause cancer

Benzo[a]pyrene is a potent carcinogen and mutagen present in cigarette smoke, automotive exhaust, burnt wood fumes, barbecued and smoked meat etc.

23 Oct 2017

Study elucidates how obesity makes breast cancer more aggressive

Obesity leads to the release of cytokines into the bloodstream which impact the metabolism of breast cancer cells, making them more aggressive as a result. Scientists from Helmholtz Zentrum München, Technische Universität München, and Heidelberg University Hospital report on this in 'Cell Metabolism'. The team has already been able to halt this mechanism with an antibody treatment.

23 Oct 2017

Serum metabolites linked to NAFLD may be heritable, research shows

Serum metabolites associated with nonalcoholic fatty liver disease may be heritable, according to research presented this week at The Liver Meeting - held by the American Association for the Study of Liver Diseases.

20 Oct 2017

Metabolites News and Research

Bile acids: A new therapy against obesity

Bile acids could directly burn away lipids in the fat depots

Exposure to estrogen-mimicking compounds may reverse effects of breast cancer treatment

FAU researchers show that fiber-rich diet has positive effect on inflammatory joint diseases

International researchers find valuable clues for developing robust therapeutic agents against IBDs

Researchers create visual database of metabolites from blood samples

Hormone therapy combination may improve metabolism without increasing risk of reproductive cancer

Taurine could boost effectiveness of existing multiple sclerosis therapies

Easy-to-use omics toolkit sets the stage for new era of biology and precision medicine

Metabolites significantly affected in chronic kidney disease, study finds

Scientists identify biomarkers that predict risk of death in Ebola patients

Researchers find low levels of neuroactive steroid in both obese and anorexic women

Exposure to BPA during pregnancy may lead to long-lasting health problems in offspring

Vitamin D supplementation may enhance recovery from burn injuries

GHIT Fund announces US$16.7 million to support development of new drugs, vaccines and diagnostics

Researchers uncover surprising immune cell activity that may explain limitations of immunotherapy

Researchers investigate how component of soy may suppress breast cancer development

Brazilian scientists examine how benzopyrene can cause cancer

Study elucidates how obesity makes breast cancer more aggressive

Serum metabolites linked to NAFLD may be heritable, research shows

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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