Metformin News and Research

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Metformin is the active ingredient in a drug used to treat diabetes mellitus (a condition in which the body cannot control the level of sugar in the blood). It is also being studied in the treatment of cancer. It decreases the amount of glucose (a type of sugar) released into the bloodstream from the liver and increases the body’s use of the glucose. Metformin is a type of antidiabetic agent.

Oral antidiabetics improve outcomes in diabetics with colorectal cancer

Bottom Line: Among patients with both colorectal cancer and diabetes in Korea, those who had a high adherence to their oral diabetes medication had a significantly reduced risk of overall mortality compared with those with lower adherence.

1 Jun 2020

AMPK activation by anti-diabetes drug promotes survival of dormant breast cancer cells

Most breast cancers utilize the female hormone estrogen to grow, so drug-induced estrogen deprivation is used as a treatment in many patients. However, cancer will recur in one-third of these patients.

22 Apr 2020

Newer therapies may benefit patients with type 2 diabetes and coronary artery disease

Type 2 diabetes affects treatment options for patients who have both coronary artery disease and T2D, according to a new American Heart Association Scientific Statement, published today in the Association's flagship journal Circulation.

13 Apr 2020

People with type 2 diabetes and heart disease may benefit from newer therapies

Type 2 diabetes (T2D) may affect treatment options for patients who have both coronary artery disease (CAD) and T2D.

13 Apr 2020

Scientist proposes geroprotective strategies to reduce lethality of COVID-19 in the elderly

The Biogerontology Research Foundation, a registered UK charity supporting and promoting aging and longevity research worldwide since 2008, today announced the publication of a paper titled "Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections" in the leading journal Aging.

6 Apr 2020

Molecule found in oranges could reduce obesity and reverse its negative side-effects

The equivalent of just two and a half glasses of orange juice a day could reverse obesity and reduce the risk of heart disease and diabetes.

3 Mar 2020

Glucose-lowering drug reduces obesity indices in children and adolescents, study shows

A new study has shown metformin - a glucose-lowering drug commonly used to treat diabetes - to be effective at lowering some measures of obesity in children and adolescents.

18 Feb 2020

Acid reflux drug may be a promising therapy to reduce preterm birth

Lansoprazole, an over-the-counter acid reflux drug that is often taken by pregnant women, may be a promising therapy to reduce preterm birth, according to a computational drug repurposing study that also tested several of the drugs in mice.

13 Feb 2020

Metformin could help leaky gut

A team of researchers from University of California, San Diego, have successfully used gut organoids in their lab to show the effects of medications to treat conditions such as “leaky gut”. The study was titled, “The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer,” and was published in the journal Life Science Alliance today.

10 Feb 2020

Statin use alone or with metformin may increase survival in high-risk prostate cancer patients

Among high-risk prostate cancer patients - those with high PSA and Gleason scores of 8 or more - many will develop a difficult-to-treat disease.

10 Feb 2020

Researchers simulate leaky gut conditions using 3D models of human intestines

Once a vague scapegoat for a variety of ills, increasing evidence suggests a condition known as "leaky gut" -- in which microbes and other molecules seep out of the intestines -- may be more common, and more harmful, than previously thought.

10 Feb 2020

Yale researchers find way to reverse type-2 diabetes and liver fibrosis in mice

In a pair of related studies, a team of Yale researchers has found a way to reverse type-2 diabetes and liver fibrosis in mice and has shown that the underlying processes are conserved in humans.

4 Feb 2020

Elevated pre-meal blood sugar levels in pregnant women linked to adverse outcomes

Pregnant women diagnosed with diabetes who have elevated fasting (pre-meal) blood sugar levels are more likely to face complications than those who have only elevated post-meal glucose levels, according to a new study by a University of Alberta research team.

4 Feb 2020

Healing and hope for families affected by fragile X in Eastern Europe

Mothers and fathers and their young children crowded into an old, government-run children's hospital in Belgrade, Serbia, colorful, cartoonish drawings covering its hallway walls. Parents struggled to soothe their anxious, wriggly boys and girls. But they were patient, polite. It was, after all, a day unlike any other. A day for hope.

23 Jan 2020

Houston Methodist scientist proposes new combination treatment for Ewing sarcoma

Ewing sarcoma, an aggressive tumor that commonly affects bones in adolescents and young adults, is diagnosed in about 225 American children and teens every year, accounting for about 1 percent of pediatric cancers.

16 Dec 2019

FDA checks metformin drugs for potentially carcinogenic substance

The FDA is checking metformin medications used to treat diabetes for a potential carcinogen, N-nitrosodimethylamine (NDMA).

11 Dec 2019

Metformin shows benefits on aging and different diseases

Researchers at McMaster University have unlocked one of the secrets behind the many benefits of metformin.

9 Dec 2019

Multiple mechanisms at work in diabetes drug metformin

Metformin is the most commonly prescribed type 2 diabetes drug, yet scientists still do not fully know how it works to control blood sugar levels. In a collaborative effort, researchers from the Salk Institute, The Scripps Research Institute and Weill Cornell Medical College have used a novel technology to investigate why it functions so well.

3 Dec 2019

WHO announces two-year scheme to drive down the price of insulin

The World Health Organization plans to make insulin more affordable for the millions of people suffering from diabetes.

18 Nov 2019

Half the drugs in use damage gut bacteria, says new study

A startling presentation at UEG Week 2019, in Barcelona, reveals that the gut microbiome is at high risk for damage each time we use a drug from one or more of 18 commonly used groups. The effects may range from changes in the relative proportions of different beneficial and potentially harmful species to alterations in the cellular metabolism of the bacteria themselves.

23 Oct 2019

Metformin News and Research

Further Reading

Oral antidiabetics improve outcomes in diabetics with colorectal cancer

AMPK activation by anti-diabetes drug promotes survival of dormant breast cancer cells

Newer therapies may benefit patients with type 2 diabetes and coronary artery disease

People with type 2 diabetes and heart disease may benefit from newer therapies

Scientist proposes geroprotective strategies to reduce lethality of COVID-19 in the elderly

Molecule found in oranges could reduce obesity and reverse its negative side-effects

Glucose-lowering drug reduces obesity indices in children and adolescents, study shows

Acid reflux drug may be a promising therapy to reduce preterm birth

Metformin could help leaky gut

Statin use alone or with metformin may increase survival in high-risk prostate cancer patients

Researchers simulate leaky gut conditions using 3D models of human intestines

Yale researchers find way to reverse type-2 diabetes and liver fibrosis in mice

Elevated pre-meal blood sugar levels in pregnant women linked to adverse outcomes

Healing and hope for families affected by fragile X in Eastern Europe

Houston Methodist scientist proposes new combination treatment for Ewing sarcoma

FDA checks metformin drugs for potentially carcinogenic substance

Metformin shows benefits on aging and different diseases

Multiple mechanisms at work in diabetes drug metformin

WHO announces two-year scheme to drive down the price of insulin

Half the drugs in use damage gut bacteria, says new study

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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