Metformin News and Research

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Metformin is the active ingredient in a drug used to treat diabetes mellitus (a condition in which the body cannot control the level of sugar in the blood). It is also being studied in the treatment of cancer. It decreases the amount of glucose (a type of sugar) released into the bloodstream from the liver and increases the body’s use of the glucose. Metformin is a type of antidiabetic agent.

Metformin potently inhibits SARS-CoV-2-induced cytokine release in monocytes

An interesting new bioRxiv* preprint reports the suppression of monocyte glycolysis and cytokine production when exposed to the virus, following pretreatment with the commonly used drug, metformin.

6 Jun 2021

Asthma patients can benefit from type 2 diabetes medication

Type 2 diabetes patients who also have asthma are benefitting from a diabetes medication, typically given to help the pancreas produce more insulin, that also improves asthma symptoms and may reduce lung and airway inflammation.

21 May 2021

GeroSense AI tracks biological age and resilience via smartphone sensor data

Gero has developed and validated GeroSense AI to track biological age and resilience via smartphone sensor data. The performance of the new health and aging markers have been recently reported in a paper in Aging US.

11 May 2021

Study examines risk phenotypes of diabetes and their association with COVID-19 severity

People with diabetes are at increased risk of developing a severe course of COVID-19 compared to people without diabetes.

29 Apr 2021

Anti-diabetic drug metformin inhibits disease progression in Alport syndrome mouse model

Researchers from Kumamoto University have found that the anti-diabetic drug metformin significantly prolongs the survival of mice in a model that simulates the pathology of non-diabetic chronic kidney disease (ND-CKD) by ameliorating pathological conditions like reduced kidney function, glomerular damage, inflammation and fibrosis.

15 Apr 2021

Anti-diabetic drug phenformin may prompt stronger cancer-fighting activities

The anti-diabetic drug phenformin may prompt stronger cancer-fighting activities than its sister compound metformin, a finding that could have major implications for current and future clinical trials investigating both agents for their anti-cancer potential, according to researchers at Massachusetts General Hospital (MGH).

15 Apr 2021

Parkinson's disease, type 2 diabetes, and cancer share the same pathway, shows study

When cells are stressed, chemical alarms go off, setting in motion a flurry of activity that protects the cell's most important players. During the rush, a protein called Parkin hurries to protect the mitochondria, the power stations that generate energy for the cell.

8 Apr 2021

Hopkins Medicine endocrinologist publishes first clinical practice review on diabetes management

New medicines for people who have diabetes seem to pop up all the time. Drugs that help the body break down carbohydrates, drugs that increase excretion of glucose in the urine, drugs that help muscles respond to insulin and drugs that stimulate the pancreas to produce it -; the list of pharmaceutical options to treat diabetes gets longer and longer.

7 Apr 2021

Diabetes drug appears to exploit vulnerability of AIDS-causing retrovirus HIV

A team led by scientists at the UNC School of Medicine discovered an important vulnerability of the AIDS-causing retrovirus HIV, and has shown in preclinical experiments that a widely used diabetes drug, metformin, seems able to exploit this vulnerability.

29 Mar 2021

Type 2 diabetes drug can successfully reduce symptoms associated with tuberous sclerosis complex

A team of researchers led by UCL Great Ormond Street Institute of Child Health and Great Ormond Street Hospital (GOSH) has found that metformin - a drug commonly used to treat Type 2 diabetes - can successfully reduce symptoms associated with tuberous sclerosis complex (TSC), including reduction in the frequency of seizures and the size of brain tumors.

29 Mar 2021

Researchers explore a case of diabetic ketoacidosis in patient with atezolizumab-induced autoimmune diabetes

In a new publication from Cardiovascular Innovations and Applications, Sharen Lee and Gary Tse from Laboratory of Cardiovascular Physiology, Hong Kong, HKG, China, Second Hospital of Tianjin Medical University, Tianjin, China and Xiamen Cardiovascular Hospital, Xiamen, China consider a case of atezolizumab-induced autoimmune diabetes mellitus presenting with diabetic ketoacidosis.

29 Mar 2021

Scientists seek Covid treatment answers in cheap, older drugs

Could a decades-old antidepressant be a secret weapon against covid? A few scientists think so, after two small studies showed that fluvoxamine, typically prescribed for obsessive-compulsive disorder, prevented serious illness in all participants who took the pills soon after developing symptoms.

29 Mar 2021

Antidiabetic drug could help reduce chronic inflammation in people living with HIV

Metformin, a drug used to treat type-2 diabetes, could help reduce chronic inflammation in people living with HIV (PLWH) who are being treated with antiretroviral therapy (ART), according to researchers at the University of Montreal Hospital Research Centre.

18 Mar 2021

Study: Semaglutide drug promotes weight loss in patients with type 2 diabetes

Patients with type 2 diabetes that were treated with a weekly injection of the breakthrough drug Semaglutide were able to achieve an average weight loss of nearly 10kg, according to a new study published in The Lancet today.

3 Mar 2021

Study: Body produces large amounts of GDF15 hormone during extended bouts of vigorous exercise

A drug that helps us to eat less could help the more than 650 million people around the world who live with obesity.

17 Feb 2021

New study to evaluate the effectiveness of drugs on preventing COVID-19 progression

McMaster University researchers are leading a large international study to test drugs to treat COVID-19 patients.

9 Feb 2021

Oncotarget publishes new research on geroscience

Dr. Mikhail V. Blagosklonny, M.D., Ph.D., Editor-in-Chief of Oncotarget, and Professor, at Roswell Park Cancer Institute, published "The goal of geroscience is life extension" which was selected as the Featured Cover Paper for Volume 12 Issue 3 and reported that although numerous drugs seemingly extend healthspan in mice, only a few extend lifespan in mice and only one does it consistently.

4 Feb 2021

Metformin News and Research

Further Reading

Metformin potently inhibits SARS-CoV-2-induced cytokine release in monocytes

Asthma patients can benefit from type 2 diabetes medication

GeroSense AI tracks biological age and resilience via smartphone sensor data

Study examines risk phenotypes of diabetes and their association with COVID-19 severity

Anti-diabetic drug metformin inhibits disease progression in Alport syndrome mouse model

Anti-diabetic drug phenformin may prompt stronger cancer-fighting activities

Parkinson's disease, type 2 diabetes, and cancer share the same pathway, shows study

Hopkins Medicine endocrinologist publishes first clinical practice review on diabetes management

Diabetes drug appears to exploit vulnerability of AIDS-causing retrovirus HIV

Type 2 diabetes drug can successfully reduce symptoms associated with tuberous sclerosis complex

Researchers explore a case of diabetic ketoacidosis in patient with atezolizumab-induced autoimmune diabetes

Scientists seek Covid treatment answers in cheap, older drugs

Antidiabetic drug could help reduce chronic inflammation in people living with HIV

Study: Semaglutide drug promotes weight loss in patients with type 2 diabetes

Study: Body produces large amounts of GDF15 hormone during extended bouts of vigorous exercise

New study to evaluate the effectiveness of drugs on preventing COVID-19 progression

Oncotarget publishes new research on geroscience

Can metformin reduce mortality in diabetic individuals with severe COVID-19?

New automated measurement system to assess healthy lifespans using nematodes

New compound could lead to a new class of diabetes drugs

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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